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Article: Hepatitis C virus infection in adult Chinese hemophilia patients negative for the human immunodeficiency virus: Treatment results with interferon and ribavirin

TitleHepatitis C virus infection in adult Chinese hemophilia patients negative for the human immunodeficiency virus: Treatment results with interferon and ribavirin
Authors
Issue Date2005
PublisherSpringer Japan KK.
Citation
International Journal Of Hematology, 2005, v. 82 n. 3, p. 259-261 How to Cite?
AbstractHepatitis C virus (HCV) eradication in hemophilia patients depends on viral and patient factors. We report the treatment results with interferon α (5 megaunits, 3 times per week) and ribavirin (1 g daily) for 1 year in 17 Chinese patients who were negative for the human immunodeficiency virus. The HCV genotype consisted of a mixture of Western (genotypes 1, 2, and 3) and Chinese (genotypes 1 and 6) patterns. Quasi species were common (29%). Seven patients (41%) stopped treatment because of complications. Sustained HCV eradication was achieved until the end of treatment or for 24 months in 7 of 17 patients, respectively. A sustained response occurred in 50% of the patients completing treatment and occurred only in patients with genotypes 1, 3, and 6 but not with quasi species. ©2005 The Japanese Society of Hematology.
Persistent Identifierhttp://hdl.handle.net/10722/76476
ISSN
2015 Impact Factor: 1.846
2015 SCImago Journal Rankings: 0.779
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorAu, WYen_HK
dc.contributor.authorLam, CCKen_HK
dc.contributor.authorLiu, CLen_HK
dc.contributor.authorYuen, MFen_HK
dc.date.accessioned2010-09-06T07:21:38Z-
dc.date.available2010-09-06T07:21:38Z-
dc.date.issued2005en_HK
dc.identifier.citationInternational Journal Of Hematology, 2005, v. 82 n. 3, p. 259-261en_HK
dc.identifier.issn0925-5710en_HK
dc.identifier.urihttp://hdl.handle.net/10722/76476-
dc.description.abstractHepatitis C virus (HCV) eradication in hemophilia patients depends on viral and patient factors. We report the treatment results with interferon α (5 megaunits, 3 times per week) and ribavirin (1 g daily) for 1 year in 17 Chinese patients who were negative for the human immunodeficiency virus. The HCV genotype consisted of a mixture of Western (genotypes 1, 2, and 3) and Chinese (genotypes 1 and 6) patterns. Quasi species were common (29%). Seven patients (41%) stopped treatment because of complications. Sustained HCV eradication was achieved until the end of treatment or for 24 months in 7 of 17 patients, respectively. A sustained response occurred in 50% of the patients completing treatment and occurred only in patients with genotypes 1, 3, and 6 but not with quasi species. ©2005 The Japanese Society of Hematology.en_HK
dc.languageengen_HK
dc.publisherSpringer Japan KK.en_HK
dc.relation.ispartofInternational Journal of Hematologyen_HK
dc.subject.meshAdulten_HK
dc.subject.meshAgeden_HK
dc.subject.meshAntiviral Agents - administration & dosageen_HK
dc.subject.meshChinaen_HK
dc.subject.meshFemaleen_HK
dc.subject.meshHIVen_HK
dc.subject.meshHIV Seropositivityen_HK
dc.subject.meshHemophilia A - complications - virologyen_HK
dc.subject.meshHepatitis C - drug therapy - etiologyen_HK
dc.subject.meshHumansen_HK
dc.subject.meshInterferon-alpha - administration & dosageen_HK
dc.subject.meshMaleen_HK
dc.subject.meshMiddle Ageden_HK
dc.subject.meshRibavirin - administration & dosageen_HK
dc.subject.meshTreatment Outcomeen_HK
dc.titleHepatitis C virus infection in adult Chinese hemophilia patients negative for the human immunodeficiency virus: Treatment results with interferon and ribavirinen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0925-5710&volume=82&issue=3&spage=259&epage=261&date=2005&atitle=Hepatitis+C+virus+infection+in+adult+Chinese+hemophilia+patients+negative+for+the+human+immunodeficiency+virus:+treatment+results+with+interferon+and+ribavirinen_HK
dc.identifier.emailYuen, MF:mfyuen@hkucc.hku.hken_HK
dc.identifier.authorityYuen, MF=rp00479en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1532/IJH97.A10417en_HK
dc.identifier.pmid16207601-
dc.identifier.scopuseid_2-s2.0-27644589161en_HK
dc.identifier.hkuros120265en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-27644589161&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume82en_HK
dc.identifier.issue3en_HK
dc.identifier.spage259en_HK
dc.identifier.epage261en_HK
dc.identifier.isiWOS:000232996100016-
dc.publisher.placeJapanen_HK
dc.identifier.scopusauthoridAu, WY=7202383089en_HK
dc.identifier.scopusauthoridLam, CCK=16947291300en_HK
dc.identifier.scopusauthoridLiu, CL=7409789712en_HK
dc.identifier.scopusauthoridYuen, MF=7102031955en_HK

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