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Article: Effects of temporal application parameters on lesion dimensions during transvenous catheter cryoablation

TitleEffects of temporal application parameters on lesion dimensions during transvenous catheter cryoablation
Authors
Issue Date2005
PublisherWiley-Blackwell Publishing, Inc.. The Journal's web site is located at http://www.wiley.com/bw/journal.asp?ref=1045-3873
Citation
Journal Of Cardiovascular Electrophysiology, 2005, v. 16 n. 2, p. 201-204 How to Cite?
AbstractBackground: Transvenous catheter cryoablation is a novel technique for treating cardiac arrhythmias. However, the relative importance of temporal application parameters on lesion dimension and clinical efficacy has not been studied. Methods and Results: We investigated the effects of (1) application duration: single 2.5 (2.5 x 1) versus single 5 versus double 2.5 (2.5 x 2) versus double 5 (5 x 2) minutes, (2) number of freeze-thaw cycles: single versus double, and (3) electrode contact area: horizontal versus vertical orientation, on the lesion diameter and depth during catheter cryoablation (10F, 6.5-mm tip-electrode, CryoCorâ„¢, San Diego) in a thigh muscle preparation. A total of 175 lesions (horizontal = 90, vertical = 85) were created in thigh muscle preparations on 10 swine. The lesion diameter and depth were significantly greater using 2.5 x 2 and 5 x 2 application modes as compared with 2.5 x 1 applications (P < 0.05). Horizontal tip-electrode orientation produced larger lesion diameter (P < 0.05), but not lesion depth as compared with vertical orientation. Multivariate analysis demonstrated that both tip-electrode orientation and duration of freeze >2.5 minutes were independent predictors for lesion diameter (P < 0.001). However, only duration of freeze >2.5 minutes was an independent predictor for lesion depth (P < 0.001). Conclusions: The dimensions of lesions created by catheter cryoablation are affected by mode of cryoablation application and electrode orientation. Increasing the duration of application, employing multiple freeze-thaw cycles at shorter cycle durations, and orienting the catheter to enhance/increase tissue contact can create a larger lesion.
Persistent Identifierhttp://hdl.handle.net/10722/76620
ISSN
2015 Impact Factor: 3.097
2015 SCImago Journal Rankings: 1.863
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorTse, HFen_HK
dc.contributor.authorRipley, KLen_HK
dc.contributor.authorLee, KLFen_HK
dc.contributor.authorSiu, CWen_HK
dc.contributor.authorVan Vleet, JFen_HK
dc.contributor.authorPelkey, WLen_HK
dc.contributor.authorLau, CPen_HK
dc.date.accessioned2010-09-06T07:23:10Z-
dc.date.available2010-09-06T07:23:10Z-
dc.date.issued2005en_HK
dc.identifier.citationJournal Of Cardiovascular Electrophysiology, 2005, v. 16 n. 2, p. 201-204en_HK
dc.identifier.issn1045-3873en_HK
dc.identifier.urihttp://hdl.handle.net/10722/76620-
dc.description.abstractBackground: Transvenous catheter cryoablation is a novel technique for treating cardiac arrhythmias. However, the relative importance of temporal application parameters on lesion dimension and clinical efficacy has not been studied. Methods and Results: We investigated the effects of (1) application duration: single 2.5 (2.5 x 1) versus single 5 versus double 2.5 (2.5 x 2) versus double 5 (5 x 2) minutes, (2) number of freeze-thaw cycles: single versus double, and (3) electrode contact area: horizontal versus vertical orientation, on the lesion diameter and depth during catheter cryoablation (10F, 6.5-mm tip-electrode, CryoCorâ„¢, San Diego) in a thigh muscle preparation. A total of 175 lesions (horizontal = 90, vertical = 85) were created in thigh muscle preparations on 10 swine. The lesion diameter and depth were significantly greater using 2.5 x 2 and 5 x 2 application modes as compared with 2.5 x 1 applications (P < 0.05). Horizontal tip-electrode orientation produced larger lesion diameter (P < 0.05), but not lesion depth as compared with vertical orientation. Multivariate analysis demonstrated that both tip-electrode orientation and duration of freeze >2.5 minutes were independent predictors for lesion diameter (P < 0.001). However, only duration of freeze >2.5 minutes was an independent predictor for lesion depth (P < 0.001). Conclusions: The dimensions of lesions created by catheter cryoablation are affected by mode of cryoablation application and electrode orientation. Increasing the duration of application, employing multiple freeze-thaw cycles at shorter cycle durations, and orienting the catheter to enhance/increase tissue contact can create a larger lesion.en_HK
dc.languageengen_HK
dc.publisherWiley-Blackwell Publishing, Inc.. The Journal's web site is located at http://www.wiley.com/bw/journal.asp?ref=1045-3873en_HK
dc.relation.ispartofJournal of Cardiovascular Electrophysiologyen_HK
dc.subject.meshAnimalsen_HK
dc.subject.meshCatheter Ablation - methodsen_HK
dc.subject.meshCryosurgery - methodsen_HK
dc.subject.meshElectrodesen_HK
dc.subject.meshMultivariate Analysisen_HK
dc.subject.meshMuscles - pathologyen_HK
dc.subject.meshSwineen_HK
dc.subject.meshTime Factorsen_HK
dc.titleEffects of temporal application parameters on lesion dimensions during transvenous catheter cryoablationen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1045-3873&volume=16&issue=2&spage=201&epage=4&date=2005&atitle=Effects+of+temporal+application+parameters+on+lesion+dimensions+during+transvenous+catheter+cryoablationen_HK
dc.identifier.emailTse, HF:hftse@hkucc.hku.hken_HK
dc.identifier.emailSiu, CW:cwdsiu@hkucc.hku.hken_HK
dc.identifier.authorityTse, HF=rp00428en_HK
dc.identifier.authoritySiu, CW=rp00534en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1046/j.1540-8167.2005.40559.xen_HK
dc.identifier.pmid15720460-
dc.identifier.scopuseid_2-s2.0-14644438524en_HK
dc.identifier.hkuros113809en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-14644438524&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume16en_HK
dc.identifier.issue2en_HK
dc.identifier.spage201en_HK
dc.identifier.epage204en_HK
dc.identifier.isiWOS:000226963800016-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridTse, HF=7006070805en_HK
dc.identifier.scopusauthoridRipley, KL=6701380533en_HK
dc.identifier.scopusauthoridLee, KLF=7501505962en_HK
dc.identifier.scopusauthoridSiu, CW=7006550690en_HK
dc.identifier.scopusauthoridVan Vleet, JF=7005542715en_HK
dc.identifier.scopusauthoridPelkey, WL=8253704600en_HK
dc.identifier.scopusauthoridLau, CP=7401968501en_HK
dc.identifier.citeulike94028-

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