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Article: Relationship of circulating endothelial progenitor cells to the recurrence of atrial fibrillation after successful conversion and maintenance of sinus rhythm

TitleRelationship of circulating endothelial progenitor cells to the recurrence of atrial fibrillation after successful conversion and maintenance of sinus rhythm
Authors
KeywordsAtrial fibrillation
Electrical cardioversion
Endothelial progenitor cells
Issue Date2010
PublisherOxford University Press. The Journal's web site is located at http://europace.oxfordjournals.org/
Citation
Europace, 2010, v. 12 n. 4, p. 517-521 How to Cite?
AbstractAims To determine whether the number of circulating endothelial progenitor cells (EPCs) in patients with persistent atrial fibrillation (AF) predicts arrhythmia recurrence after direct current cardioversion (DCCV).Methods and resultsThe numbers of circulating CD34 +/KDR + EPCs were determined with flow cytometry in 51 consecutive patients with persistent AF [the mean age: 67 ± 1.3 years, male (65)] prior to DCCV and were compared with that of age- and sex-matched controls, and cohorts of patients with coronary artery disease and ischaemic stroke. The AF recurrence rate at 1 year was also determined. The EPCs in patients with persistent AF, patients with coronary artery disease, and patients with ischaemic stroke were significantly lower than that of the age- and sex-matched controls (P < 0.01). One year after successful DCCV, patients with high EPC count (50th to 100th percentile) had a higher recurrence rate of AF when compared with those with low EPC count (less than 50th percentile) (73 vs. 40, P = 0.02). Cox regression analysis revealed the high EPC count was the only independent predictors for the AF recurrence (HR: 2.29, P = 0.047).ConclusionThe number of EPCs is reduced in patients with persistent AF and predicts the recurrence of AF after successful DCCV. © 2009 The Author.
Persistent Identifierhttp://hdl.handle.net/10722/76242
ISSN
2015 Impact Factor: 4.021
2015 SCImago Journal Rankings: 2.201
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorSiu, CWen_HK
dc.contributor.authorWatson, Ten_HK
dc.contributor.authorLai, WHen_HK
dc.contributor.authorLee, YKen_HK
dc.contributor.authorChan, YHen_HK
dc.contributor.authorNg, KMen_HK
dc.contributor.authorLau, CPen_HK
dc.contributor.authorLip, GYHen_HK
dc.contributor.authorTse, HFen_HK
dc.date.accessioned2010-09-06T07:19:08Z-
dc.date.available2010-09-06T07:19:08Z-
dc.date.issued2010en_HK
dc.identifier.citationEuropace, 2010, v. 12 n. 4, p. 517-521en_HK
dc.identifier.issn1099-5129en_HK
dc.identifier.urihttp://hdl.handle.net/10722/76242-
dc.description.abstractAims To determine whether the number of circulating endothelial progenitor cells (EPCs) in patients with persistent atrial fibrillation (AF) predicts arrhythmia recurrence after direct current cardioversion (DCCV).Methods and resultsThe numbers of circulating CD34 +/KDR + EPCs were determined with flow cytometry in 51 consecutive patients with persistent AF [the mean age: 67 ± 1.3 years, male (65)] prior to DCCV and were compared with that of age- and sex-matched controls, and cohorts of patients with coronary artery disease and ischaemic stroke. The AF recurrence rate at 1 year was also determined. The EPCs in patients with persistent AF, patients with coronary artery disease, and patients with ischaemic stroke were significantly lower than that of the age- and sex-matched controls (P < 0.01). One year after successful DCCV, patients with high EPC count (50th to 100th percentile) had a higher recurrence rate of AF when compared with those with low EPC count (less than 50th percentile) (73 vs. 40, P = 0.02). Cox regression analysis revealed the high EPC count was the only independent predictors for the AF recurrence (HR: 2.29, P = 0.047).ConclusionThe number of EPCs is reduced in patients with persistent AF and predicts the recurrence of AF after successful DCCV. © 2009 The Author.en_HK
dc.languageengen_HK
dc.publisherOxford University Press. The Journal's web site is located at http://europace.oxfordjournals.org/en_HK
dc.relation.ispartofEuropaceen_HK
dc.subjectAtrial fibrillationen_HK
dc.subjectElectrical cardioversionen_HK
dc.subjectEndothelial progenitor cellsen_HK
dc.subject.meshAged-
dc.subject.meshAtrial Fibrillation - pathology - therapy-
dc.subject.meshElectric Countershock-
dc.subject.meshEndothelial Cells - cytology-
dc.subject.meshHematopoietic Stem Cells - cytology-
dc.titleRelationship of circulating endothelial progenitor cells to the recurrence of atrial fibrillation after successful conversion and maintenance of sinus rhythmen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1099-5129&volume=12&issue=4&spage=517&epage=521&date=2010&atitle=Relationship+of+circulating+endothelial+progenitor+cells+to+the+recurrence+of+atrial+fibrillation+after+successful+conversion+and+maintenance+of+sinus+rhythmen_HK
dc.identifier.emailSiu, CW:cwdsiu@hkucc.hku.hken_HK
dc.identifier.emailChan, YH:chanwill@hku.hken_HK
dc.identifier.emailTse, HF:hftse@hkucc.hku.hken_HK
dc.identifier.authoritySiu, CW=rp00534en_HK
dc.identifier.authorityChan, YH=rp01313en_HK
dc.identifier.authorityTse, HF=rp00428en_HK
dc.description.naturelink_to_OA_fulltext-
dc.identifier.doi10.1093/europace/eup382en_HK
dc.identifier.pmid19951966-
dc.identifier.scopuseid_2-s2.0-77950193639en_HK
dc.identifier.hkuros169697en_HK
dc.identifier.hkuros201070-
dc.identifier.hkuros168418-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-77950193639&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume12en_HK
dc.identifier.issue4en_HK
dc.identifier.spage517en_HK
dc.identifier.epage521en_HK
dc.identifier.isiWOS:000276049400016-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridSiu, CW=7006550690en_HK
dc.identifier.scopusauthoridWatson, T=7202562757en_HK
dc.identifier.scopusauthoridLai, WH=18434390500en_HK
dc.identifier.scopusauthoridLee, YK=25958641200en_HK
dc.identifier.scopusauthoridChan, YH=22633700600en_HK
dc.identifier.scopusauthoridNg, KM=25122990200en_HK
dc.identifier.scopusauthoridLau, CP=7401968501en_HK
dc.identifier.scopusauthoridLip, GYH=35351259800en_HK
dc.identifier.scopusauthoridTse, HF=7006070805en_HK

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