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Article: Evaluation of an automated immunochemical fecal occult blood test for colorectal neoplasia detection in a Chinese population

TitleEvaluation of an automated immunochemical fecal occult blood test for colorectal neoplasia detection in a Chinese population
Authors
KeywordsAdenoma
Colon carcinoma
Colorectal neoplasia
Screening
Issue Date2003
PublisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/28741
Citation
Cancer, 2003, v. 97 n. 10, p. 2420-2424 How to Cite?
AbstractBACKGROUND. Most commercial fecal occult blood tests (FOBT) used for colorectal carcinoma screening of Western populations are guaiac-based, manually developed, subjective, and sensitive to dietary components. Preliminary studies demonstrated the unsuitability of these tests for screening a Chinese population. The goal of the current study was to evaluate the performance characteristics of a human hemoglobin-specific automated immunochemical FOBT, the Magstream 1000/Hem SP (Fujirebio, Inc., Tokyo, Japan), in a Chinese population referred for colonoscopy. METHODS. Two hundred fifty consecutive patients who were referred for colonoscopy and met the study inclusion criteria provided samples for the immunochemical FOBT (without dietary restrictions) from two successive stool specimens. Tests were developed with an automated instrument that had an adjustable sensitivity threshold. The sensitivity, specificity, and positive predictive value for detecting colorectal adenomas and carcinomas were calculated according to the manufacturer's instructions over a range of sensitivity levels. RESULTS. At the optimal threshold level, the sensitivity, specificity, and positive predictive value for detection of significant colorectal neoplasia (adenomas ≥ 1.0 cm and carcinomas) were 62%, 93%, and 44%, respectively. The test was easy to use, and results did not depend on operator experience. CONCLUSIONS. The automated immunochemical FOBT used in the current study was a robust, convenient, and useful tool for colorectal carcinoma screening in the study population. © 2003 American Cancer Society.
Persistent Identifierhttp://hdl.handle.net/10722/76225
ISSN
2015 Impact Factor: 5.649
2015 SCImago Journal Rankings: 3.188
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorWong, WMen_HK
dc.contributor.authorLam, SKen_HK
dc.contributor.authorCheung, KLen_HK
dc.contributor.authorTong, TSMen_HK
dc.contributor.authorRozen, Pen_HK
dc.contributor.authorYoung, GPen_HK
dc.contributor.authorChu, KWen_HK
dc.contributor.authorHo, Jen_HK
dc.contributor.authorLaw, WLen_HK
dc.contributor.authorTung, HMen_HK
dc.contributor.authorChoi, HKen_HK
dc.contributor.authorLee, YMen_HK
dc.contributor.authorLai, KCen_HK
dc.contributor.authorHu, WHCen_HK
dc.contributor.authorChan, CKen_HK
dc.contributor.authorYuen, MFen_HK
dc.contributor.authorWong, BCYen_HK
dc.date.accessioned2010-09-06T07:18:56Z-
dc.date.available2010-09-06T07:18:56Z-
dc.date.issued2003en_HK
dc.identifier.citationCancer, 2003, v. 97 n. 10, p. 2420-2424en_HK
dc.identifier.issn0008-543Xen_HK
dc.identifier.urihttp://hdl.handle.net/10722/76225-
dc.description.abstractBACKGROUND. Most commercial fecal occult blood tests (FOBT) used for colorectal carcinoma screening of Western populations are guaiac-based, manually developed, subjective, and sensitive to dietary components. Preliminary studies demonstrated the unsuitability of these tests for screening a Chinese population. The goal of the current study was to evaluate the performance characteristics of a human hemoglobin-specific automated immunochemical FOBT, the Magstream 1000/Hem SP (Fujirebio, Inc., Tokyo, Japan), in a Chinese population referred for colonoscopy. METHODS. Two hundred fifty consecutive patients who were referred for colonoscopy and met the study inclusion criteria provided samples for the immunochemical FOBT (without dietary restrictions) from two successive stool specimens. Tests were developed with an automated instrument that had an adjustable sensitivity threshold. The sensitivity, specificity, and positive predictive value for detecting colorectal adenomas and carcinomas were calculated according to the manufacturer's instructions over a range of sensitivity levels. RESULTS. At the optimal threshold level, the sensitivity, specificity, and positive predictive value for detection of significant colorectal neoplasia (adenomas ≥ 1.0 cm and carcinomas) were 62%, 93%, and 44%, respectively. The test was easy to use, and results did not depend on operator experience. CONCLUSIONS. The automated immunochemical FOBT used in the current study was a robust, convenient, and useful tool for colorectal carcinoma screening in the study population. © 2003 American Cancer Society.en_HK
dc.languageengen_HK
dc.publisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/28741en_HK
dc.relation.ispartofCanceren_HK
dc.rightsCancer . Copyright © John Wiley & Sons, Inc.en_HK
dc.subjectAdenomaen_HK
dc.subjectColon carcinomaen_HK
dc.subjectColorectal neoplasiaen_HK
dc.subjectScreeningen_HK
dc.titleEvaluation of an automated immunochemical fecal occult blood test for colorectal neoplasia detection in a Chinese populationen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0008-543X&volume=17&issue=4&spage=553&epage=60&date=2003&atitle=Evaluation+of+an+automated+immunochemical+fecal+occult+blood+test+for+colorectal+neoplasia+detection+in+a+Chinese+populationen_HK
dc.identifier.emailLaw, WL: lawwl@hkucc.hku.hken_HK
dc.identifier.emailYuen, MF: mfyuen@hkucc.hku.hken_HK
dc.identifier.emailWong, BCY: bcywong@hku.hken_HK
dc.identifier.authorityLaw, WL=rp00436en_HK
dc.identifier.authorityYuen, MF=rp00479en_HK
dc.identifier.authorityWong, BCY=rp00429en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1002/cncr.11369en_HK
dc.identifier.scopuseid_2-s2.0-0038709308en_HK
dc.identifier.hkuros131144en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0038709308&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume97en_HK
dc.identifier.issue10en_HK
dc.identifier.spage2420en_HK
dc.identifier.epage2424en_HK
dc.identifier.isiWOS:000182665900005-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridWong, WM=7403972413en_HK
dc.identifier.scopusauthoridLam, SK=7402279473en_HK
dc.identifier.scopusauthoridCheung, KL=7402406543en_HK
dc.identifier.scopusauthoridTong, TSM=7102587364en_HK
dc.identifier.scopusauthoridRozen, P=7006399927en_HK
dc.identifier.scopusauthoridYoung, GP=7402900227en_HK
dc.identifier.scopusauthoridChu, KW=7402453653en_HK
dc.identifier.scopusauthoridHo, J=7402649983en_HK
dc.identifier.scopusauthoridLaw, WL=7103147867en_HK
dc.identifier.scopusauthoridTung, HM=7006351410en_HK
dc.identifier.scopusauthoridChoi, HK=7404339913en_HK
dc.identifier.scopusauthoridLee, YM=8521465600en_HK
dc.identifier.scopusauthoridLai, KC=7402135595en_HK
dc.identifier.scopusauthoridHu, WHC=25932937100en_HK
dc.identifier.scopusauthoridChan, CK=7404813960en_HK
dc.identifier.scopusauthoridYuen, MF=7102031955en_HK
dc.identifier.scopusauthoridWong, BCY=7402023340en_HK

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