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Article: T-cell intravascular lymphomatosis (angiotropic large cell lymphoma): Association with Epstein-Barr viral infection

TitleT-cell intravascular lymphomatosis (angiotropic large cell lymphoma): Association with Epstein-Barr viral infection
Authors
KeywordsEpstein-Barr virus
Intravascular lymphomatosis
T-cell
Issue Date1997
PublisherBlackwell Publishing Ltd. The Journal's web site is located at http://www.blackwellpublishing.com/journals/HIS
Citation
Histopathology, 1997, v. 31 n. 6, p. 563-567 How to Cite?
AbstractAims: Intravascular lymphomatosis (IVL) is a very rare non-Hodgkin's lymphoma characterized by proliferation of lymphoma cells in the vascular lumina without involvement of adjacent parenchymal tissue. IVL is predominantly of B-cell lineage, but occasional cases of T lineage IVL involving almost exclusively the skin have been described. A case of IVL that occurred initially in the epididymis of a patient with an antecedent nasopharyngeal carcinoma was studied to define the clinicopathological features associated with this unique presentation. Methods and results: This lymphoma was studied by standard histological and immunophenotyping methods. The results showed lymphoma cells confined within the blood vessels, which expressed leucocyte common antigen, and T-cell markers CD3 and UCHL-1. The T- cell origin of the IVL prompted investigations for an association with Epstein-Barr virus infection (EBV). Insitu hybridization with digoxigenin- labelled anti-sense RNA probes to EBV encoded RNA (EBER) showed strong signals in the nuclei of virtually all of the lymphoma cells. Conclusions: EBV infection of the malignant cells was demonstrated by in-situ hybridization. This case suggests that T-cell IVL may be another EBV related human neoplasm. This observation will need to be validated by further studies.
Persistent Identifierhttp://hdl.handle.net/10722/76416
ISSN
2015 Impact Factor: 3.425
2015 SCImago Journal Rankings: 1.488
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorAu, WYen_HK
dc.contributor.authorShek, WHen_HK
dc.contributor.authorNicholls, Jen_HK
dc.contributor.authorTse, KMen_HK
dc.contributor.authorTodd, Den_HK
dc.contributor.authorKwong, YLen_HK
dc.date.accessioned2010-09-06T07:21:00Z-
dc.date.available2010-09-06T07:21:00Z-
dc.date.issued1997en_HK
dc.identifier.citationHistopathology, 1997, v. 31 n. 6, p. 563-567en_HK
dc.identifier.issn0309-0167en_HK
dc.identifier.urihttp://hdl.handle.net/10722/76416-
dc.description.abstractAims: Intravascular lymphomatosis (IVL) is a very rare non-Hodgkin's lymphoma characterized by proliferation of lymphoma cells in the vascular lumina without involvement of adjacent parenchymal tissue. IVL is predominantly of B-cell lineage, but occasional cases of T lineage IVL involving almost exclusively the skin have been described. A case of IVL that occurred initially in the epididymis of a patient with an antecedent nasopharyngeal carcinoma was studied to define the clinicopathological features associated with this unique presentation. Methods and results: This lymphoma was studied by standard histological and immunophenotyping methods. The results showed lymphoma cells confined within the blood vessels, which expressed leucocyte common antigen, and T-cell markers CD3 and UCHL-1. The T- cell origin of the IVL prompted investigations for an association with Epstein-Barr virus infection (EBV). Insitu hybridization with digoxigenin- labelled anti-sense RNA probes to EBV encoded RNA (EBER) showed strong signals in the nuclei of virtually all of the lymphoma cells. Conclusions: EBV infection of the malignant cells was demonstrated by in-situ hybridization. This case suggests that T-cell IVL may be another EBV related human neoplasm. This observation will need to be validated by further studies.en_HK
dc.languageengen_HK
dc.publisherBlackwell Publishing Ltd. The Journal's web site is located at http://www.blackwellpublishing.com/journals/HISen_HK
dc.relation.ispartofHistopathologyen_HK
dc.rightsHistopathology. Copyright © Blackwell Publishing Ltd.en_HK
dc.subjectEpstein-Barr virusen_HK
dc.subjectIntravascular lymphomatosisen_HK
dc.subjectT-cellen_HK
dc.subject.meshFatal Outcomeen_HK
dc.subject.meshHerpesviridae Infections - pathologyen_HK
dc.subject.meshHerpesvirus 4, Humanen_HK
dc.subject.meshHumansen_HK
dc.subject.meshLymphoma, Large B-Cell, Diffuse - pathology - virologyen_HK
dc.subject.meshLymphoma, T-Cell - pathology - virologyen_HK
dc.subject.meshMaleen_HK
dc.subject.meshMiddle Ageden_HK
dc.subject.meshTumor Virus Infections - pathologyen_HK
dc.titleT-cell intravascular lymphomatosis (angiotropic large cell lymphoma): Association with Epstein-Barr viral infectionen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0309-0167&volume=31&spage=563&epage=567&date=1997&atitle=T-cell+intravascular+lymphomatosis+(angiotropic+large+cell+lymphoma):+association+with+Epstein-Barr+viral+infectionen_HK
dc.identifier.emailNicholls, J:nicholls@pathology.hku.hken_HK
dc.identifier.emailKwong, YL:ylkwong@hku.hken_HK
dc.identifier.authorityNicholls, J=rp00364en_HK
dc.identifier.authorityKwong, YL=rp00358en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.pmid9447389-
dc.identifier.scopuseid_2-s2.0-0031442275en_HK
dc.identifier.hkuros34025en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0031442275&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume31en_HK
dc.identifier.issue6en_HK
dc.identifier.spage563en_HK
dc.identifier.epage567en_HK
dc.identifier.isiWOS:000071222800010-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridAu, WY=7202383089en_HK
dc.identifier.scopusauthoridShek, WH=6701476327en_HK
dc.identifier.scopusauthoridNicholls, J=7201463077en_HK
dc.identifier.scopusauthoridTse, KM=7102609806en_HK
dc.identifier.scopusauthoridTodd, D=7201388182en_HK
dc.identifier.scopusauthoridKwong, YL=7102818954en_HK

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