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Article: Helicobacter pylori and upper gastrointestinal symptoms in bronchiectasis

TitleHelicobacter pylori and upper gastrointestinal symptoms in bronchiectasis
Authors
Issue Date1999
PublisherEuropean Respiratory Society. The Journal's web site is located at http://erj.ersjournals.com
Citation
European Respiratory Journal, 1999, v. 14 n. 6, p. 1345-1350 How to Cite?
AbstractThe recently reported increase in seroprevalence of Helicobacter pylori, the causative pathogen in peptic ulceration, in bronchiectasis is unexplained. Therefore, the association of antibodies directed against cytotoxin-associated gene A(CagA), whose expression indicates virulence of H. pylori, and upper gastrointestinal symptoms in patients with stable bronchiectasis and healthy volunteers evaluated. One hundred patients (mean±SD age 55.1±16.7 yrs) and 94 healthy asymptomatic subjects (54.6±7.6 yrs) underwent clinical and physiological assessment and serum levels of anti-H. pylori CagA immunoglobulin G level and forced expiratory volume in one second (FEV1), forced vital capacity (FVC), sputum volume, respiratory symptoms or upper respiratory gastrointestinal symptoms (p>0.05). Patients who suffered from acid regurgitation or upper abdominal distention had significantly lower FEV1 and FVC (as a percentage of the predicted value) compared to their counterparts. The results of anticytotoxin-associated gene A measurements in this study contrasted with the previous finding that anti- Helicobacter pylori immunoglobulin G correlated it have a pathogenic role in bronchiectasis, could act via noncytotoxin-associated gene A-mediated mechanisms, and, in this context, gastro-oesophageal reflux might be of importance in bronchiectasis.
Persistent Identifierhttp://hdl.handle.net/10722/76527
ISSN
2015 Impact Factor: 8.332
2015 SCImago Journal Rankings: 3.204
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorTsang, KWen_HK
dc.contributor.authorLam, WKen_HK
dc.contributor.authorKwok, Een_HK
dc.contributor.authorChan, KNen_HK
dc.contributor.authorHu, WHCen_HK
dc.contributor.authorOoi, GCen_HK
dc.contributor.authorZheng, Len_HK
dc.contributor.authorWong, BCYen_HK
dc.contributor.authorLam, SKen_HK
dc.date.accessioned2010-09-06T07:22:11Z-
dc.date.available2010-09-06T07:22:11Z-
dc.date.issued1999en_HK
dc.identifier.citationEuropean Respiratory Journal, 1999, v. 14 n. 6, p. 1345-1350en_HK
dc.identifier.issn0903-1936en_HK
dc.identifier.urihttp://hdl.handle.net/10722/76527-
dc.description.abstractThe recently reported increase in seroprevalence of Helicobacter pylori, the causative pathogen in peptic ulceration, in bronchiectasis is unexplained. Therefore, the association of antibodies directed against cytotoxin-associated gene A(CagA), whose expression indicates virulence of H. pylori, and upper gastrointestinal symptoms in patients with stable bronchiectasis and healthy volunteers evaluated. One hundred patients (mean±SD age 55.1±16.7 yrs) and 94 healthy asymptomatic subjects (54.6±7.6 yrs) underwent clinical and physiological assessment and serum levels of anti-H. pylori CagA immunoglobulin G level and forced expiratory volume in one second (FEV1), forced vital capacity (FVC), sputum volume, respiratory symptoms or upper respiratory gastrointestinal symptoms (p>0.05). Patients who suffered from acid regurgitation or upper abdominal distention had significantly lower FEV1 and FVC (as a percentage of the predicted value) compared to their counterparts. The results of anticytotoxin-associated gene A measurements in this study contrasted with the previous finding that anti- Helicobacter pylori immunoglobulin G correlated it have a pathogenic role in bronchiectasis, could act via noncytotoxin-associated gene A-mediated mechanisms, and, in this context, gastro-oesophageal reflux might be of importance in bronchiectasis.en_HK
dc.languageengen_HK
dc.publisherEuropean Respiratory Society. The Journal's web site is located at http://erj.ersjournals.comen_HK
dc.relation.ispartofEuropean Respiratory Journalen_HK
dc.subject.meshAdulten_HK
dc.subject.meshAgeden_HK
dc.subject.meshAntigens, Bacterialen_HK
dc.subject.meshBacterial Proteins - analysisen_HK
dc.subject.meshBronchiectasis - complications - diagnosisen_HK
dc.subject.meshChi-Square Distributionen_HK
dc.subject.meshCohort Studiesen_HK
dc.subject.meshFemaleen_HK
dc.subject.meshGastrointestinal Diseases - diagnosis - etiologyen_HK
dc.subject.meshGenes, Bacterialen_HK
dc.subject.meshHelicobacter Infections - diagnosis - etiologyen_HK
dc.subject.meshHelicobacter pylori - genetics - isolation & purificationen_HK
dc.subject.meshHumansen_HK
dc.subject.meshMaleen_HK
dc.subject.meshMiddle Ageden_HK
dc.subject.meshReference Valuesen_HK
dc.subject.meshRespiratory Function Testsen_HK
dc.subject.meshStatistics, Nonparametricen_HK
dc.titleHelicobacter pylori and upper gastrointestinal symptoms in bronchiectasisen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0903-1936&volume=14 &issue=6&spage=1345&epage=50&date=1999&atitle=Helicobacter+pylori+and+upper+gastrointestinal+symptoms+in+bronchiectasisen_HK
dc.identifier.emailWong, BCY:bcywong@hku.hken_HK
dc.identifier.authorityWong, BCY=rp00429en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.pmid10624765-
dc.identifier.scopuseid_2-s2.0-0033394969en_HK
dc.identifier.hkuros49983en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0033394969&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume14en_HK
dc.identifier.issue6en_HK
dc.identifier.spage1345en_HK
dc.identifier.epage1350en_HK
dc.identifier.isiWOS:000084385900018-
dc.publisher.placeSwitzerlanden_HK
dc.identifier.scopusauthoridTsang, KW=7201555024en_HK
dc.identifier.scopusauthoridLam, WK=7203021937en_HK
dc.identifier.scopusauthoridKwok, E=7005571440en_HK
dc.identifier.scopusauthoridChan, KN=15737866400en_HK
dc.identifier.scopusauthoridHu, WHC=25932937100en_HK
dc.identifier.scopusauthoridOoi, GC=7006176119en_HK
dc.identifier.scopusauthoridZheng, L=7403404086en_HK
dc.identifier.scopusauthoridWong, BCY=7402023340en_HK
dc.identifier.scopusauthoridLam, SK=7402279473en_HK

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