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Article: Differential effects of 9-cis, 13-cis and all-trans retinoic acids on the neuronal differentiation of human neuroblastoma cells

TitleDifferential effects of 9-cis, 13-cis and all-trans retinoic acids on the neuronal differentiation of human neuroblastoma cells
Authors
Issue Date2003
PublisherLippincott Williams & Wilkins. The Journal's web site is located at http://www.neuroreport.com
Citation
Neuroreport, 2003, v. 14 n. 15, p. 1935-1939 How to Cite?
AbstractA human neuroblastoma cell line IMR-32 was used as an in vitro model to examine three naturally occurring retinoic acid (RA) isomers, 9-cis (9c), 13-cis (13c) and all-trans (AT) RA, in mediating growth differentiation and neuronal differentiation. All RA isomers inhibited cellular proliferation, with 13c-RA being most effective. Cyclic AMP-responsive-element-binding-protein (CREB) was activated during RA treatment. AT-RA was a better differentiating agent in inducing the highest expression of the neurotrophic factor receptor TrkA. After prolonged RA treatment, the expression of RA receptors (RARs) was comparable for the three isomers, but retinoid X receptors (RXRs) were differentially regulated. These results imply that distinctive molecular pathways might be involved in the in vitro differentiation of neuroblastoma with different RA isomers. © 2003 Lippincott Williams & Wilkins.
Persistent Identifierhttp://hdl.handle.net/10722/76446
ISSN
2015 Impact Factor: 1.343
2015 SCImago Journal Rankings: 0.783
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorChu, PWKen_HK
dc.contributor.authorCheung, WMWen_HK
dc.contributor.authorKwong, YLen_HK
dc.date.accessioned2010-09-06T07:21:19Z-
dc.date.available2010-09-06T07:21:19Z-
dc.date.issued2003en_HK
dc.identifier.citationNeuroreport, 2003, v. 14 n. 15, p. 1935-1939en_HK
dc.identifier.issn0959-4965en_HK
dc.identifier.urihttp://hdl.handle.net/10722/76446-
dc.description.abstractA human neuroblastoma cell line IMR-32 was used as an in vitro model to examine three naturally occurring retinoic acid (RA) isomers, 9-cis (9c), 13-cis (13c) and all-trans (AT) RA, in mediating growth differentiation and neuronal differentiation. All RA isomers inhibited cellular proliferation, with 13c-RA being most effective. Cyclic AMP-responsive-element-binding-protein (CREB) was activated during RA treatment. AT-RA was a better differentiating agent in inducing the highest expression of the neurotrophic factor receptor TrkA. After prolonged RA treatment, the expression of RA receptors (RARs) was comparable for the three isomers, but retinoid X receptors (RXRs) were differentially regulated. These results imply that distinctive molecular pathways might be involved in the in vitro differentiation of neuroblastoma with different RA isomers. © 2003 Lippincott Williams & Wilkins.en_HK
dc.languageengen_HK
dc.publisherLippincott Williams & Wilkins. The Journal's web site is located at http://www.neuroreport.comen_HK
dc.relation.ispartofNeuroReporten_HK
dc.rightsNeuroreport. Copyright © Lippincott Williams & Wilkins.en_HK
dc.subject.meshBiological Markersen_HK
dc.subject.meshBlotting, Westernen_HK
dc.subject.meshBrain Neoplasms - pathologyen_HK
dc.subject.meshCell Differentiation - drug effectsen_HK
dc.subject.meshCell Division - drug effectsen_HK
dc.subject.meshCell Line, Tumoren_HK
dc.subject.meshCyclic AMP Response Element-Binding Protein - metabolismen_HK
dc.subject.meshHumansen_HK
dc.subject.meshNeuroblastoma - pathologyen_HK
dc.subject.meshNeurons - drug effectsen_HK
dc.subject.meshReceptor, trkA - metabolismen_HK
dc.subject.meshReceptors, Retinoic Acid - drug effects - metabolismen_HK
dc.subject.meshRetinoid X Receptorsen_HK
dc.subject.meshSignal Transduction - drug effects - physiologyen_HK
dc.subject.meshStereoisomerismen_HK
dc.subject.meshTranscription Factors - drug effects - metabolismen_HK
dc.subject.meshTransfectionen_HK
dc.subject.meshTretinoin - chemistry - pharmacologyen_HK
dc.subject.meshbeta-Galactosidase - metabolismen_HK
dc.titleDifferential effects of 9-cis, 13-cis and all-trans retinoic acids on the neuronal differentiation of human neuroblastoma cellsen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0959-4965&volume=14&issue=15&spage=1935&epage=1939&date=2003&atitle=Differential+effects+of+9-cis,+13-cis+and+all-trans+retinoic+acids+on+the+neuronal+differentiation+of+human+neuroblastoma+cellsen_HK
dc.identifier.emailKwong, YL:ylkwong@hku.hken_HK
dc.identifier.authorityKwong, YL=rp00358en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1097/00001756-200310270-00011en_HK
dc.identifier.pmid14561924en_HK
dc.identifier.scopuseid_2-s2.0-0642278084en_HK
dc.identifier.hkuros87924en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0642278084&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume14en_HK
dc.identifier.issue15en_HK
dc.identifier.spage1935en_HK
dc.identifier.epage1939en_HK
dc.identifier.isiWOS:000220208500011-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridChu, PWK=7402159518en_HK
dc.identifier.scopusauthoridCheung, WMW=7202743069en_HK
dc.identifier.scopusauthoridKwong, YL=7102818954en_HK

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