File Download

There are no files associated with this item.

  Links for fulltext
     (May Require Subscription)
  • Find via Find It@HKUL
Supplementary

Article: Effect of Buyang Huanwu Decoction (補陽還五湯) on cerebral nitric oxide synthase level during focal cerebral ischemia in mice

TitleEffect of Buyang Huanwu Decoction (補陽還五湯) on cerebral nitric oxide synthase level during focal cerebral ischemia in mice
補陽還五湯對小鼠腦缺血后NOS活性的影響
Authors
KeywordsCerebral ischemia
Nitric oxide synthase
Buyang Huanwu Decoction (補陽還五湯)
Issue Date2003
Publisher中國藥理學會. The Journal's web site is located at http://zyyl.chinajournal.net.cn/
Citation
Pharmacology and Chinese Material Medicine, 2003, v. 19 n. 4, p. 5-7 How to Cite?
中藥藥理与臨床, 2003, v. 19 n. 4, p. 5-7 How to Cite?
Abstract目的 :觀察補陽還五湯對小鼠局灶性腦缺血后腦組織內NOS活性的影響。方法 :局灶性腦缺血模型由絲線結扎一側帶迷走神經的頸總動脈制成 ,用NOS試劑盒和紫外分光光度法測定NOS活性。結果 :缺血后腦組織內NOS顯著升高 ,以缺血 4h達高峰 ,補陽還五湯組NOS活性比缺血對照組顯著降低 ,以缺血 4h最明顯。結論 :補陽還五湯能抑制缺血后腦組織內NOS活性的升高 ,對缺血后腦組織具有保護作用。
Objective: The purpose of this study was to observe the effect of Buyang Huanwu Decoction (BYHWD) on cerebral nitric oxide synthase level during focal cerebral ischemia in mice. Methods: Focal cerebral ischemia was produced by ligatad with a ligature of 1.0 suture material around left common carotid artery and its vagus nerve in urethane anestheticzed mice. The activity of brain nitric oxide synthase was measured by NOS reagent salver through ultraviolet spectroscopy. Results: The results showed that the activity of NOS in the cerebral tissue was increased in the ischemic hemisphere after induction of ischemia especially at 4 hours after the onset of ischemia. BYHWD group significantly decreased compared with cerebral ischemic group (P<0.05), especially at 4 hours after the onset of ischemia. Conclusion: BYHWD could significantly restrain the up regulated activity of NOS after focal cerebral ischemia to protect the cerebral ischemic lesion, especially at 4 hours after the onset of ischemia.
Persistent Identifierhttp://hdl.handle.net/10722/76262
ISSN

 

DC FieldValueLanguage
dc.contributor.authorLiao, CLen_HK
dc.contributor.authorTong, Len_HK
dc.contributor.authorShen, Jen_HK
dc.date.accessioned2010-09-06T07:19:21Z-
dc.date.available2010-09-06T07:19:21Z-
dc.date.issued2003en_HK
dc.identifier.citationPharmacology and Chinese Material Medicine, 2003, v. 19 n. 4, p. 5-7en_HK
dc.identifier.citation中藥藥理与臨床, 2003, v. 19 n. 4, p. 5-7zh_HK
dc.identifier.issn1001-859X-
dc.identifier.urihttp://hdl.handle.net/10722/76262-
dc.description.abstract目的 :觀察補陽還五湯對小鼠局灶性腦缺血后腦組織內NOS活性的影響。方法 :局灶性腦缺血模型由絲線結扎一側帶迷走神經的頸總動脈制成 ,用NOS試劑盒和紫外分光光度法測定NOS活性。結果 :缺血后腦組織內NOS顯著升高 ,以缺血 4h達高峰 ,補陽還五湯組NOS活性比缺血對照組顯著降低 ,以缺血 4h最明顯。結論 :補陽還五湯能抑制缺血后腦組織內NOS活性的升高 ,對缺血后腦組織具有保護作用。-
dc.description.abstractObjective: The purpose of this study was to observe the effect of Buyang Huanwu Decoction (BYHWD) on cerebral nitric oxide synthase level during focal cerebral ischemia in mice. Methods: Focal cerebral ischemia was produced by ligatad with a ligature of 1.0 suture material around left common carotid artery and its vagus nerve in urethane anestheticzed mice. The activity of brain nitric oxide synthase was measured by NOS reagent salver through ultraviolet spectroscopy. Results: The results showed that the activity of NOS in the cerebral tissue was increased in the ischemic hemisphere after induction of ischemia especially at 4 hours after the onset of ischemia. BYHWD group significantly decreased compared with cerebral ischemic group (P<0.05), especially at 4 hours after the onset of ischemia. Conclusion: BYHWD could significantly restrain the up regulated activity of NOS after focal cerebral ischemia to protect the cerebral ischemic lesion, especially at 4 hours after the onset of ischemia.-
dc.languagechien_HK
dc.languagechi-
dc.publisher中國藥理學會. The Journal's web site is located at http://zyyl.chinajournal.net.cn/-
dc.relation.ispartofPharmacology and Chinese Material Medicineen_HK
dc.relation.ispartof中藥藥理与臨床zh_HK
dc.subjectCerebral ischemia-
dc.subjectNitric oxide synthase-
dc.subjectBuyang Huanwu Decoction (補陽還五湯)-
dc.titleEffect of Buyang Huanwu Decoction (補陽還五湯) on cerebral nitric oxide synthase level during focal cerebral ischemia in miceen_HK
dc.title補陽還五湯對小鼠腦缺血后NOS活性的影響zh_HK
dc.typeArticleen_HK
dc.identifier.emailShen, J: shenjg@hkucc.hku.hken_HK
dc.identifier.authorityShen, J=rp00487en_HK
dc.identifier.hkuros88467en_HK

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats