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Article: Distribution of distinct vacA, cagA and iceA alleles in Helicobacter pylori in Hong Kong

TitleDistribution of distinct vacA, cagA and iceA alleles in Helicobacter pylori in Hong Kong
Authors
Issue Date2001
PublisherBlackwell Publishing Ltd. The Journal's web site is located at http://www.blackwellpublishing.com/journals/HEL
Citation
Helicobacter, 2001, v. 6 n. 4, p. 317-324 How to Cite?
AbstractBackground. There is a substantial genetic heterogeneity among Helicobacter pylori strains, and certain genotypes have been suggested to be associated with the virulence of this pathogen. The aim of this study was to investigate the distribution of H. pylori vacA, cagA and iceA genotypes and their association with duodenal ulcer disease in Hong Kong. Materials and Methods. Gastric biopsies of 72 H. pylori infected patients were analyzed by specific polymerase chain reactions. Results. Of the 72 cases, 69 (95.8%) had vacA signal sequence s1c strains, and three (4.2%) had s1a strains. vacA middle region sequences, m1 and m2, were detected in 23 (31.9%) and 46 (63.9%), respectively. Six (8.3%) cases contained multiple vacA subtypes. vacA s2 allele was only observed in three (4.3 %) cases, which were also infected with s1c subtype.cagA was present in 64 (88.9%) of 72 patients, and iceA1 subtype was detected in 46 (63.9%) cases. Neither cagA nor vacA and iceA were associated with duodenal ulcer disease. Conclusion. The distribution of vacA, cagA and iceA icea alleles in H. pylori strains in Hong Kong is similar to that in east Asia. There is a difference in the distribution of genotypes between strains in Hong Kong and those in mainland China, although strains in the two regions exhibit a very close relation. The association of these virulence genes and duodenal ulcer disease needs reappraisal, particularly under geographic considerations.
Persistent Identifierhttp://hdl.handle.net/10722/76309
ISSN
2015 Impact Factor: 3.92
2015 SCImago Journal Rankings: 1.131
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorWong, BCYen_HK
dc.contributor.authorYin, Yen_HK
dc.contributor.authorBerg, DEen_HK
dc.contributor.authorXia, HHNen_HK
dc.contributor.authorZhang, JZen_HK
dc.contributor.authorWang, WHen_HK
dc.contributor.authorWong, WMen_HK
dc.contributor.authorHuang, XRen_HK
dc.contributor.authorTang, VSYen_HK
dc.contributor.authorLam, SKen_HK
dc.date.accessioned2010-09-06T07:19:52Z-
dc.date.available2010-09-06T07:19:52Z-
dc.date.issued2001en_HK
dc.identifier.citationHelicobacter, 2001, v. 6 n. 4, p. 317-324en_HK
dc.identifier.issn1083-4389en_HK
dc.identifier.urihttp://hdl.handle.net/10722/76309-
dc.description.abstractBackground. There is a substantial genetic heterogeneity among Helicobacter pylori strains, and certain genotypes have been suggested to be associated with the virulence of this pathogen. The aim of this study was to investigate the distribution of H. pylori vacA, cagA and iceA genotypes and their association with duodenal ulcer disease in Hong Kong. Materials and Methods. Gastric biopsies of 72 H. pylori infected patients were analyzed by specific polymerase chain reactions. Results. Of the 72 cases, 69 (95.8%) had vacA signal sequence s1c strains, and three (4.2%) had s1a strains. vacA middle region sequences, m1 and m2, were detected in 23 (31.9%) and 46 (63.9%), respectively. Six (8.3%) cases contained multiple vacA subtypes. vacA s2 allele was only observed in three (4.3 %) cases, which were also infected with s1c subtype.cagA was present in 64 (88.9%) of 72 patients, and iceA1 subtype was detected in 46 (63.9%) cases. Neither cagA nor vacA and iceA were associated with duodenal ulcer disease. Conclusion. The distribution of vacA, cagA and iceA icea alleles in H. pylori strains in Hong Kong is similar to that in east Asia. There is a difference in the distribution of genotypes between strains in Hong Kong and those in mainland China, although strains in the two regions exhibit a very close relation. The association of these virulence genes and duodenal ulcer disease needs reappraisal, particularly under geographic considerations.en_HK
dc.languageengen_HK
dc.publisherBlackwell Publishing Ltd. The Journal's web site is located at http://www.blackwellpublishing.com/journals/HELen_HK
dc.relation.ispartofHelicobacteren_HK
dc.subject.meshAdolescenten_HK
dc.subject.meshAdulten_HK
dc.subject.meshAllelesen_HK
dc.subject.meshAntigens, Bacterialen_HK
dc.subject.meshBacterial Outer Membrane Proteins - geneticsen_HK
dc.subject.meshBacterial Proteins - genetics - metabolismen_HK
dc.subject.meshDuodenal Ulcer - microbiologyen_HK
dc.subject.meshFemaleen_HK
dc.subject.meshGenotypeen_HK
dc.subject.meshHelicobacter Infections - microbiologyen_HK
dc.subject.meshHelicobacter pylori - genetics - pathogenicityen_HK
dc.subject.meshHong Kongen_HK
dc.subject.meshHumansen_HK
dc.subject.meshMaleen_HK
dc.subject.meshMiddle Ageden_HK
dc.subject.meshVirulence - geneticsen_HK
dc.titleDistribution of distinct vacA, cagA and iceA alleles in Helicobacter pylori in Hong Kongen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1083-4389&volume=6&issue=4&spage=317&epage=324&date=2001&atitle=Distribution+of+distinct+vacA,+cagA+and+iceA+alleles+in+Helicobacter+pylori+in+Hong+Kongen_HK
dc.identifier.emailWong, BCY:bcywong@hku.hken_HK
dc.identifier.authorityWong, BCY=rp00429en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1046/j.1523-5378.2001.00040.xen_HK
dc.identifier.pmid11843964-
dc.identifier.scopuseid_2-s2.0-0035660357en_HK
dc.identifier.hkuros72109en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0035660357&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume6en_HK
dc.identifier.issue4en_HK
dc.identifier.spage317en_HK
dc.identifier.epage324en_HK
dc.identifier.isiWOS:000172806800008-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridWong, BCY=7402023340en_HK
dc.identifier.scopusauthoridYin, Y=36847525300en_HK
dc.identifier.scopusauthoridBerg, DE=7202401139en_HK
dc.identifier.scopusauthoridXia, HHN=21036652100en_HK
dc.identifier.scopusauthoridZhang, JZ=9939370800en_HK
dc.identifier.scopusauthoridWang, WH=23390847100en_HK
dc.identifier.scopusauthoridWong, WM=7403972413en_HK
dc.identifier.scopusauthoridHuang, XR=7410248090en_HK
dc.identifier.scopusauthoridTang, VSY=6701711948en_HK
dc.identifier.scopusauthoridLam, SK=7402279473en_HK

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