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Article: Analysis of clonality in Kimura's disease

TitleAnalysis of clonality in Kimura's disease
Authors
Issue Date2002
PublisherLippincott Williams & Wilkins. The Journal's web site is located at http://www.ajsp.com
Citation
American Journal Of Surgical Pathology, 2002, v. 26 n. 8, p. 1083-1086 How to Cite?
AbstractKimura's disease is a chronic inflammatory disorder of unknown etiology. A 62-year-old man presented with asymptomatic cervical lymphadenopathy associated with eosinophilia and increased serum immunoglobulin E. Excision biopsy showed Kimura's disease. Three years later another groin lymph node appeared and showed similar pathologic features. Polymerase chain reaction for Ig heavy chain and T-cell receptor (TCR) genes on DNA extracted from the cervical lymph node showed smear patterns. However, polymerase chain reaction for TCR8 gene showed a clonal rearrangement. Sequencing showed a complete VDJ rearrangement (Vδ1-N-Dδ2-N-Jδ), confirming the presence of a clonal T cell population. The same clonal TCRδ rearrangement was amplified by polymerase chain reaction from the groin lymph node biopsied 3 years later. These results showed that the primary and recurrent lesions were biologically related. Furthermore, the presence of identical T cell clones in different sites and at different times suggested that a clonal T cell population might have contributed to the pathogenesis in this case of Kimura's disease.
Persistent Identifierhttp://hdl.handle.net/10722/76344
ISSN
2015 Impact Factor: 4.951
2015 SCImago Journal Rankings: 2.393
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorChim, CSen_HK
dc.contributor.authorFung, Aen_HK
dc.contributor.authorShek, TWHen_HK
dc.contributor.authorLiang, Ren_HK
dc.contributor.authorHo, WKen_HK
dc.contributor.authorKwong, YLen_HK
dc.date.accessioned2010-09-06T07:20:14Z-
dc.date.available2010-09-06T07:20:14Z-
dc.date.issued2002en_HK
dc.identifier.citationAmerican Journal Of Surgical Pathology, 2002, v. 26 n. 8, p. 1083-1086en_HK
dc.identifier.issn0147-5185en_HK
dc.identifier.urihttp://hdl.handle.net/10722/76344-
dc.description.abstractKimura's disease is a chronic inflammatory disorder of unknown etiology. A 62-year-old man presented with asymptomatic cervical lymphadenopathy associated with eosinophilia and increased serum immunoglobulin E. Excision biopsy showed Kimura's disease. Three years later another groin lymph node appeared and showed similar pathologic features. Polymerase chain reaction for Ig heavy chain and T-cell receptor (TCR) genes on DNA extracted from the cervical lymph node showed smear patterns. However, polymerase chain reaction for TCR8 gene showed a clonal rearrangement. Sequencing showed a complete VDJ rearrangement (Vδ1-N-Dδ2-N-Jδ), confirming the presence of a clonal T cell population. The same clonal TCRδ rearrangement was amplified by polymerase chain reaction from the groin lymph node biopsied 3 years later. These results showed that the primary and recurrent lesions were biologically related. Furthermore, the presence of identical T cell clones in different sites and at different times suggested that a clonal T cell population might have contributed to the pathogenesis in this case of Kimura's disease.en_HK
dc.languageengen_HK
dc.publisherLippincott Williams & Wilkins. The Journal's web site is located at http://www.ajsp.comen_HK
dc.relation.ispartofAmerican Journal of Surgical Pathologyen_HK
dc.rightsAmerican Journal of Surgical Pathology. Copyright © Lippincott Williams & Wilkins.en_HK
dc.subject.meshAngiolymphoid Hyperplasia with Eosinophilia - genetics - pathologyen_HK
dc.subject.meshClone Cellsen_HK
dc.subject.meshGenes, T-Cell Receptor - geneticsen_HK
dc.subject.meshHumansen_HK
dc.subject.meshMaleen_HK
dc.subject.meshMiddle Ageden_HK
dc.subject.meshPolymerase Chain Reactionen_HK
dc.subject.meshRecurrenceen_HK
dc.titleAnalysis of clonality in Kimura's diseaseen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0147-5185&volume=26&issue=8&spage=1083&epage=1086&date=2002&atitle=Analysis+of+clonality+in+Kimura%27s+diseaseen_HK
dc.identifier.emailChim, CS:jcschim@hku.hken_HK
dc.identifier.emailLiang, R:rliang@hku.hken_HK
dc.identifier.emailKwong, YL:ylkwong@hku.hken_HK
dc.identifier.authorityChim, CS=rp00408en_HK
dc.identifier.authorityLiang, R=rp00345en_HK
dc.identifier.authorityKwong, YL=rp00358en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1097/00000478-200208000-00016en_HK
dc.identifier.pmid12170098en_HK
dc.identifier.scopuseid_2-s2.0-0036322355en_HK
dc.identifier.hkuros78945en_HK
dc.identifier.hkuros77947-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0036322355&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume26en_HK
dc.identifier.issue8en_HK
dc.identifier.spage1083en_HK
dc.identifier.epage1086en_HK
dc.identifier.isiWOS:000177167100016-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridChim, CS=7004597253en_HK
dc.identifier.scopusauthoridFung, A=7101926728en_HK
dc.identifier.scopusauthoridShek, TWH=7005479861en_HK
dc.identifier.scopusauthoridLiang, R=26643224900en_HK
dc.identifier.scopusauthoridHo, WK=7402968844en_HK
dc.identifier.scopusauthoridKwong, YL=7102818954en_HK

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