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Article: Aspirin induced apoptosis in gastric cancer cells

TitleAspirin induced apoptosis in gastric cancer cells
Authors
Wong, BCYZhu, GHLam, SK
KeywordsApoptosis
Aspirin
Cyclooxygenase
Gastric cancer
Issue Date1999
PublisherElsevier France, Editions Scientifiques et Medicales. The Journal's web site is located at http://www.elsevier.com/locate/biopha
Citation
Biomedicine And Pharmacotherapy, 1999, v. 53 n. 7, p. 315-318 How to Cite?
DOI: http://dx.doi.org/10.1016/S0753-3322(00)88503-0
AbstractAspirin has been well known for its anti-pyretic and anti-inflammatory action over the past century. Its main action in the gastro-intestinal tract has always been associated with erosion and ulceration. However in recent years, there has been evidence suggesting that aspirin and the more potent non-steroidal anti-inflammatory drugs (NSAIDs), could reduce the risk of gastric and colon cancer. One of the possible mechanisms in chemo-prevention is the ability to induce apoptosis in epithelial cells of the gastro- intestinal origin. This article introduces the role of apoptosis in the body and the gastro-intestinal tract. Evidence on the chemo-preventive role of aspirin and NSAIDs are listed, and the mechanisms of action discussed.
Persistent Identifierhttp://hdl.handle.net/10722/76316
ISSN
0753-3322
2023 Impact Factor: 6.9
2023 SCImago Journal Rankings: 1.493
ISI Accession Number ID
WOS:000082516300006
References
References in Scopus

 

DC FieldValueLanguage
dc.contributor.authorWong, BCYen_HK
dc.contributor.authorZhu, GHen_HK
dc.contributor.authorLam, SKen_HK
dc.date.accessioned2010-09-06T07:19:56Z-
dc.date.available2010-09-06T07:19:56Z-
dc.date.issued1999en_HK
dc.identifier.citationBiomedicine And Pharmacotherapy, 1999, v. 53 n. 7, p. 315-318en_HK
dc.identifier.issn0753-3322en_HK
dc.identifier.urihttp://hdl.handle.net/10722/76316-
dc.description.abstractAspirin has been well known for its anti-pyretic and anti-inflammatory action over the past century. Its main action in the gastro-intestinal tract has always been associated with erosion and ulceration. However in recent years, there has been evidence suggesting that aspirin and the more potent non-steroidal anti-inflammatory drugs (NSAIDs), could reduce the risk of gastric and colon cancer. One of the possible mechanisms in chemo-prevention is the ability to induce apoptosis in epithelial cells of the gastro- intestinal origin. This article introduces the role of apoptosis in the body and the gastro-intestinal tract. Evidence on the chemo-preventive role of aspirin and NSAIDs are listed, and the mechanisms of action discussed.en_HK
dc.languageengen_HK
dc.publisherElsevier France, Editions Scientifiques et Medicales. The Journal's web site is located at http://www.elsevier.com/locate/biophaen_HK
dc.relation.ispartofBiomedicine and Pharmacotherapyen_HK
dc.rightsBiomedicine & Pharmacotherapy. Copyright © Elsevier France, Editions Scientifiques et Medicales.en_HK
dc.subjectApoptosis-
dc.subjectAspirin-
dc.subjectCyclooxygenase-
dc.subjectGastric cancer-
dc.subject.meshAnti-Inflammatory Agents, Non-Steroidal - adverse effects - therapeutic useen_HK
dc.subject.meshApoptosis - drug effectsen_HK
dc.subject.meshAspirin - adverse effects - pharmacology - therapeutic useen_HK
dc.subject.meshCyclooxygenase 1en_HK
dc.subject.meshCyclooxygenase 2en_HK
dc.subject.meshHumansen_HK
dc.subject.meshIsoenzymes - metabolismen_HK
dc.subject.meshMembrane Proteinsen_HK
dc.subject.meshProstaglandin-Endoperoxide Synthases - metabolismen_HK
dc.subject.meshStomach Neoplasms - prevention & controlen_HK
dc.titleAspirin induced apoptosis in gastric cancer cellsen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0753-3322&volume=53&spage=315&epage=8&date=1999&atitle=Aspirin+induced+apoptosis+in+gastric+cancer+cellsen_HK
dc.identifier.emailWong, BCY:bcywong@hku.hken_HK
dc.identifier.authorityWong, BCY=rp00429en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/S0753-3322(00)88503-0en_HK
dc.identifier.pmid10472431-
dc.identifier.scopuseid_2-s2.0-0033178151en_HK
dc.identifier.hkuros50514en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0033178151&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume53en_HK
dc.identifier.issue7en_HK
dc.identifier.spage315en_HK
dc.identifier.epage318en_HK
dc.identifier.isiWOS:000082516300006-
dc.publisher.placeFranceen_HK
dc.identifier.scopusauthoridWong, BCY=7402023340en_HK
dc.identifier.scopusauthoridZhu, GH=7402633170en_HK
dc.identifier.scopusauthoridLam, SK=7402279473en_HK
dc.identifier.issnl0753-3322-

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