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Article: Confirmation of linkage to chromosome 1q for spine bone mineral density in southern Chinese

TitleConfirmation of linkage to chromosome 1q for spine bone mineral density in southern Chinese
Authors
KeywordsBMD
Genetics
Linkage
Osteoporosis
Issue Date2006
PublisherSpringer Verlag. The Journal's web site is located at http://link.springer.de/link/service/journals/00439/index.htm
Citation
Human Genetics, 2006, v. 120 n. 3, p. 354-359 How to Cite?
AbstractChromosome 1q has previously been linked to bone mineral density (BMD) variation in the general population in several genome-wide linkage studies in both humans and mouse model. The aim of present study is to replicate and fine map the QTL influencing BMD in chromosome 1q in southern Chinese. Twelve microsatellite markers were genotyped for a 57cM region in the chromosome 1q in 306 southern Chinese families with 1,459 subjects. Each of these families was ascertained through a proband with BMD Z-scores less than - 1.3 at the hip or spine. BMD (g/cm 2) at the L1-4 lumbar spine, femoral neck (FN), trochanter and total hip was measured by dual-energy X-ray absortiometry. Linkage analyses were performed using the variance component linkage analysis method implemented in Merlin software. Four markers (D1S2878, D1S196, D1S452, and D1S218) achieved a LOD score greater than 1.0 with spine BMD, with the maximum multipoint LOD score of 2.36 at the marker D1S196. We did not detect a LOD score greater than 1.0 for BMD at the FN, trochanter, or total hip in multipoint linkage analyses. Our results present the first evidence for the presence of an osteoporosis susceptibility gene on chromosome 1q in non-Caucasian subjects. Further analyses of candidate genes are warranted to identify QTL genes and variants underlying the variations of BMD in this region. © Springer-Verlag 2006.
Persistent Identifierhttp://hdl.handle.net/10722/76656
ISSN
2015 Impact Factor: 5.138
2015 SCImago Journal Rankings: 2.931
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorCheung, CLen_HK
dc.contributor.authorHuang, QYen_HK
dc.contributor.authorNg, MYMen_HK
dc.contributor.authorChan, Ven_HK
dc.contributor.authorSham, PCen_HK
dc.contributor.authorKung, AWCen_HK
dc.date.accessioned2010-09-06T07:23:32Z-
dc.date.available2010-09-06T07:23:32Z-
dc.date.issued2006en_HK
dc.identifier.citationHuman Genetics, 2006, v. 120 n. 3, p. 354-359en_HK
dc.identifier.issn0340-6717en_HK
dc.identifier.urihttp://hdl.handle.net/10722/76656-
dc.description.abstractChromosome 1q has previously been linked to bone mineral density (BMD) variation in the general population in several genome-wide linkage studies in both humans and mouse model. The aim of present study is to replicate and fine map the QTL influencing BMD in chromosome 1q in southern Chinese. Twelve microsatellite markers were genotyped for a 57cM region in the chromosome 1q in 306 southern Chinese families with 1,459 subjects. Each of these families was ascertained through a proband with BMD Z-scores less than - 1.3 at the hip or spine. BMD (g/cm 2) at the L1-4 lumbar spine, femoral neck (FN), trochanter and total hip was measured by dual-energy X-ray absortiometry. Linkage analyses were performed using the variance component linkage analysis method implemented in Merlin software. Four markers (D1S2878, D1S196, D1S452, and D1S218) achieved a LOD score greater than 1.0 with spine BMD, with the maximum multipoint LOD score of 2.36 at the marker D1S196. We did not detect a LOD score greater than 1.0 for BMD at the FN, trochanter, or total hip in multipoint linkage analyses. Our results present the first evidence for the presence of an osteoporosis susceptibility gene on chromosome 1q in non-Caucasian subjects. Further analyses of candidate genes are warranted to identify QTL genes and variants underlying the variations of BMD in this region. © Springer-Verlag 2006.en_HK
dc.languageengen_HK
dc.publisherSpringer Verlag. The Journal's web site is located at http://link.springer.de/link/service/journals/00439/index.htmen_HK
dc.relation.ispartofHuman Geneticsen_HK
dc.subjectBMDen_HK
dc.subjectGeneticsen_HK
dc.subjectLinkageen_HK
dc.subjectOsteoporosisen_HK
dc.subject.meshAdult-
dc.subject.meshAged-
dc.subject.meshBone Density-
dc.subject.meshChina-
dc.subject.meshChromosomes, Human, Pair 1-
dc.subject.meshFemale-
dc.subject.meshHumans-
dc.subject.meshLod Score-
dc.subject.meshLumbosacral Region - Anatomy & Histology-
dc.subject.meshMale-
dc.subject.meshMiddle Aged-
dc.subject.meshSpine - Anatomy & Histology - Physiology-
dc.titleConfirmation of linkage to chromosome 1q for spine bone mineral density in southern Chineseen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0340-6717&volume=120&spage=354&epage=359&date=2006&atitle=Confirmation+of+linkage+to+chromosome+1q+for+spine+bone+mineral+density+in+southern+Chineseen_HK
dc.identifier.emailCheung, CL: lung1212@hku.hken_HK
dc.identifier.emailHuang, QY: qyhuang@hotmail.comen_HK
dc.identifier.emailChan, V: vnychana@hkucc.hku.hken_HK
dc.identifier.emailSham, PC: pcsham@hku.hken_HK
dc.identifier.emailKung, AWC: awckung@hku.hken_HK
dc.identifier.authorityCheung, CL=rp01749en_HK
dc.identifier.authorityHuang, QY=rp00521en_HK
dc.identifier.authorityChan, V=rp00320en_HK
dc.identifier.authoritySham, PC=rp00459en_HK
dc.identifier.authorityKung, AWC=rp00368en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1007/s00439-006-0220-3en_HK
dc.identifier.pmid16847694-
dc.identifier.scopuseid_2-s2.0-33748742621en_HK
dc.identifier.hkuros121339en_HK
dc.identifier.hkuros136315-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-33748742621&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume120en_HK
dc.identifier.issue3en_HK
dc.identifier.spage354en_HK
dc.identifier.epage359en_HK
dc.identifier.isiWOS:000240613900003-
dc.publisher.placeGermanyen_HK
dc.identifier.scopusauthoridCheung, CL=14520953400en_HK
dc.identifier.scopusauthoridHuang, QY=7403630787en_HK
dc.identifier.scopusauthoridNg, MYM=8367886400en_HK
dc.identifier.scopusauthoridChan, V=7202654865en_HK
dc.identifier.scopusauthoridSham, PC=34573429300en_HK
dc.identifier.scopusauthoridKung, AWC=7102322339en_HK
dc.identifier.citeulike964488-

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