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- Publisher Website: 10.1183/09031936.99.14613459
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- PMID: 10624765
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Article: Helicobacter pylori and upper gastrointestinal symptoms in bronchiectasis
Title | Helicobacter pylori and upper gastrointestinal symptoms in bronchiectasis |
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Authors | |
Keywords | Acid regurgitation Bronchiectasis Cytotoxin-associated gene A Gastrointestinal symptoms Helicobacter pylori |
Issue Date | 1999 |
Publisher | European Respiratory Society. The Journal's web site is located at http://erj.ersjournals.com |
Citation | European Respiratory Journal, 1999, v. 14 n. 6, p. 1345-1350 How to Cite? |
Abstract | The recently reported increase in seroprevalence of Helicobacter pylori, the causative pathogen in peptic ulceration, in bronchiectasis is unexplained. Therefore, the association of antibodies directed against cytotoxin-associated gene A(CagA), whose expression indicates virulence of H. pylori, and upper gastrointestinal symptoms in patients with stable bronchiectasis and healthy volunteers evaluated. One hundred patients (mean±SD age 55.1±16.7 yrs) and 94 healthy asymptomatic subjects (54.6±7.6 yrs) underwent clinical and physiological assessment and serum levels of anti-H. pylori CagA immunoglobulin G level and forced expiratory volume in one second (FEV1), forced vital capacity (FVC), sputum volume, respiratory symptoms or upper respiratory gastrointestinal symptoms (p>0.05). Patients who suffered from acid regurgitation or upper abdominal distention had significantly lower FEV1 and FVC (as a percentage of the predicted value) compared to their counterparts. The results of anticytotoxin-associated gene A measurements in this study contrasted with the previous finding that anti- Helicobacter pylori immunoglobulin G correlated it have a pathogenic role in bronchiectasis, could act via noncytotoxin-associated gene A-mediated mechanisms, and, in this context, gastro-oesophageal reflux might be of importance in bronchiectasis. |
Persistent Identifier | http://hdl.handle.net/10722/76527 |
ISSN | 2023 Impact Factor: 16.6 2023 SCImago Journal Rankings: 3.810 |
ISI Accession Number ID | |
References |
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Tsang, KW | en_HK |
dc.contributor.author | Lam, WK | en_HK |
dc.contributor.author | Kwok, E | en_HK |
dc.contributor.author | Chan, KN | en_HK |
dc.contributor.author | Hu, WHC | en_HK |
dc.contributor.author | Ooi, GC | en_HK |
dc.contributor.author | Zheng, L | en_HK |
dc.contributor.author | Wong, BCY | en_HK |
dc.contributor.author | Lam, SK | en_HK |
dc.date.accessioned | 2010-09-06T07:22:11Z | - |
dc.date.available | 2010-09-06T07:22:11Z | - |
dc.date.issued | 1999 | en_HK |
dc.identifier.citation | European Respiratory Journal, 1999, v. 14 n. 6, p. 1345-1350 | en_HK |
dc.identifier.issn | 0903-1936 | en_HK |
dc.identifier.uri | http://hdl.handle.net/10722/76527 | - |
dc.description.abstract | The recently reported increase in seroprevalence of Helicobacter pylori, the causative pathogen in peptic ulceration, in bronchiectasis is unexplained. Therefore, the association of antibodies directed against cytotoxin-associated gene A(CagA), whose expression indicates virulence of H. pylori, and upper gastrointestinal symptoms in patients with stable bronchiectasis and healthy volunteers evaluated. One hundred patients (mean±SD age 55.1±16.7 yrs) and 94 healthy asymptomatic subjects (54.6±7.6 yrs) underwent clinical and physiological assessment and serum levels of anti-H. pylori CagA immunoglobulin G level and forced expiratory volume in one second (FEV1), forced vital capacity (FVC), sputum volume, respiratory symptoms or upper respiratory gastrointestinal symptoms (p>0.05). Patients who suffered from acid regurgitation or upper abdominal distention had significantly lower FEV1 and FVC (as a percentage of the predicted value) compared to their counterparts. The results of anticytotoxin-associated gene A measurements in this study contrasted with the previous finding that anti- Helicobacter pylori immunoglobulin G correlated it have a pathogenic role in bronchiectasis, could act via noncytotoxin-associated gene A-mediated mechanisms, and, in this context, gastro-oesophageal reflux might be of importance in bronchiectasis. | en_HK |
dc.language | eng | en_HK |
dc.publisher | European Respiratory Society. The Journal's web site is located at http://erj.ersjournals.com | en_HK |
dc.relation.ispartof | European Respiratory Journal | en_HK |
dc.subject | Acid regurgitation | - |
dc.subject | Bronchiectasis | - |
dc.subject | Cytotoxin-associated gene A | - |
dc.subject | Gastrointestinal symptoms | - |
dc.subject | Helicobacter pylori | - |
dc.subject.mesh | Adult | en_HK |
dc.subject.mesh | Aged | en_HK |
dc.subject.mesh | Antigens, Bacterial | en_HK |
dc.subject.mesh | Bacterial Proteins - analysis | en_HK |
dc.subject.mesh | Bronchiectasis - complications - diagnosis | en_HK |
dc.subject.mesh | Chi-Square Distribution | en_HK |
dc.subject.mesh | Cohort Studies | en_HK |
dc.subject.mesh | Female | en_HK |
dc.subject.mesh | Gastrointestinal Diseases - diagnosis - etiology | en_HK |
dc.subject.mesh | Genes, Bacterial | en_HK |
dc.subject.mesh | Helicobacter Infections - diagnosis - etiology | en_HK |
dc.subject.mesh | Helicobacter pylori - genetics - isolation & purification | en_HK |
dc.subject.mesh | Humans | en_HK |
dc.subject.mesh | Male | en_HK |
dc.subject.mesh | Middle Aged | en_HK |
dc.subject.mesh | Reference Values | en_HK |
dc.subject.mesh | Respiratory Function Tests | en_HK |
dc.subject.mesh | Statistics, Nonparametric | en_HK |
dc.title | Helicobacter pylori and upper gastrointestinal symptoms in bronchiectasis | en_HK |
dc.type | Article | en_HK |
dc.identifier.openurl | http://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0903-1936&volume=14 &issue=6&spage=1345&epage=50&date=1999&atitle=Helicobacter+pylori+and+upper+gastrointestinal+symptoms+in+bronchiectasis | en_HK |
dc.identifier.email | Wong, BCY:bcywong@hku.hk | en_HK |
dc.identifier.authority | Wong, BCY=rp00429 | en_HK |
dc.description.nature | link_to_subscribed_fulltext | - |
dc.identifier.doi | 10.1183/09031936.99.14613459 | - |
dc.identifier.pmid | 10624765 | - |
dc.identifier.scopus | eid_2-s2.0-0033394969 | en_HK |
dc.identifier.hkuros | 49983 | en_HK |
dc.relation.references | http://www.scopus.com/mlt/select.url?eid=2-s2.0-0033394969&selection=ref&src=s&origin=recordpage | en_HK |
dc.identifier.volume | 14 | en_HK |
dc.identifier.issue | 6 | en_HK |
dc.identifier.spage | 1345 | en_HK |
dc.identifier.epage | 1350 | en_HK |
dc.identifier.isi | WOS:000084385900018 | - |
dc.publisher.place | Switzerland | en_HK |
dc.identifier.scopusauthorid | Tsang, KW=7201555024 | en_HK |
dc.identifier.scopusauthorid | Lam, WK=7203021937 | en_HK |
dc.identifier.scopusauthorid | Kwok, E=7005571440 | en_HK |
dc.identifier.scopusauthorid | Chan, KN=15737866400 | en_HK |
dc.identifier.scopusauthorid | Hu, WHC=25932937100 | en_HK |
dc.identifier.scopusauthorid | Ooi, GC=7006176119 | en_HK |
dc.identifier.scopusauthorid | Zheng, L=7403404086 | en_HK |
dc.identifier.scopusauthorid | Wong, BCY=7402023340 | en_HK |
dc.identifier.scopusauthorid | Lam, SK=7402279473 | en_HK |
dc.identifier.issnl | 0903-1936 | - |