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Article: Use of single dose low-molecular-weight heparin in long hemodialysis

TitleUse of single dose low-molecular-weight heparin in long hemodialysis
Authors
KeywordsAnti-factor Xa
Dosage
Hemodialysis
Low-molecular-weight heparin
Issue Date1998
PublisherWichtig Editore srl. The Journal's web site is located at http://www.artificial-organs.com
Citation
International Journal Of Artificial Organs, 1998, v. 21 n. 4, p. 196-200 How to Cite?
AbstractLow-molecular-weight (LMW) heparin has recently been used for anti- coagulation in maintenance hemodialysis. The LMW heparin was administered as a single bolus in hemodialysis that usually lasted for four hours or less. The regimen for administering LMW heparin in hemodialysis of longer duration (5 hours or more) is not well documented and manufacturers recommend a supplementary dose equivalent to one-quarter of the initial close to be given at 4 hours after the commencement of hemodialysis. In this study, we explored whether administering a single dose of LMW heparin is feasible in hemodialysis of longer duration. Maintenance five-hour hemodialysis sessions were performed in nine uremic patients with two different heparin regimens: single dose of LMW heparin (nadroparin) 12,500 ICU AXa at the beginning of dialysis or a priming dose of nadroparin 10,000 ICU AXa at the beginning of dialysis followed by a supplementary dose of nadroparin 2,500 ICU AXa at the beginning of the fifth hour of dialysis. Clots in the airtraps or clotting of the dialyser were not observed in hemodialysis with the single dose heparin regimen. The anti-Xa activities at different time intervals during dialysis were above the therapeutic range of 0.5 U/ml except towards the end of the hemodialysis treatment. There was no difference between anti-Xa activities determined in dialysis sessions using two different regimens of LMW heparin at any individual time interval. The anti-thrombotic effect determined by the area under the time response curve for anti-Xa activity was comparable in the two LMW heparin regimens. Hence, our findings suggest a single bolus dose of LMW heparin (nadroparin) at 12,500 ICU AXa provides adequate, safe, and effective anti-coagulation for five-hour hemodialysis. This practice is convenient and avoids the necessity of administering a double dose of LMW heparin.
Persistent Identifierhttp://hdl.handle.net/10722/76300
ISSN
2015 Impact Factor: 1.005
2015 SCImago Journal Rankings: 0.585
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorLai, KNen_HK
dc.contributor.authorHo, Ken_HK
dc.contributor.authorLi, Men_HK
dc.contributor.authorSzeto, CCen_HK
dc.date.accessioned2010-09-06T07:19:46Z-
dc.date.available2010-09-06T07:19:46Z-
dc.date.issued1998en_HK
dc.identifier.citationInternational Journal Of Artificial Organs, 1998, v. 21 n. 4, p. 196-200en_HK
dc.identifier.issn0391-3988en_HK
dc.identifier.urihttp://hdl.handle.net/10722/76300-
dc.description.abstractLow-molecular-weight (LMW) heparin has recently been used for anti- coagulation in maintenance hemodialysis. The LMW heparin was administered as a single bolus in hemodialysis that usually lasted for four hours or less. The regimen for administering LMW heparin in hemodialysis of longer duration (5 hours or more) is not well documented and manufacturers recommend a supplementary dose equivalent to one-quarter of the initial close to be given at 4 hours after the commencement of hemodialysis. In this study, we explored whether administering a single dose of LMW heparin is feasible in hemodialysis of longer duration. Maintenance five-hour hemodialysis sessions were performed in nine uremic patients with two different heparin regimens: single dose of LMW heparin (nadroparin) 12,500 ICU AXa at the beginning of dialysis or a priming dose of nadroparin 10,000 ICU AXa at the beginning of dialysis followed by a supplementary dose of nadroparin 2,500 ICU AXa at the beginning of the fifth hour of dialysis. Clots in the airtraps or clotting of the dialyser were not observed in hemodialysis with the single dose heparin regimen. The anti-Xa activities at different time intervals during dialysis were above the therapeutic range of 0.5 U/ml except towards the end of the hemodialysis treatment. There was no difference between anti-Xa activities determined in dialysis sessions using two different regimens of LMW heparin at any individual time interval. The anti-thrombotic effect determined by the area under the time response curve for anti-Xa activity was comparable in the two LMW heparin regimens. Hence, our findings suggest a single bolus dose of LMW heparin (nadroparin) at 12,500 ICU AXa provides adequate, safe, and effective anti-coagulation for five-hour hemodialysis. This practice is convenient and avoids the necessity of administering a double dose of LMW heparin.en_HK
dc.languageengen_HK
dc.publisherWichtig Editore srl. The Journal's web site is located at http://www.artificial-organs.comen_HK
dc.relation.ispartofInternational Journal of Artificial Organsen_HK
dc.subjectAnti-factor Xaen_HK
dc.subjectDosageen_HK
dc.subjectHemodialysisen_HK
dc.subjectLow-molecular-weight heparinen_HK
dc.titleUse of single dose low-molecular-weight heparin in long hemodialysisen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0391-3988&volume=21&spage=192&epage=195&date=1998&atitle=Use+of+single-dose+low-molecular+weight+heparin+in+long+hemodialysisen_HK
dc.identifier.emailLai, KN: knlai@hku.hken_HK
dc.identifier.authorityLai, KN=rp00324en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.pmid9649059-
dc.identifier.scopuseid_2-s2.0-0031841562en_HK
dc.identifier.hkuros41507en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0031841562&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume21en_HK
dc.identifier.issue4en_HK
dc.identifier.spage196en_HK
dc.identifier.epage200en_HK
dc.identifier.isiWOS:000074169300004-
dc.publisher.placeItalyen_HK
dc.identifier.scopusauthoridLai, KN=7402135706en_HK
dc.identifier.scopusauthoridHo, K=15850509100en_HK
dc.identifier.scopusauthoridLi, M=8347419900en_HK
dc.identifier.scopusauthoridSzeto, CC=35495407200en_HK

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