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Article: The interleukin-5 messenger RNA expression in a patient with idiopathic hypereosinophilic syndrome

TitleThe interleukin-5 messenger RNA expression in a patient with idiopathic hypereosinophilic syndrome
Authors
KeywordsCorticosteroid
Idiopathic hypereosinophilic syndrome
Interleukin- 5
Therapy
Issue Date1998
PublisherBlackwell Publishing Ltd. The Journal's web site is located at http://www.blackwellpublishing.com/journals/CEA
Citation
Clinical And Experimental Allergy, 1998, v. 28 n. 7, p. 889-892 How to Cite?
AbstractInterleukin-5 has a specific role in various eosinophilic activities. It is the predominant cytokine produces by activated T-lymphocytes isolated from patients with idiopathic hypereosinophilic syndrome. We studied a young patient suffering from idiopathic hypereosinophilic syndrome who presented with Horner's syndrome, peripheral neuropathy and skin ulcers. The IL-5 gene expression by CD4+ T-lymphocytes and the peripheral eosinophil count were raised. The skin ulcers continued to deteriorate despite a swift reduction of the IL-5 gene expression and peripheral eosinophil count following systemic corticosteroid treatment. We suggest that peripheral eosinophilia may not be responsible for the damage in skin lesions and more aggressive treatment may be required.
Persistent Identifierhttp://hdl.handle.net/10722/76459
ISSN
2015 Impact Factor: 5.587
2015 SCImago Journal Rankings: 2.184
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorHo, KKLen_HK
dc.contributor.authorHo, ASSen_HK
dc.contributor.authorLeung, RCCen_HK
dc.contributor.authorLai, CKWen_HK
dc.contributor.authorLai, KNen_HK
dc.date.accessioned2010-09-06T07:21:28Z-
dc.date.available2010-09-06T07:21:28Z-
dc.date.issued1998en_HK
dc.identifier.citationClinical And Experimental Allergy, 1998, v. 28 n. 7, p. 889-892en_HK
dc.identifier.issn0954-7894en_HK
dc.identifier.urihttp://hdl.handle.net/10722/76459-
dc.description.abstractInterleukin-5 has a specific role in various eosinophilic activities. It is the predominant cytokine produces by activated T-lymphocytes isolated from patients with idiopathic hypereosinophilic syndrome. We studied a young patient suffering from idiopathic hypereosinophilic syndrome who presented with Horner's syndrome, peripheral neuropathy and skin ulcers. The IL-5 gene expression by CD4+ T-lymphocytes and the peripheral eosinophil count were raised. The skin ulcers continued to deteriorate despite a swift reduction of the IL-5 gene expression and peripheral eosinophil count following systemic corticosteroid treatment. We suggest that peripheral eosinophilia may not be responsible for the damage in skin lesions and more aggressive treatment may be required.en_HK
dc.languageengen_HK
dc.publisherBlackwell Publishing Ltd. The Journal's web site is located at http://www.blackwellpublishing.com/journals/CEAen_HK
dc.relation.ispartofClinical and Experimental Allergyen_HK
dc.rightsClinical and Experimental Allergy. Copyright © Blackwell Publishing Ltd.en_HK
dc.subjectCorticosteroiden_HK
dc.subjectIdiopathic hypereosinophilic syndromeen_HK
dc.subjectInterleukin- 5en_HK
dc.subjectTherapyen_HK
dc.titleThe interleukin-5 messenger RNA expression in a patient with idiopathic hypereosinophilic syndromeen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0954-7894&volume=28&spage=889&epage=892&date=1998&atitle=The+interleukin-5+messenger+RNA+expression+in+a+patient+with+idiopathic+hypereosinophilic+syndromeen_HK
dc.identifier.emailLai, KN: knlai@hku.hken_HK
dc.identifier.authorityLai, KN=rp00324en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1046/j.1365-2222.1998.00337.xen_HK
dc.identifier.pmid9720824-
dc.identifier.scopuseid_2-s2.0-0031812953en_HK
dc.identifier.hkuros41509en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0031812953&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume28en_HK
dc.identifier.issue7en_HK
dc.identifier.spage889en_HK
dc.identifier.epage892en_HK
dc.identifier.isiWOS:000075104800016-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridHo, KKL=15850509100en_HK
dc.identifier.scopusauthoridHo, ASS=7402675199en_HK
dc.identifier.scopusauthoridLeung, RCC=7101875690en_HK
dc.identifier.scopusauthoridLai, CKW=7403086390en_HK
dc.identifier.scopusauthoridLai, KN=7402135706en_HK

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