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Article: Dimethyl sulfoxide as an inducer of differentiation in preosteoblast MC3T3-E1 cells

TitleDimethyl sulfoxide as an inducer of differentiation in preosteoblast MC3T3-E1 cells
Authors
Cheung, WMWNg, WWKung, AWC
KeywordsDMSO
Erk
Osteoblasts
PKD
Proliferation
Protein kinase C
Issue Date2006
PublisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/febslet
Citation
Febs Letters, 2006, v. 580 n. 1, p. 121-126 How to Cite?
DOI: http://dx.doi.org/10.1016/j.febslet.2005.11.062
AbstractOsteoblastic differentiation is an essential part of bone formation. Dimethyl sulfoxide (DMSO) is a water miscible solvent that is used extensively for receptor ligands in osteoblast studies. However, little is known about its effects on osteoblastogenic precursor cells. In this study, we have used a murine preosteoblast cell line MC3T3-E1 cells to demonstrate that DMSO effectively induces osteoblastic differentiation of MC3T3-E1 cells via the activation of Runx2 and osterix and is dependent upon the protein kinase C (PKC) pathways. We further demonstrated that prolonged activation of PKC pathways is sufficient to induce osteoblastic differentiation, possibly via the activation of PKD/PKCμ. © 2005 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/76606
ISSN
0014-5793
2023 Impact Factor: 3.0
2023 SCImago Journal Rankings: 1.208
ISI Accession Number ID
WOS:000234605100022
References
References in Scopus

 

DC FieldValueLanguage
dc.contributor.authorCheung, WMWen_HK
dc.contributor.authorNg, WWen_HK
dc.contributor.authorKung, AWCen_HK
dc.date.accessioned2010-09-06T07:23:01Z-
dc.date.available2010-09-06T07:23:01Z-
dc.date.issued2006en_HK
dc.identifier.citationFebs Letters, 2006, v. 580 n. 1, p. 121-126en_HK
dc.identifier.issn0014-5793en_HK
dc.identifier.urihttp://hdl.handle.net/10722/76606-
dc.description.abstractOsteoblastic differentiation is an essential part of bone formation. Dimethyl sulfoxide (DMSO) is a water miscible solvent that is used extensively for receptor ligands in osteoblast studies. However, little is known about its effects on osteoblastogenic precursor cells. In this study, we have used a murine preosteoblast cell line MC3T3-E1 cells to demonstrate that DMSO effectively induces osteoblastic differentiation of MC3T3-E1 cells via the activation of Runx2 and osterix and is dependent upon the protein kinase C (PKC) pathways. We further demonstrated that prolonged activation of PKC pathways is sufficient to induce osteoblastic differentiation, possibly via the activation of PKD/PKCμ. © 2005 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.en_HK
dc.languageengen_HK
dc.publisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/febsleten_HK
dc.relation.ispartofFEBS Lettersen_HK
dc.rightsF E B S Letters. Copyright © Elsevier BV.en_HK
dc.subjectDMSO-
dc.subjectErk-
dc.subjectOsteoblasts-
dc.subjectPKD-
dc.subjectProliferation-
dc.subjectProtein kinase C-
dc.subject.meshAnimalsen_HK
dc.subject.meshCell Differentiation - drug effectsen_HK
dc.subject.meshCell Lineen_HK
dc.subject.meshCore Binding Factor Alpha 1 Subunit - metabolismen_HK
dc.subject.meshDimethyl Sulfoxide - pharmacologyen_HK
dc.subject.meshEnzyme Activation - drug effectsen_HK
dc.subject.meshMiceen_HK
dc.subject.meshOsteoblasts - enzymologyen_HK
dc.subject.meshProtein Kinase C - metabolismen_HK
dc.subject.meshSignal Transduction - drug effectsen_HK
dc.subject.meshSolvents - pharmacologyen_HK
dc.titleDimethyl sulfoxide as an inducer of differentiation in preosteoblast MC3T3-E1 cellsen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0014-5793&volume=580&spage=121&epage=6&date=2006&atitle=Dimethyl+sulfoxide+as+an+inducer+of+differentiation+in+preosteoblast+MC3T3-E1+cellsen_HK
dc.identifier.emailKung, AWC:awckung@hku.hken_HK
dc.identifier.authorityKung, AWC=rp00368en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.febslet.2005.11.062en_HK
dc.identifier.pmid16360153-
dc.identifier.scopuseid_2-s2.0-29344435159en_HK
dc.identifier.hkuros114782en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-29344435159&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume580en_HK
dc.identifier.issue1en_HK
dc.identifier.spage121en_HK
dc.identifier.epage126en_HK
dc.identifier.isiWOS:000234605100022-
dc.publisher.placeNetherlandsen_HK
dc.identifier.scopusauthoridCheung, WMW=7202743069en_HK
dc.identifier.scopusauthoridNg, WW=7401613617en_HK
dc.identifier.scopusauthoridKung, AWC=7102322339en_HK
dc.identifier.issnl0014-5793-

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