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Article: CYP2C9 polymorphism in non-steroidal anti-inflammatory drugs-induced gastropathy

TitleCYP2C9 polymorphism in non-steroidal anti-inflammatory drugs-induced gastropathy
Authors
Keywords2
3
CYP2C9
CYP2C9 genotype
Non-steroidal anti-inflammatory drugs
NSAID-induced gastropathy
Issue Date2008
PublisherBlackwell Publishing Asia. The Journal's web site is located at http://www.blackwellpublishing.com/journal.asp?ref=1443-9611&site=1
Citation
Journal Of Digestive Diseases, 2008, v. 9 n. 2, p. 79-83 How to Cite?
AbstractObjective: Non-steroidal anti-inflammatory drugs (NSAID) induce gastroduodenal mucosal injury and are metabolized by cytochrome P450 2C9 (CYP2C9). It is postulated that CYP2C9 genotype is associated with NSAID-induced gastropathy. This study aims to determine whether individuals with a CYP2C9 allele mutation are susceptible to NSAID-induced gastropathy. Methods: A total of 109 patients diagnosed as having rheumatic diseases and taking NSAID were appraised as having gastropathy by endoscopy, stool occult blood test and questionnaire two weeks after entering the study. Their peripheral blood was analyzed by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). Results: A total of 47.7% gastropathy (33% erosions, 14.7% ulcers, 2.75% ulcer bleeding) and 56% dyspeptic symptoms were presented. Only one CYP2C9*2 heterozygote (*1/*2) was found in the group with gastropathy and two variant alleles (CYP2C9*2 and CYP2C9*3) could not be found in the group without gastropathy. There was no significant difference in both CYP2C9 genotype (0.96% vs 0%) and CYP2C9 variant allele frequency (1.92% vs 0%) between patients with and without gastropathy. Conclusion: These results confirm the high prevalence of NSAID-induced gastropathy but do not support the postulation that CYP2C9*2 and CYP2C9*3 contribute to the development of NSAID-induced gastropathy. This may be due to the low frequency of the two alleles in the population studied. © 2008 The Authors Journal compilation © 2008 Chinese Medical Association Shanghai Branch, Chinese Society of Gastroenterology and Blackwell Publishing Asia Pty Ltd.
Persistent Identifierhttp://hdl.handle.net/10722/76536
ISSN
2015 Impact Factor: 1.887
2015 SCImago Journal Rankings: 0.781
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorMa, Jen_HK
dc.contributor.authorYang, XYen_HK
dc.contributor.authorQiao, Len_HK
dc.contributor.authorLiang, LQen_HK
dc.contributor.authorChen, MHen_HK
dc.date.accessioned2010-09-06T07:22:17Z-
dc.date.available2010-09-06T07:22:17Z-
dc.date.issued2008en_HK
dc.identifier.citationJournal Of Digestive Diseases, 2008, v. 9 n. 2, p. 79-83en_HK
dc.identifier.issn1751-2972en_HK
dc.identifier.urihttp://hdl.handle.net/10722/76536-
dc.description.abstractObjective: Non-steroidal anti-inflammatory drugs (NSAID) induce gastroduodenal mucosal injury and are metabolized by cytochrome P450 2C9 (CYP2C9). It is postulated that CYP2C9 genotype is associated with NSAID-induced gastropathy. This study aims to determine whether individuals with a CYP2C9 allele mutation are susceptible to NSAID-induced gastropathy. Methods: A total of 109 patients diagnosed as having rheumatic diseases and taking NSAID were appraised as having gastropathy by endoscopy, stool occult blood test and questionnaire two weeks after entering the study. Their peripheral blood was analyzed by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). Results: A total of 47.7% gastropathy (33% erosions, 14.7% ulcers, 2.75% ulcer bleeding) and 56% dyspeptic symptoms were presented. Only one CYP2C9*2 heterozygote (*1/*2) was found in the group with gastropathy and two variant alleles (CYP2C9*2 and CYP2C9*3) could not be found in the group without gastropathy. There was no significant difference in both CYP2C9 genotype (0.96% vs 0%) and CYP2C9 variant allele frequency (1.92% vs 0%) between patients with and without gastropathy. Conclusion: These results confirm the high prevalence of NSAID-induced gastropathy but do not support the postulation that CYP2C9*2 and CYP2C9*3 contribute to the development of NSAID-induced gastropathy. This may be due to the low frequency of the two alleles in the population studied. © 2008 The Authors Journal compilation © 2008 Chinese Medical Association Shanghai Branch, Chinese Society of Gastroenterology and Blackwell Publishing Asia Pty Ltd.en_HK
dc.languageengen_HK
dc.publisherBlackwell Publishing Asia. The Journal's web site is located at http://www.blackwellpublishing.com/journal.asp?ref=1443-9611&site=1en_HK
dc.relation.ispartofJournal of Digestive Diseasesen_HK
dc.subject2en_HK
dc.subject3en_HK
dc.subjectCYP2C9en_HK
dc.subjectCYP2C9 genotypeen_HK
dc.subjectNon-steroidal anti-inflammatory drugsen_HK
dc.subjectNSAID-induced gastropathyen_HK
dc.subject.meshGastrointestinal Diseases - chemically induced - ethnology - genetics-
dc.subject.meshGenetic Predisposition to Disease - genetics-
dc.subject.meshPolymorphism, Genetic - genetics-
dc.subject.meshAdolescent-
dc.subject.meshAdult-
dc.titleCYP2C9 polymorphism in non-steroidal anti-inflammatory drugs-induced gastropathyen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1751-2972&volume=9&spage=79&epage=84&date=2008&atitle=CYP2C9+polymorphism+in+non-steroidal+anti-inflammatory+drugs-induced+gastropathyen_HK
dc.identifier.emailQiao, L: lq8688@hotmail.comen_HK
dc.identifier.authorityQiao, L=rp00513en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1111/j.1751-2980.2008.00326.xen_HK
dc.identifier.pmid18419640-
dc.identifier.scopuseid_2-s2.0-42449136588en_HK
dc.identifier.hkuros145030en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-42449136588&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume9en_HK
dc.identifier.issue2en_HK
dc.identifier.spage79en_HK
dc.identifier.epage83en_HK
dc.identifier.isiWOS:000256983200004-
dc.publisher.placeAustraliaen_HK
dc.identifier.scopusauthoridMa, J=35275386200en_HK
dc.identifier.scopusauthoridYang, XY=15062127700en_HK
dc.identifier.scopusauthoridQiao, L=7202151719en_HK
dc.identifier.scopusauthoridLiang, LQ=15061432400en_HK
dc.identifier.scopusauthoridChen, MH=8642044500en_HK

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