File Download

There are no files associated with this item.

  Links for fulltext
     (May Require Subscription)
Supplementary

Article: Differential helicobacter pylori infection rates in two contrasting gastric cancer risk regions of South China

TitleDifferential helicobacter pylori infection rates in two contrasting gastric cancer risk regions of South China
Authors
Issue Date1999
PublisherWiley-Blackwell Publishing Asia. The Journal's web site is located at http://www.blackwellpublishing.com/journals/JGH
Citation
Journal Of Gastroenterology And Hepatology, 1999, v. 14 n. 2, p. 120-125 How to Cite?
AbstractBackground: Carriers of Helicobacter pylori are believed to have a three- to six-fold increased risk of developing gastric cancer. We have recently conducted a simultaneous cross-sectional population study on the prevalence of H. pylori infection in a cohort of asymptomatic adult volunteers in two contrasting gastric cancer risk regions of South China, Hong Kong and Changle of Fujian. Their mean annual gastric cancer mortality has been approximately 7.5 and 75/100 000 population, respectively, since the beginning of the last decade. The aim of this study was to evaluate if H. pylori prevalence bears any relationship to gastric cancer mortality rates in these two southern regions of China. Methods: Sera were obtained from 397 volunteers in Hong Kong. They were tested for anti-H. pylori immunoglobulin (Ig) G antibody by using a commercial enzyme-linked immunosorbent assay (ELISA) kit. Volunteers of Changle (1456) had upper endoscopy examination and were also tested for anti-H. pylori IgG antibody by the same ELISA method. Results: The overall H. pylori infection prevalence was significantly higher in Changle (80.4%) than in Hong Kong (58.4%; P < 0.01). The high prevalence is associated with more atrophic gastritis. The overall risk of gastric cancer in people of Changle is approximately five-fold that of Hong Kong (adjusted odds ratio 4.9, 95% CI 2.5-9.8). Conclusions: It is concluded that the prevalence of H. pylori infection rates bear a direct relationship to gastric cancer mortality rates in these two southern regions of China. Thus, H. pylori most likely pays a significant aetiopathogenetic role in gastric carcinogenesis in subjects living in Changle.
Persistent Identifierhttp://hdl.handle.net/10722/76496
ISSN
2015 Impact Factor: 3.322
2015 SCImago Journal Rankings: 1.190
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorWong, BCYen_HK
dc.contributor.authorLam, SKen_HK
dc.contributor.authorChing, CKen_HK
dc.contributor.authorHu, WHCen_HK
dc.contributor.authorKwok, Een_HK
dc.contributor.authorHo, Jen_HK
dc.contributor.authorYuen, STen_HK
dc.contributor.authorGao, Zen_HK
dc.contributor.authorChen, JSen_HK
dc.contributor.authorLai, KCen_HK
dc.contributor.authorOng, LYen_HK
dc.contributor.authorChen, BWen_HK
dc.contributor.authorWang, WHen_HK
dc.contributor.authorJiang, XWen_HK
dc.contributor.authorHou, XHen_HK
dc.contributor.authorLu, JYen_HK
dc.contributor.authorLin, CQen_HK
dc.contributor.authorWu, JPen_HK
dc.contributor.authorChen, XCen_HK
dc.contributor.authorLin, ZCen_HK
dc.contributor.authorChong, Men_HK
dc.contributor.authorFan, YCen_HK
dc.contributor.authorLee, HSen_HK
dc.contributor.authorWong, KWen_HK
dc.contributor.authorTang, SYen_HK
dc.contributor.authorLee, MYen_HK
dc.contributor.authorTsang, Cen_HK
dc.contributor.authorWong, Aen_HK
dc.date.accessioned2010-09-06T07:21:51Z-
dc.date.available2010-09-06T07:21:51Z-
dc.date.issued1999en_HK
dc.identifier.citationJournal Of Gastroenterology And Hepatology, 1999, v. 14 n. 2, p. 120-125en_HK
dc.identifier.issn0815-9319en_HK
dc.identifier.urihttp://hdl.handle.net/10722/76496-
dc.description.abstractBackground: Carriers of Helicobacter pylori are believed to have a three- to six-fold increased risk of developing gastric cancer. We have recently conducted a simultaneous cross-sectional population study on the prevalence of H. pylori infection in a cohort of asymptomatic adult volunteers in two contrasting gastric cancer risk regions of South China, Hong Kong and Changle of Fujian. Their mean annual gastric cancer mortality has been approximately 7.5 and 75/100 000 population, respectively, since the beginning of the last decade. The aim of this study was to evaluate if H. pylori prevalence bears any relationship to gastric cancer mortality rates in these two southern regions of China. Methods: Sera were obtained from 397 volunteers in Hong Kong. They were tested for anti-H. pylori immunoglobulin (Ig) G antibody by using a commercial enzyme-linked immunosorbent assay (ELISA) kit. Volunteers of Changle (1456) had upper endoscopy examination and were also tested for anti-H. pylori IgG antibody by the same ELISA method. Results: The overall H. pylori infection prevalence was significantly higher in Changle (80.4%) than in Hong Kong (58.4%; P < 0.01). The high prevalence is associated with more atrophic gastritis. The overall risk of gastric cancer in people of Changle is approximately five-fold that of Hong Kong (adjusted odds ratio 4.9, 95% CI 2.5-9.8). Conclusions: It is concluded that the prevalence of H. pylori infection rates bear a direct relationship to gastric cancer mortality rates in these two southern regions of China. Thus, H. pylori most likely pays a significant aetiopathogenetic role in gastric carcinogenesis in subjects living in Changle.en_HK
dc.languageengen_HK
dc.publisherWiley-Blackwell Publishing Asia. The Journal's web site is located at http://www.blackwellpublishing.com/journals/JGHen_HK
dc.relation.ispartofJournal of Gastroenterology and Hepatologyen_HK
dc.subject.meshAdulten_HK
dc.subject.meshAgeden_HK
dc.subject.meshAged, 80 and overen_HK
dc.subject.meshAntibodies, Bacterial - analysisen_HK
dc.subject.meshCross-Sectional Studiesen_HK
dc.subject.meshEndoscopy, Digestive Systemen_HK
dc.subject.meshEnzyme-Linked Immunosorbent Assayen_HK
dc.subject.meshFemaleen_HK
dc.subject.meshHelicobacter Infections - complications - diagnosis - epidemiologyen_HK
dc.subject.meshHelicobacter pylori - immunologyen_HK
dc.subject.meshHong Kong - epidemiologyen_HK
dc.subject.meshHumansen_HK
dc.subject.meshImmunoglobulin G - immunologyen_HK
dc.subject.meshIncidenceen_HK
dc.subject.meshMaleen_HK
dc.subject.meshMiddle Ageden_HK
dc.subject.meshPrevalenceen_HK
dc.subject.meshRegistries - statistics & numerical dataen_HK
dc.subject.meshRetrospective Studiesen_HK
dc.subject.meshSex Factorsen_HK
dc.subject.meshStomach Neoplasms - diagnosis - epidemiology - microbiologyen_HK
dc.subject.meshSurvival Rateen_HK
dc.titleDifferential helicobacter pylori infection rates in two contrasting gastric cancer risk regions of South Chinaen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0815-9319&volume=14&spage=120&epage=125&date=1999&atitle=Differential+Helicobacter+pylori+infection+rates+in+two+contrasting+gastric+cancer+risk+regions+of+South+Chinaen_HK
dc.identifier.emailWong, BCY:bcywong@hku.hken_HK
dc.identifier.authorityWong, BCY=rp00429en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1046/j.1440-1746.1999.01823.xen_HK
dc.identifier.pmid10029291-
dc.identifier.scopuseid_2-s2.0-0032934172en_HK
dc.identifier.hkuros46451en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0032934172&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume14en_HK
dc.identifier.issue2en_HK
dc.identifier.spage120en_HK
dc.identifier.epage125en_HK
dc.identifier.isiWOS:000078787900004-
dc.publisher.placeAustraliaen_HK
dc.identifier.scopusauthoridWong, BCY=7402023340en_HK
dc.identifier.scopusauthoridLam, SK=7402279473en_HK
dc.identifier.scopusauthoridChing, CK=7102130825en_HK
dc.identifier.scopusauthoridHu, WHC=25932937100en_HK
dc.identifier.scopusauthoridKwok, E=7005571440en_HK
dc.identifier.scopusauthoridHo, J=15029093800en_HK
dc.identifier.scopusauthoridYuen, ST=7103160927en_HK
dc.identifier.scopusauthoridGao, Z=19733331900en_HK
dc.identifier.scopusauthoridChen, JS=34771081100en_HK
dc.identifier.scopusauthoridLai, KC=7402135595en_HK
dc.identifier.scopusauthoridOng, LY=8091873900en_HK
dc.identifier.scopusauthoridChen, BW=7408610379en_HK
dc.identifier.scopusauthoridWang, WH=23390847100en_HK
dc.identifier.scopusauthoridJiang, XW=7404627650en_HK
dc.identifier.scopusauthoridHou, XH=7402838898en_HK
dc.identifier.scopusauthoridLu, JY=35225876600en_HK
dc.identifier.scopusauthoridLin, CQ=20234804400en_HK
dc.identifier.scopusauthoridWu, JP=8311041800en_HK
dc.identifier.scopusauthoridChen, XC=15031419100en_HK
dc.identifier.scopusauthoridLin, ZC=20234822400en_HK
dc.identifier.scopusauthoridChong, M=20233576800en_HK
dc.identifier.scopusauthoridFan, YC=20234113600en_HK
dc.identifier.scopusauthoridLee, HS=16430011900en_HK
dc.identifier.scopusauthoridWong, KW=35118458300en_HK
dc.identifier.scopusauthoridTang, SY=14036630800en_HK
dc.identifier.scopusauthoridLee, MY=20234919900en_HK
dc.identifier.scopusauthoridTsang, C=20236300000en_HK
dc.identifier.scopusauthoridWong, A=55118835600en_HK

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats