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Article: The study of chinese medicinal herbal formula shen san fang in the treatment of experimental iga nephropathy

TitleThe study of chinese medicinal herbal formula shen san fang in the treatment of experimental iga nephropathy
Authors
KeywordsAnimal model
Astragalus membranaceus
IgA nephropathy
Lycium barbarum
Rehmannia glutinosa
Traditional chinese medicine
Transforming growth factor-β1
Issue Date2005
PublisherWorld Scientific Publishing Co Pte Ltd. The Journal's web site is located at http://www.worldscinet.com/ajcm/ajcm.shtml
Citation
American Journal Of Chinese Medicine, 2005, v. 33 n. 4, p. 613-626 How to Cite?
AbstractIgA nephropathy (IgAN) is the most common primary glomerulonephritis worldwide, yet there is no effective or specific therapy. Shen San Fang (S3F) is a traditional Chinese herbal medicinal formula that has been used in China for many years to treat patients with hematuria. The aim of this study is to test the therapeutic value of S3F in an experimental model of IgAN. IgAN was induced in Lewis rats by continuous oral immunization with bovine gamma-globulin (BGG) in the drinking water for 8 weeks, followed by intravenous injection of 1 mg BGG daily for 3 successive days. The rats were randomly divided into four groups (five rats/group): control, control receiving S3F, induction of IgAN, and IgAN receiving S3F. S3F decoction was fed to rats beginning week 4 from the first day of oral sensitization with BGG. The S3F treatment was continued until the rats were sacrificed or for a 4-week period. Hematuria, renal immunohistochemistry for IgA and transforming growth factor-beta 1 (TGF-β1), renal histopathology, and renal content of TGF-β1 were measured. Rats developing IgAN had marked hematuria, profound mesangial proliferation and mesangial expansion, intense and diffuse glomerular IgA deposition, increased glomerular TGF-β1 expression, and raised renal TGF-β1 levels. S3F treatment resulted in a significant reduction of hematuria, decreased mesangial IgA deposition, weaker immunostaining of TGF-β1 in glomerulus, and a lower renal TGF-β1 concentration. Our animal data suggests a therapeutic value for the Chinese medicinal formula S3F in experimental IgAN. This beneficial effect was due to reduced glomerular IgA deposition and TGF-β1 expression. Our preliminary findings hold promise for future human therapy. © 2005 World Scientific Publishing Company Institute for Advanced Research in Asian Science and Medicine.
Persistent Identifierhttp://hdl.handle.net/10722/76631
ISSN
2015 Impact Factor: 2.959
2015 SCImago Journal Rankings: 0.797
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorZhong, Qen_HK
dc.contributor.authorLeung, JCKen_HK
dc.contributor.authorChan, LYYen_HK
dc.contributor.authorTsang, AWLen_HK
dc.contributor.authorChen, Xen_HK
dc.contributor.authorLai, KNen_HK
dc.date.accessioned2010-09-06T07:23:17Z-
dc.date.available2010-09-06T07:23:17Z-
dc.date.issued2005en_HK
dc.identifier.citationAmerican Journal Of Chinese Medicine, 2005, v. 33 n. 4, p. 613-626en_HK
dc.identifier.issn0192-415Xen_HK
dc.identifier.urihttp://hdl.handle.net/10722/76631-
dc.description.abstractIgA nephropathy (IgAN) is the most common primary glomerulonephritis worldwide, yet there is no effective or specific therapy. Shen San Fang (S3F) is a traditional Chinese herbal medicinal formula that has been used in China for many years to treat patients with hematuria. The aim of this study is to test the therapeutic value of S3F in an experimental model of IgAN. IgAN was induced in Lewis rats by continuous oral immunization with bovine gamma-globulin (BGG) in the drinking water for 8 weeks, followed by intravenous injection of 1 mg BGG daily for 3 successive days. The rats were randomly divided into four groups (five rats/group): control, control receiving S3F, induction of IgAN, and IgAN receiving S3F. S3F decoction was fed to rats beginning week 4 from the first day of oral sensitization with BGG. The S3F treatment was continued until the rats were sacrificed or for a 4-week period. Hematuria, renal immunohistochemistry for IgA and transforming growth factor-beta 1 (TGF-β1), renal histopathology, and renal content of TGF-β1 were measured. Rats developing IgAN had marked hematuria, profound mesangial proliferation and mesangial expansion, intense and diffuse glomerular IgA deposition, increased glomerular TGF-β1 expression, and raised renal TGF-β1 levels. S3F treatment resulted in a significant reduction of hematuria, decreased mesangial IgA deposition, weaker immunostaining of TGF-β1 in glomerulus, and a lower renal TGF-β1 concentration. Our animal data suggests a therapeutic value for the Chinese medicinal formula S3F in experimental IgAN. This beneficial effect was due to reduced glomerular IgA deposition and TGF-β1 expression. Our preliminary findings hold promise for future human therapy. © 2005 World Scientific Publishing Company Institute for Advanced Research in Asian Science and Medicine.en_HK
dc.languageengen_HK
dc.publisherWorld Scientific Publishing Co Pte Ltd. The Journal's web site is located at http://www.worldscinet.com/ajcm/ajcm.shtmlen_HK
dc.relation.ispartofAmerican Journal of Chinese Medicineen_HK
dc.subjectAnimal modelen_HK
dc.subjectAstragalus membranaceusen_HK
dc.subjectIgA nephropathyen_HK
dc.subjectLycium barbarumen_HK
dc.subjectRehmannia glutinosaen_HK
dc.subjectTraditional chinese medicineen_HK
dc.subjectTransforming growth factor-β1en_HK
dc.subject.meshAnimalsen_HK
dc.subject.meshDisease Models, Animalen_HK
dc.subject.meshDrugs, Chinese Herbal - pharmacologyen_HK
dc.subject.meshGlomerulonephritis, IGA - drug therapy - immunology - pathologyen_HK
dc.subject.meshHematuria - drug therapyen_HK
dc.subject.meshImmunizationen_HK
dc.subject.meshImmunohistochemistryen_HK
dc.subject.meshKidney Glomerulus - immunology - metabolism - pathologyen_HK
dc.subject.meshMaleen_HK
dc.subject.meshRatsen_HK
dc.subject.meshRats, Inbred Lewen_HK
dc.subject.meshTransforming Growth Factor beta - metabolismen_HK
dc.subject.meshTransforming Growth Factor beta1en_HK
dc.subject.meshUrinalysisen_HK
dc.subject.meshgamma-Globulins - immunologyen_HK
dc.titleThe study of chinese medicinal herbal formula shen san fang in the treatment of experimental iga nephropathyen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0192-415X&volume=33&issue=4&spage=613&epage=626&date=2005&atitle=The+study+of+Chinese+medicinal+herbal+formula+Shen+San+Fang+in+the+treatment+of+experimental+IgA+nephropathyen_HK
dc.identifier.emailLeung, JCK: jckleung@hku.hken_HK
dc.identifier.emailLai, KN: knlai@hku.hken_HK
dc.identifier.authorityLeung, JCK=rp00448en_HK
dc.identifier.authorityLai, KN=rp00324en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1142/S0192415X05003211en_HK
dc.identifier.pmid16173535-
dc.identifier.scopuseid_2-s2.0-23944467161en_HK
dc.identifier.hkuros121464en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-23944467161&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume33en_HK
dc.identifier.issue4en_HK
dc.identifier.spage613en_HK
dc.identifier.epage626en_HK
dc.identifier.isiWOS:000231929800010-
dc.publisher.placeSingaporeen_HK
dc.identifier.scopusauthoridZhong, Q=36830894500en_HK
dc.identifier.scopusauthoridLeung, JCK=7202180349en_HK
dc.identifier.scopusauthoridChan, LYY=8108378300en_HK
dc.identifier.scopusauthoridTsang, AWL=7006979244en_HK
dc.identifier.scopusauthoridChen, X=8542189800en_HK
dc.identifier.scopusauthoridLai, KN=7402135706en_HK

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