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Article: Granulocytic sarcoma of megakaryoblastic differentiation complicating chronic idiopathic myelofibrosis

TitleGranulocytic sarcoma of megakaryoblastic differentiation complicating chronic idiopathic myelofibrosis
Authors
Keywordsblastic transformation
chronic idiopathic myelofibrosis
granulocytic sarcoma
megakaryoblastic leukemia
partial trisomy 1
signet ring cell
Issue Date1996
PublisherWB Saunders Co. The Journal's web site is located at http://www.elsevier.com/locate/humpath
Citation
Human Pathology, 1996, v. 27 n. 4, p. 417-420 How to Cite?
AbstractWe report the development of soft tissue granulocytic sarcoma with megakaryoblastic differentiation in a patient with chronic idiopathic myelofibrosis, which has hitherto been undescribed. Although an artifactual signet ring appearance of the blasts was found in the formalin-fixed tissue and caused diagnostic problems, the histological appearance on B-5 fixed material and immunophenotyping confirmed the diagnosis. Cytogenetic analysis showed 47,XY,+der(1)del(1) (?p13) at initial presentation and 47,XY,del(1)(?p13),+der(1)del(1) (?p13) at the time of soft tissue blastic transformation, indicating that partial trisomy 1 might be of pathogenetic significance.
Persistent Identifierhttp://hdl.handle.net/10722/76320
ISSN
2021 Impact Factor: 3.526
2020 SCImago Journal Rankings: 1.213
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorChan, ACLen_HK
dc.contributor.authorKwong, YLen_HK
dc.contributor.authorLam, CCKen_HK
dc.date.accessioned2010-09-06T07:19:59Z-
dc.date.available2010-09-06T07:19:59Z-
dc.date.issued1996en_HK
dc.identifier.citationHuman Pathology, 1996, v. 27 n. 4, p. 417-420en_HK
dc.identifier.issn0046-8177en_HK
dc.identifier.urihttp://hdl.handle.net/10722/76320-
dc.description.abstractWe report the development of soft tissue granulocytic sarcoma with megakaryoblastic differentiation in a patient with chronic idiopathic myelofibrosis, which has hitherto been undescribed. Although an artifactual signet ring appearance of the blasts was found in the formalin-fixed tissue and caused diagnostic problems, the histological appearance on B-5 fixed material and immunophenotyping confirmed the diagnosis. Cytogenetic analysis showed 47,XY,+der(1)del(1) (?p13) at initial presentation and 47,XY,del(1)(?p13),+der(1)del(1) (?p13) at the time of soft tissue blastic transformation, indicating that partial trisomy 1 might be of pathogenetic significance.en_HK
dc.languageengen_HK
dc.publisherWB Saunders Co. The Journal's web site is located at http://www.elsevier.com/locate/humpathen_HK
dc.relation.ispartofHuman Pathologyen_HK
dc.subjectblastic transformation-
dc.subjectchronic idiopathic myelofibrosis-
dc.subjectgranulocytic sarcoma-
dc.subjectmegakaryoblastic leukemia-
dc.subjectpartial trisomy 1-
dc.subjectsignet ring cell-
dc.subject.meshAdipose Tissue - pathologyen_HK
dc.subject.meshCarcinoma, Signet Ring Cell - pathologyen_HK
dc.subject.meshHumansen_HK
dc.subject.meshImmunohistochemistryen_HK
dc.subject.meshKaryotypingen_HK
dc.subject.meshLeukemia, Megakaryoblastic, Acute - complications - pathologyen_HK
dc.subject.meshLeukemia, Myeloid - complications - pathologyen_HK
dc.subject.meshMaleen_HK
dc.subject.meshMegakaryocytes - pathologyen_HK
dc.subject.meshMiddle Ageden_HK
dc.subject.meshPrimary Myelofibrosis - complications - pathologyen_HK
dc.titleGranulocytic sarcoma of megakaryoblastic differentiation complicating chronic idiopathic myelofibrosisen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0046-8177&volume=27&spage=417&epage=420&date=1996&atitle=Granulocytic+sarcoma+of+megakaryoblastic+differentiation+complicating+chronic+idiopathic+myelofibrosisen_HK
dc.identifier.emailKwong, YL:ylkwong@hku.hken_HK
dc.identifier.authorityKwong, YL=rp00358en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/S0046-8177(96)90116-1en_HK
dc.identifier.pmid8617486-
dc.identifier.scopuseid_2-s2.0-0029977597en_HK
dc.identifier.hkuros13449en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0029977597&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume27en_HK
dc.identifier.issue4en_HK
dc.identifier.spage417en_HK
dc.identifier.epage420en_HK
dc.identifier.isiWOS:A1996UF10500016-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridChan, ACL=16047349300en_HK
dc.identifier.scopusauthoridKwong, YL=7102818954en_HK
dc.identifier.scopusauthoridLam, CCK=16947291300en_HK
dc.identifier.issnl0046-8177-

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