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Article: No evidence of automatic atrial overdrive pacing efficacy on reduction of paroxysmal atrial fibrillation

TitleNo evidence of automatic atrial overdrive pacing efficacy on reduction of paroxysmal atrial fibrillation
Authors
Issue Date2007
PublisherOxford University Press. The Journal's web site is located at http://europace.oxfordjournals.org/
Citation
Europace, 2007, v. 9 n. 9, p. 798-804 How to Cite?
AbstractAims: Paroxysmal atrial fibrillation (PAF) is frequently encountered in pacemaker patients, most commonly in sick sinus syndrome. The combination of site-specific pacing in conjunction with an overdrive algorithm combined with antiarrhythmic drugs on the incidence of PAF in patients with a conventional indication for pacing is unknown. Methods and results: Patients with pacemaker indication and PAF received a DDDR-pacemaker, which included an automatic atrial overdrive (AO) algorithm. The atrial lead was implanted in either the right atrial appendage (RAA) (n = 83) or the right low-atrial septum (LAS) (n = 94). The algorithm was switched on or off in a 3 month, single blind crossover design and antiarrhythmic drugs were kept stable. A control group of 96 patients (LAS, n = 14; RAA, n = 84) without PAF served as controls to assess any proarrhythmic effect of overdrive pacing. Atrial fibrillation (AF) burden defined as cumulative time in mode switch was not reduced during automatic AO from either the RAA or from the LAS. The reduction was not effective both for AF of short (<24 h) and long (≥24 h) duration. There was no atrial proarrhythmia induced by the overdrive algorithm in the control group. Conclusions: We could not demonstrate a reduction of AF burden defined as cumulative time in AF by the AO algorithm, in patients who are paced for standard indications and PAF, neither from the RAA nor from the LAS. © The European Society of Cardiology 2007. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/76263
ISSN
2015 Impact Factor: 4.021
2015 SCImago Journal Rankings: 2.201
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorde Voogt, Wen_HK
dc.contributor.authorvan Hemel, Nen_HK
dc.contributor.authorde Vusser, Pen_HK
dc.contributor.authorMairesse, GHen_HK
dc.contributor.authorvan Mechelen, Ren_HK
dc.contributor.authorKoistinen, Jen_HK
dc.contributor.authorvan den Bos, Aen_HK
dc.contributor.authorRoose, Ien_HK
dc.contributor.authorVoitk, Jen_HK
dc.contributor.authorYliMäyry, Sen_HK
dc.contributor.authorStockman, Den_HK
dc.contributor.authorEl Allaf, Den_HK
dc.contributor.authorTse, HFen_HK
dc.contributor.authorLau, CPen_HK
dc.date.accessioned2010-09-06T07:19:22Z-
dc.date.available2010-09-06T07:19:22Z-
dc.date.issued2007en_HK
dc.identifier.citationEuropace, 2007, v. 9 n. 9, p. 798-804en_HK
dc.identifier.issn1099-5129en_HK
dc.identifier.urihttp://hdl.handle.net/10722/76263-
dc.description.abstractAims: Paroxysmal atrial fibrillation (PAF) is frequently encountered in pacemaker patients, most commonly in sick sinus syndrome. The combination of site-specific pacing in conjunction with an overdrive algorithm combined with antiarrhythmic drugs on the incidence of PAF in patients with a conventional indication for pacing is unknown. Methods and results: Patients with pacemaker indication and PAF received a DDDR-pacemaker, which included an automatic atrial overdrive (AO) algorithm. The atrial lead was implanted in either the right atrial appendage (RAA) (n = 83) or the right low-atrial septum (LAS) (n = 94). The algorithm was switched on or off in a 3 month, single blind crossover design and antiarrhythmic drugs were kept stable. A control group of 96 patients (LAS, n = 14; RAA, n = 84) without PAF served as controls to assess any proarrhythmic effect of overdrive pacing. Atrial fibrillation (AF) burden defined as cumulative time in mode switch was not reduced during automatic AO from either the RAA or from the LAS. The reduction was not effective both for AF of short (<24 h) and long (≥24 h) duration. There was no atrial proarrhythmia induced by the overdrive algorithm in the control group. Conclusions: We could not demonstrate a reduction of AF burden defined as cumulative time in AF by the AO algorithm, in patients who are paced for standard indications and PAF, neither from the RAA nor from the LAS. © The European Society of Cardiology 2007. All rights reserved.en_HK
dc.languageengen_HK
dc.publisherOxford University Press. The Journal's web site is located at http://europace.oxfordjournals.org/en_HK
dc.relation.ispartofEuropaceen_HK
dc.rightsEuropace . Copyright © Oxford University Press.en_HK
dc.subject.meshAgeden_HK
dc.subject.meshAlgorithmsen_HK
dc.subject.meshAnti-Arrhythmia Agents - pharmacologyen_HK
dc.subject.meshAtrial Fibrillation - physiopathology - therapyen_HK
dc.subject.meshAtrial Functionen_HK
dc.subject.meshCardiac Pacing, Artificial - methodsen_HK
dc.subject.meshCardiology - methodsen_HK
dc.subject.meshCross-Over Studiesen_HK
dc.subject.meshFemaleen_HK
dc.subject.meshHumansen_HK
dc.subject.meshMaleen_HK
dc.subject.meshMiddle Ageden_HK
dc.subject.meshPacemaker, Artificialen_HK
dc.subject.meshTachycardia, Paroxysmal - physiopathology - therapyen_HK
dc.subject.meshTreatment Outcomeen_HK
dc.titleNo evidence of automatic atrial overdrive pacing efficacy on reduction of paroxysmal atrial fibrillationen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1099-5129&volume=9&issue=9&spage=798&epage=804&date=2007&atitle=No+evidence+of+automatic+atrial+overdrive+pacing+efficacy+on+reduction+of+paroxysmal+atrial+fibrillationen_HK
dc.identifier.emailTse, HF:hftse@hkucc.hku.hken_HK
dc.identifier.authorityTse, HF=rp00428en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1093/europace/eum149en_HK
dc.identifier.pmid17670782-
dc.identifier.scopuseid_2-s2.0-34548511563en_HK
dc.identifier.hkuros136561en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-34548511563&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume9en_HK
dc.identifier.issue9en_HK
dc.identifier.spage798en_HK
dc.identifier.epage804en_HK
dc.identifier.isiWOS:000249945200018-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridde Voogt, W=6602736165en_HK
dc.identifier.scopusauthoridvan Hemel, N=7006429577en_HK
dc.identifier.scopusauthoridde Vusser, P=7409772886en_HK
dc.identifier.scopusauthoridMairesse, GH=7003921830en_HK
dc.identifier.scopusauthoridvan Mechelen, R=6701827154en_HK
dc.identifier.scopusauthoridKoistinen, J=7007161879en_HK
dc.identifier.scopusauthoridvan den Bos, A=7006915949en_HK
dc.identifier.scopusauthoridRoose, I=21234252700en_HK
dc.identifier.scopusauthoridVoitk, J=6505615683en_HK
dc.identifier.scopusauthoridYliMäyry, S=6701511838en_HK
dc.identifier.scopusauthoridStockman, D=6701762664en_HK
dc.identifier.scopusauthoridEl Allaf, D=7003475097en_HK
dc.identifier.scopusauthoridTse, HF=7006070805en_HK
dc.identifier.scopusauthoridLau, CP=35275317200en_HK

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