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Conference Paper: The outcomes of thyrotoxicosis related new-onset atrial fibrillation

TitleThe outcomes of thyrotoxicosis related new-onset atrial fibrillation
Authors
Issue Date2006
PublisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/jac
Citation
The 55th Annual Scientific Session of the American College of Cardiology (ACC 2006), Atlanta, GA., 11-14 March 2006. In Journal of the American College of Cardiology, 2006, v. 47 n. 4 suppl. 1, p. 10A, abstract no. 804-5 How to Cite?
AbstractINTRODUCTION: Although thyrotoxicosis (TT) is a common cause for atrial fibrillation (AF), the clinical outcomes of TT related new onset persistent AF remains unclear. METHODS AND RESULTS: Over 10-year period, 215 patients (pts) with TT with new onset-AF were studied. 15 pts with pre-existing heart diseases were excluded. Among 200 pts with TT related AF, their mean age was 64±17 years (41% male). At presentation, 14 pts (7%) had concomitant ischemic stroke (IS) and 77 pts (39%) developed congestive cardiac failure (CCF). Pts with IS had a higher prevalence of hypertension (HT) than those without IS (50 vs. 25%,p=0.04), but had no difference in age and sex (p>0.05). After mean follow-up of 45±37 months, 100 pts (50%) had spontaneous cardioversion (CV) at median time of 23 days. The median time to euthyroidism with anti-thyroid drug was 81 days. In univariate analysis, there were no significant differences in pts with or without CV with respect to age, male gender and diabetes (Table). However, pts without CV had a higher prevalence of HT and CCF at the time of presentation, lower usage of beta-blockers, larger left atrial (LA) and left ventricular (LV) size, and lower ejection fraction (EF) than those with CV (Table, P<0.05). Multivariate analysis demonstrated only LA is the independent predictor for CV (OR=3.9, P=0.01). CONCLUSION: TT related AF is related to high incidence of IS and CCF at presentation. After control of TT, spontaneous CV can occur in up to 50% pts. The sole independent predictors of CV is smaller LA.
Persistent Identifierhttp://hdl.handle.net/10722/76488
ISSN
2015 Impact Factor: 17.759
2015 SCImago Journal Rankings: 10.097

 

DC FieldValueLanguage
dc.contributor.authorSiu, CWDen_HK
dc.contributor.authorJim, MHen_HK
dc.contributor.authorKung, AWCen_HK
dc.contributor.authorLau, CPen_HK
dc.contributor.authorTse, HFen_HK
dc.date.accessioned2010-09-06T07:21:46Z-
dc.date.available2010-09-06T07:21:46Z-
dc.date.issued2006en_HK
dc.identifier.citationThe 55th Annual Scientific Session of the American College of Cardiology (ACC 2006), Atlanta, GA., 11-14 March 2006. In Journal of the American College of Cardiology, 2006, v. 47 n. 4 suppl. 1, p. 10A, abstract no. 804-5en_HK
dc.identifier.issn0735-1097en_HK
dc.identifier.urihttp://hdl.handle.net/10722/76488-
dc.description.abstractINTRODUCTION: Although thyrotoxicosis (TT) is a common cause for atrial fibrillation (AF), the clinical outcomes of TT related new onset persistent AF remains unclear. METHODS AND RESULTS: Over 10-year period, 215 patients (pts) with TT with new onset-AF were studied. 15 pts with pre-existing heart diseases were excluded. Among 200 pts with TT related AF, their mean age was 64±17 years (41% male). At presentation, 14 pts (7%) had concomitant ischemic stroke (IS) and 77 pts (39%) developed congestive cardiac failure (CCF). Pts with IS had a higher prevalence of hypertension (HT) than those without IS (50 vs. 25%,p=0.04), but had no difference in age and sex (p>0.05). After mean follow-up of 45±37 months, 100 pts (50%) had spontaneous cardioversion (CV) at median time of 23 days. The median time to euthyroidism with anti-thyroid drug was 81 days. In univariate analysis, there were no significant differences in pts with or without CV with respect to age, male gender and diabetes (Table). However, pts without CV had a higher prevalence of HT and CCF at the time of presentation, lower usage of beta-blockers, larger left atrial (LA) and left ventricular (LV) size, and lower ejection fraction (EF) than those with CV (Table, P<0.05). Multivariate analysis demonstrated only LA is the independent predictor for CV (OR=3.9, P=0.01). CONCLUSION: TT related AF is related to high incidence of IS and CCF at presentation. After control of TT, spontaneous CV can occur in up to 50% pts. The sole independent predictors of CV is smaller LA.-
dc.languageengen_HK
dc.publisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/jacen_HK
dc.relation.ispartofJournal of the American College of Cardiologyen_HK
dc.rightsJournal of the American College of Cardiology. Copyright © Elsevier Inc.en_HK
dc.titleThe outcomes of thyrotoxicosis related new-onset atrial fibrillationen_HK
dc.typeConference_Paperen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0735-1097&volume=47&spage=10A&epage=&date=2006&atitle=The+Outcomes+of+Thyrotoxicosis+Related+New-Onset+Atrial+Fibrillationen_HK
dc.identifier.emailKung, AWC: awckung@hku.hken_HK
dc.identifier.emailLau, CP: cplau@hku.hken_HK
dc.identifier.emailTse, HF: hftse@hkucc.hku.hken_HK
dc.identifier.authorityKung, AWC=rp00368en_HK
dc.identifier.authorityTse, HF=rp00428en_HK
dc.identifier.doi10.1016/j.jacc.2006.01.011-
dc.identifier.hkuros116916en_HK
dc.identifier.volume47-
dc.identifier.issue4 suppl. 1-
dc.identifier.spage10A, abstract no. 804-5-
dc.identifier.epage10A, abstract no. 804-5-
dc.description.otherThe American College of Cardiology 55th Annual Scientific Session, Atlanta, Ga, USA, 11-14 March 2006. In Journal of the American College of Cardiology, 2006, v. 47 n. 4 Suppl. 1, p. 10A, abstract no. 804-5-

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