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Article: Effects of temporal application parameters on lesion dimensions during transvenous catheter cryoablation

TitleEffects of temporal application parameters on lesion dimensions during transvenous catheter cryoablation
Authors
KeywordsAblation
Cryoablation
Lesion dimension
Issue Date2005
PublisherWiley-Blackwell Publishing, Inc.. The Journal's web site is located at http://www.wiley.com/bw/journal.asp?ref=1045-3873
Citation
Journal Of Cardiovascular Electrophysiology, 2005, v. 16 n. 2, p. 201-204 How to Cite?
AbstractBackground: Transvenous catheter cryoablation is a novel technique for treating cardiac arrhythmias. However, the relative importance of temporal application parameters on lesion dimension and clinical efficacy has not been studied. Methods and Results: We investigated the effects of (1) application duration: single 2.5 (2.5 x 1) versus single 5 versus double 2.5 (2.5 x 2) versus double 5 (5 x 2) minutes, (2) number of freeze-thaw cycles: single versus double, and (3) electrode contact area: horizontal versus vertical orientation, on the lesion diameter and depth during catheter cryoablation (10F, 6.5-mm tip-electrode, CryoCorâ„¢, San Diego) in a thigh muscle preparation. A total of 175 lesions (horizontal = 90, vertical = 85) were created in thigh muscle preparations on 10 swine. The lesion diameter and depth were significantly greater using 2.5 x 2 and 5 x 2 application modes as compared with 2.5 x 1 applications (P < 0.05). Horizontal tip-electrode orientation produced larger lesion diameter (P < 0.05), but not lesion depth as compared with vertical orientation. Multivariate analysis demonstrated that both tip-electrode orientation and duration of freeze >2.5 minutes were independent predictors for lesion diameter (P < 0.001). However, only duration of freeze >2.5 minutes was an independent predictor for lesion depth (P < 0.001). Conclusions: The dimensions of lesions created by catheter cryoablation are affected by mode of cryoablation application and electrode orientation. Increasing the duration of application, employing multiple freeze-thaw cycles at shorter cycle durations, and orienting the catheter to enhance/increase tissue contact can create a larger lesion.
Persistent Identifierhttp://hdl.handle.net/10722/76620
ISSN
2023 Impact Factor: 2.3
2023 SCImago Journal Rankings: 1.144
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorTse, HFen_HK
dc.contributor.authorRipley, KLen_HK
dc.contributor.authorLee, KLFen_HK
dc.contributor.authorSiu, CWen_HK
dc.contributor.authorVan Vleet, JFen_HK
dc.contributor.authorPelkey, WLen_HK
dc.contributor.authorLau, CPen_HK
dc.date.accessioned2010-09-06T07:23:10Z-
dc.date.available2010-09-06T07:23:10Z-
dc.date.issued2005en_HK
dc.identifier.citationJournal Of Cardiovascular Electrophysiology, 2005, v. 16 n. 2, p. 201-204en_HK
dc.identifier.issn1045-3873en_HK
dc.identifier.urihttp://hdl.handle.net/10722/76620-
dc.description.abstractBackground: Transvenous catheter cryoablation is a novel technique for treating cardiac arrhythmias. However, the relative importance of temporal application parameters on lesion dimension and clinical efficacy has not been studied. Methods and Results: We investigated the effects of (1) application duration: single 2.5 (2.5 x 1) versus single 5 versus double 2.5 (2.5 x 2) versus double 5 (5 x 2) minutes, (2) number of freeze-thaw cycles: single versus double, and (3) electrode contact area: horizontal versus vertical orientation, on the lesion diameter and depth during catheter cryoablation (10F, 6.5-mm tip-electrode, CryoCorâ„¢, San Diego) in a thigh muscle preparation. A total of 175 lesions (horizontal = 90, vertical = 85) were created in thigh muscle preparations on 10 swine. The lesion diameter and depth were significantly greater using 2.5 x 2 and 5 x 2 application modes as compared with 2.5 x 1 applications (P < 0.05). Horizontal tip-electrode orientation produced larger lesion diameter (P < 0.05), but not lesion depth as compared with vertical orientation. Multivariate analysis demonstrated that both tip-electrode orientation and duration of freeze >2.5 minutes were independent predictors for lesion diameter (P < 0.001). However, only duration of freeze >2.5 minutes was an independent predictor for lesion depth (P < 0.001). Conclusions: The dimensions of lesions created by catheter cryoablation are affected by mode of cryoablation application and electrode orientation. Increasing the duration of application, employing multiple freeze-thaw cycles at shorter cycle durations, and orienting the catheter to enhance/increase tissue contact can create a larger lesion.en_HK
dc.languageengen_HK
dc.publisherWiley-Blackwell Publishing, Inc.. The Journal's web site is located at http://www.wiley.com/bw/journal.asp?ref=1045-3873en_HK
dc.relation.ispartofJournal of Cardiovascular Electrophysiologyen_HK
dc.subjectAblation-
dc.subjectCryoablation-
dc.subjectLesion dimension-
dc.subject.meshAnimalsen_HK
dc.subject.meshCatheter Ablation - methodsen_HK
dc.subject.meshCryosurgery - methodsen_HK
dc.subject.meshElectrodesen_HK
dc.subject.meshMultivariate Analysisen_HK
dc.subject.meshMuscles - pathologyen_HK
dc.subject.meshSwineen_HK
dc.subject.meshTime Factorsen_HK
dc.titleEffects of temporal application parameters on lesion dimensions during transvenous catheter cryoablationen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1045-3873&volume=16&issue=2&spage=201&epage=4&date=2005&atitle=Effects+of+temporal+application+parameters+on+lesion+dimensions+during+transvenous+catheter+cryoablationen_HK
dc.identifier.emailTse, HF:hftse@hkucc.hku.hken_HK
dc.identifier.emailSiu, CW:cwdsiu@hkucc.hku.hken_HK
dc.identifier.authorityTse, HF=rp00428en_HK
dc.identifier.authoritySiu, CW=rp00534en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1046/j.1540-8167.2005.40559.xen_HK
dc.identifier.pmid15720460-
dc.identifier.scopuseid_2-s2.0-14644438524en_HK
dc.identifier.hkuros113809en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-14644438524&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume16en_HK
dc.identifier.issue2en_HK
dc.identifier.spage201en_HK
dc.identifier.epage204en_HK
dc.identifier.isiWOS:000226963800016-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridTse, HF=7006070805en_HK
dc.identifier.scopusauthoridRipley, KL=6701380533en_HK
dc.identifier.scopusauthoridLee, KLF=7501505962en_HK
dc.identifier.scopusauthoridSiu, CW=7006550690en_HK
dc.identifier.scopusauthoridVan Vleet, JF=7005542715en_HK
dc.identifier.scopusauthoridPelkey, WL=8253704600en_HK
dc.identifier.scopusauthoridLau, CP=7401968501en_HK
dc.identifier.citeulike94028-
dc.identifier.issnl1045-3873-

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