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Article: Association of HLA class-II genes and anti-neutrophil cytoplasmic antibodies in Chinese patients with inflammatory bowel disease

TitleAssociation of HLA class-II genes and anti-neutrophil cytoplasmic antibodies in Chinese patients with inflammatory bowel disease
Authors
KeywordsAnti-neutrophil cytoplasmic antibodies
Chinese
Human leucocyte class-II antigens
Inflammatory bowel disease
Issue Date1998
PublisherInforma Healthcare. The Journal's web site is located at http://www.tandf.co.uk/journals/titles/00365521.asp
Citation
Scandinavian Journal Of Gastroenterology, 1998, v. 33 n. 6, p. 623-627 How to Cite?
AbstractBackground: Inflammatory bowel disease is common in the West but rare in China. The genetic factor predisposing to the disease is unclear. Ulcerative colitis (UC) is found to be associated with HLA DR2 alleles in the West. Subgroups of UC patients have been further defined by the presence of anti- neutrophil cytoplasmic antibodies (ANCA). Methods: We attempted to define the HLA class-II genes (DRβ, DQα, DQβ) and their relationship with ANCA in southern Chinese patients with UC. Patients were tested for class-II genes by restriction fragment length polymorphism and polymerase chain reactions. The indirect immunofluorescence test was used to detect ANCA in the sera. Ethnically matched normal controls were used for comparison. Results: In ANCA-positive UC patients (n = 18) there was a strong association with HLA- DQαlc allele (P < 0.0001) when compared with controls (n = 104). This association was not found in ANCA-negative UC patients (n = 10) (P = 0.21). Conclusions: In Chinese UC patients positive ANCA is associated with the HLA- DQα1c allele, which is not the case in Caucasian patients.
Persistent Identifierhttp://hdl.handle.net/10722/76421
ISSN
2015 Impact Factor: 2.199
2015 SCImago Journal Rankings: 0.891
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorLee, YTen_HK
dc.contributor.authorSung, JJYen_HK
dc.contributor.authorPoon, Pen_HK
dc.contributor.authorLai, KNen_HK
dc.contributor.authorLi, PKTen_HK
dc.date.accessioned2010-09-06T07:21:03Z-
dc.date.available2010-09-06T07:21:03Z-
dc.date.issued1998en_HK
dc.identifier.citationScandinavian Journal Of Gastroenterology, 1998, v. 33 n. 6, p. 623-627en_HK
dc.identifier.issn0036-5521en_HK
dc.identifier.urihttp://hdl.handle.net/10722/76421-
dc.description.abstractBackground: Inflammatory bowel disease is common in the West but rare in China. The genetic factor predisposing to the disease is unclear. Ulcerative colitis (UC) is found to be associated with HLA DR2 alleles in the West. Subgroups of UC patients have been further defined by the presence of anti- neutrophil cytoplasmic antibodies (ANCA). Methods: We attempted to define the HLA class-II genes (DRβ, DQα, DQβ) and their relationship with ANCA in southern Chinese patients with UC. Patients were tested for class-II genes by restriction fragment length polymorphism and polymerase chain reactions. The indirect immunofluorescence test was used to detect ANCA in the sera. Ethnically matched normal controls were used for comparison. Results: In ANCA-positive UC patients (n = 18) there was a strong association with HLA- DQαlc allele (P < 0.0001) when compared with controls (n = 104). This association was not found in ANCA-negative UC patients (n = 10) (P = 0.21). Conclusions: In Chinese UC patients positive ANCA is associated with the HLA- DQα1c allele, which is not the case in Caucasian patients.en_HK
dc.languageengen_HK
dc.publisherInforma Healthcare. The Journal's web site is located at http://www.tandf.co.uk/journals/titles/00365521.aspen_HK
dc.relation.ispartofScandinavian Journal of Gastroenterologyen_HK
dc.rightsScandinavian Journal of Gastroenterology. Copyright © Informa Healthcare.en_HK
dc.subjectAnti-neutrophil cytoplasmic antibodiesen_HK
dc.subjectChineseen_HK
dc.subjectHuman leucocyte class-II antigensen_HK
dc.subjectInflammatory bowel diseaseen_HK
dc.titleAssociation of HLA class-II genes and anti-neutrophil cytoplasmic antibodies in Chinese patients with inflammatory bowel diseaseen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0036-5521&volume=33&spage=623&epage=627&date=1998&atitle=Association+of+HLA+class-II+genes+and+anti-neutrophil+cytoplasmic+antibodies+in+Chinese+patients+with+inflammatory+bowel+diseasesen_HK
dc.identifier.emailLai, KN: knlai@hku.hken_HK
dc.identifier.authorityLai, KN=rp00324en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1080/00365529850171909en_HK
dc.identifier.pmid9669635-
dc.identifier.scopuseid_2-s2.0-0031836134en_HK
dc.identifier.hkuros41514en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0031836134&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume33en_HK
dc.identifier.issue6en_HK
dc.identifier.spage623en_HK
dc.identifier.epage627en_HK
dc.identifier.isiWOS:000074341600013-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridLee, YT=35477936800en_HK
dc.identifier.scopusauthoridSung, JJY=35405352400en_HK
dc.identifier.scopusauthoridPoon, P=7101925989en_HK
dc.identifier.scopusauthoridLai, KN=7402135706en_HK
dc.identifier.scopusauthoridLi, PKT=25928016800en_HK

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