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Article: Granulocytic sarcoma of megakaryoblastic differentiation complicating chronic idiopathic myelofibrosis

TitleGranulocytic sarcoma of megakaryoblastic differentiation complicating chronic idiopathic myelofibrosis
Authors
Chan, ACLKwong, YLLam, CCK
Keywordsblastic transformation
chronic idiopathic myelofibrosis
granulocytic sarcoma
megakaryoblastic leukemia
partial trisomy 1
signet ring cell
Issue Date1996
PublisherWB Saunders Co. The Journal's web site is located at http://www.elsevier.com/locate/humpath
Citation
Human Pathology, 1996, v. 27 n. 4, p. 417-420 How to Cite?
DOI: http://dx.doi.org/10.1016/S0046-8177(96)90116-1
AbstractWe report the development of soft tissue granulocytic sarcoma with megakaryoblastic differentiation in a patient with chronic idiopathic myelofibrosis, which has hitherto been undescribed. Although an artifactual signet ring appearance of the blasts was found in the formalin-fixed tissue and caused diagnostic problems, the histological appearance on B-5 fixed material and immunophenotyping confirmed the diagnosis. Cytogenetic analysis showed 47,XY,+der(1)del(1) (?p13) at initial presentation and 47,XY,del(1)(?p13),+der(1)del(1) (?p13) at the time of soft tissue blastic transformation, indicating that partial trisomy 1 might be of pathogenetic significance.
Persistent Identifierhttp://hdl.handle.net/10722/76320
ISSN
0046-8177
2023 Impact Factor: 2.7
2023 SCImago Journal Rankings: 0.936
ISI Accession Number ID
WOS:A1996UF10500016
References
References in Scopus

 

DC FieldValueLanguage
dc.contributor.authorChan, ACLen_HK
dc.contributor.authorKwong, YLen_HK
dc.contributor.authorLam, CCKen_HK
dc.date.accessioned2010-09-06T07:19:59Z-
dc.date.available2010-09-06T07:19:59Z-
dc.date.issued1996en_HK
dc.identifier.citationHuman Pathology, 1996, v. 27 n. 4, p. 417-420en_HK
dc.identifier.issn0046-8177en_HK
dc.identifier.urihttp://hdl.handle.net/10722/76320-
dc.description.abstractWe report the development of soft tissue granulocytic sarcoma with megakaryoblastic differentiation in a patient with chronic idiopathic myelofibrosis, which has hitherto been undescribed. Although an artifactual signet ring appearance of the blasts was found in the formalin-fixed tissue and caused diagnostic problems, the histological appearance on B-5 fixed material and immunophenotyping confirmed the diagnosis. Cytogenetic analysis showed 47,XY,+der(1)del(1) (?p13) at initial presentation and 47,XY,del(1)(?p13),+der(1)del(1) (?p13) at the time of soft tissue blastic transformation, indicating that partial trisomy 1 might be of pathogenetic significance.en_HK
dc.languageengen_HK
dc.publisherWB Saunders Co. The Journal's web site is located at http://www.elsevier.com/locate/humpathen_HK
dc.relation.ispartofHuman Pathologyen_HK
dc.subjectblastic transformation-
dc.subjectchronic idiopathic myelofibrosis-
dc.subjectgranulocytic sarcoma-
dc.subjectmegakaryoblastic leukemia-
dc.subjectpartial trisomy 1-
dc.subjectsignet ring cell-
dc.subject.meshAdipose Tissue - pathologyen_HK
dc.subject.meshCarcinoma, Signet Ring Cell - pathologyen_HK
dc.subject.meshHumansen_HK
dc.subject.meshImmunohistochemistryen_HK
dc.subject.meshKaryotypingen_HK
dc.subject.meshLeukemia, Megakaryoblastic, Acute - complications - pathologyen_HK
dc.subject.meshLeukemia, Myeloid - complications - pathologyen_HK
dc.subject.meshMaleen_HK
dc.subject.meshMegakaryocytes - pathologyen_HK
dc.subject.meshMiddle Ageden_HK
dc.subject.meshPrimary Myelofibrosis - complications - pathologyen_HK
dc.titleGranulocytic sarcoma of megakaryoblastic differentiation complicating chronic idiopathic myelofibrosisen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0046-8177&volume=27&spage=417&epage=420&date=1996&atitle=Granulocytic+sarcoma+of+megakaryoblastic+differentiation+complicating+chronic+idiopathic+myelofibrosisen_HK
dc.identifier.emailKwong, YL:ylkwong@hku.hken_HK
dc.identifier.authorityKwong, YL=rp00358en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/S0046-8177(96)90116-1en_HK
dc.identifier.pmid8617486-
dc.identifier.scopuseid_2-s2.0-0029977597en_HK
dc.identifier.hkuros13449en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0029977597&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume27en_HK
dc.identifier.issue4en_HK
dc.identifier.spage417en_HK
dc.identifier.epage420en_HK
dc.identifier.isiWOS:A1996UF10500016-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridChan, ACL=16047349300en_HK
dc.identifier.scopusauthoridKwong, YL=7102818954en_HK
dc.identifier.scopusauthoridLam, CCK=16947291300en_HK
dc.identifier.issnl0046-8177-

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