File Download

There are no files associated with this item.

  Links for fulltext
     (May Require Subscription)
Supplementary

Article: Association of low-density lipoprotein receptor-related protein 5 (LRP5) promoter SNP with peak bone mineral density in Chinese women

TitleAssociation of low-density lipoprotein receptor-related protein 5 (LRP5) promoter SNP with peak bone mineral density in Chinese women
Authors
KeywordsAssociation study
BMD
Chinese
Genetic association
LRP5
Osteoporosis
SNP
Issue Date2008
PublisherS Karger AG. The Journal's web site is located at http://www.karger.com/HHE
Citation
Human Heredity, 2008, v. 65 n. 4, p. 232-239 How to Cite?
AbstractObjective: Low-density lipoprotein receptor-related protein 5 (LRP5) is important for osteoblast differentiation and mutations of the gene are associated with both low and high bone mass syndromes. Our study aimed to evaluate the importance of LRP5 in the determination of peak bone mass acquisition in Chinese females in the general population. Methods: A total of 286 young southern Chinese females (aged 22-44 years) with low bone mineral density (BMD) (defined by a BMD Z score ≤-1.28 at either the hip or spine) or high BMD (Z score ≥+1) were studied. The LRP5 gene was sequenced for single nucleotide polymorphisms (SNPs) and 4 SNPs were tagged from 8 genotyped SNPs for this study. Results: Single locus allele association tests revealed significant associations of rs682429 and rs686921 with BMD variation (p < 0.05). Omnibus test (likelihood ratio test) revealed overall significant association between LRP5 gene locus and total hip BMD, with rs682429 being most predictive. rs682429 is located in 5′UTR, 2 bases adjacent to a consensus recognition site for the Elk-1 binding element. Conclusion: Common variations of the LRP5 promoter are associated with BMD in young women. These significant associations appear to be driven by rs682429. Functional studies are necessary to elucidate the role of this SNP on the effect of Elk-1 binding element transcriptional activity of LRP5 gene. Copyright © 2007 S. Karger AG.
Persistent Identifierhttp://hdl.handle.net/10722/76375
ISSN
2015 Impact Factor: 1.539
2015 SCImago Journal Rankings: 0.942
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorCheung, CLen_HK
dc.contributor.authorHuang, QYen_HK
dc.contributor.authorChan, Ven_HK
dc.contributor.authorKung, AWCen_HK
dc.date.accessioned2010-09-06T07:20:33Z-
dc.date.available2010-09-06T07:20:33Z-
dc.date.issued2008en_HK
dc.identifier.citationHuman Heredity, 2008, v. 65 n. 4, p. 232-239en_HK
dc.identifier.issn0001-5652en_HK
dc.identifier.urihttp://hdl.handle.net/10722/76375-
dc.description.abstractObjective: Low-density lipoprotein receptor-related protein 5 (LRP5) is important for osteoblast differentiation and mutations of the gene are associated with both low and high bone mass syndromes. Our study aimed to evaluate the importance of LRP5 in the determination of peak bone mass acquisition in Chinese females in the general population. Methods: A total of 286 young southern Chinese females (aged 22-44 years) with low bone mineral density (BMD) (defined by a BMD Z score ≤-1.28 at either the hip or spine) or high BMD (Z score ≥+1) were studied. The LRP5 gene was sequenced for single nucleotide polymorphisms (SNPs) and 4 SNPs were tagged from 8 genotyped SNPs for this study. Results: Single locus allele association tests revealed significant associations of rs682429 and rs686921 with BMD variation (p < 0.05). Omnibus test (likelihood ratio test) revealed overall significant association between LRP5 gene locus and total hip BMD, with rs682429 being most predictive. rs682429 is located in 5′UTR, 2 bases adjacent to a consensus recognition site for the Elk-1 binding element. Conclusion: Common variations of the LRP5 promoter are associated with BMD in young women. These significant associations appear to be driven by rs682429. Functional studies are necessary to elucidate the role of this SNP on the effect of Elk-1 binding element transcriptional activity of LRP5 gene. Copyright © 2007 S. Karger AG.en_HK
dc.languageengen_HK
dc.publisherS Karger AG. The Journal's web site is located at http://www.karger.com/HHEen_HK
dc.relation.ispartofHuman Heredityen_HK
dc.rightsHuman Heredity. Copyright © S Karger AG.en_HK
dc.subjectAssociation studyen_HK
dc.subjectBMDen_HK
dc.subjectChineseen_HK
dc.subjectGenetic associationen_HK
dc.subjectLRP5en_HK
dc.subjectOsteoporosisen_HK
dc.subjectSNPen_HK
dc.subject.meshAdulten_HK
dc.subject.meshAsian Continental Ancestry Group - geneticsen_HK
dc.subject.meshBone Density - geneticsen_HK
dc.subject.meshFemaleen_HK
dc.subject.meshFemur Neck - physiologyen_HK
dc.subject.meshGene Frequencyen_HK
dc.subject.meshGenotypeen_HK
dc.subject.meshHip - physiologyen_HK
dc.subject.meshHumansen_HK
dc.subject.meshLDL-Receptor Related Proteins - geneticsen_HK
dc.subject.meshLinkage Disequilibriumen_HK
dc.subject.meshLow Density Lipoprotein Receptor-Related Protein-5en_HK
dc.subject.meshLumbar Vertebrae - physiologyen_HK
dc.subject.meshPolymorphism, Single Nucleotideen_HK
dc.subject.meshPromoter Regions, Genetic - geneticsen_HK
dc.subject.meshSequence Analysis, DNAen_HK
dc.titleAssociation of low-density lipoprotein receptor-related protein 5 (LRP5) promoter SNP with peak bone mineral density in Chinese womenen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0001-5652&volume=65&issue=4&spage=232&epage=239&date=2007&atitle=Association+of+low-density+lipoprotein+receptor-related+protein+5+(LRP5)+promoter+SNP+with+peak+bone+mineral+density+in+Chinese+women.en_HK
dc.identifier.emailCheung, CL: lung1212@hku.hken_HK
dc.identifier.emailHuang, QY: qyhuang@hotmail.comen_HK
dc.identifier.emailChan, V: vnychana@hkucc.hku.hken_HK
dc.identifier.emailKung, AWC: awckung@hku.hken_HK
dc.identifier.authorityCheung, CL=rp01749en_HK
dc.identifier.authorityHuang, QY=rp00521en_HK
dc.identifier.authorityChan, V=rp00320en_HK
dc.identifier.authorityKung, AWC=rp00368en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1159/000112370en_HK
dc.identifier.pmid18073493-
dc.identifier.scopuseid_2-s2.0-38649109162en_HK
dc.identifier.hkuros141387en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-38649109162&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume65en_HK
dc.identifier.issue4en_HK
dc.identifier.spage232en_HK
dc.identifier.epage239en_HK
dc.identifier.isiWOS:000252877500006-
dc.publisher.placeSwitzerlanden_HK
dc.identifier.scopusauthoridCheung, CL=14520953400en_HK
dc.identifier.scopusauthoridHuang, QY=7403630787en_HK
dc.identifier.scopusauthoridChan, V=7202654865en_HK
dc.identifier.scopusauthoridKung, AWC=7102322339en_HK

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats