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Article: Fabrication and characterization of composite microspheres containing carbonated hydroxyapatite nanoparticles

TitleFabrication and characterization of composite microspheres containing carbonated hydroxyapatite nanoparticles
Authors
KeywordsBone tissue engineering
Carbonated hydroxyapatite
Composite microsphere
Nanoparticle
Poly(L-lactide)
Issue Date2007
PublisherTrans Tech Publications Ltd. The Journal's web site is located at http://www.scientific.net
Citation
Key Engineering Materials, 2007, v. 334-335 II, p. 1221-1224 How to Cite?
AbstractNano-sized carbonated hydroxyapatite (CHAp) particles were firstly synthesized using a nanoemulsion method. TEM analyses revealed that as-synthesized nanoparticles were calcium-deficient and spherical in shape (diameter: 16.8±2.6nm). Biocomposite microspheres comprising CHAp nanoparticles and poly(L-lactide) (PLLA) were fabricated using the single emulsion solvent evaporation technique. SEM images showed that composite microspheres were mainly 5-30 μm in size despite the change of CHAp nanoparticle content. When the CHAp nanoparticle content in composite microspheres was below 10 wt%, all nanoparticles were encapsulated within the microspheres which possessed a nanocomposite structure. DSC results showed that the crystallinity of the PLLA matrix of microspheres increased from 38 to 42% when the CHAp nanoparticle content was increased from 0 to 20 wt%. The biocomposite microspheres should be a suitable material for constructing bone tissue engineering scaffolds.
Persistent Identifierhttp://hdl.handle.net/10722/76212
ISSN
2023 SCImago Journal Rankings: 0.172
References

 

DC FieldValueLanguage
dc.contributor.authorZhou, WYen_HK
dc.contributor.authorWang, Men_HK
dc.contributor.authorCheung, WLen_HK
dc.date.accessioned2010-09-06T07:18:43Z-
dc.date.available2010-09-06T07:18:43Z-
dc.date.issued2007en_HK
dc.identifier.citationKey Engineering Materials, 2007, v. 334-335 II, p. 1221-1224en_HK
dc.identifier.issn1013-9826en_HK
dc.identifier.urihttp://hdl.handle.net/10722/76212-
dc.description.abstractNano-sized carbonated hydroxyapatite (CHAp) particles were firstly synthesized using a nanoemulsion method. TEM analyses revealed that as-synthesized nanoparticles were calcium-deficient and spherical in shape (diameter: 16.8±2.6nm). Biocomposite microspheres comprising CHAp nanoparticles and poly(L-lactide) (PLLA) were fabricated using the single emulsion solvent evaporation technique. SEM images showed that composite microspheres were mainly 5-30 μm in size despite the change of CHAp nanoparticle content. When the CHAp nanoparticle content in composite microspheres was below 10 wt%, all nanoparticles were encapsulated within the microspheres which possessed a nanocomposite structure. DSC results showed that the crystallinity of the PLLA matrix of microspheres increased from 38 to 42% when the CHAp nanoparticle content was increased from 0 to 20 wt%. The biocomposite microspheres should be a suitable material for constructing bone tissue engineering scaffolds.en_HK
dc.languageengen_HK
dc.publisherTrans Tech Publications Ltd. The Journal's web site is located at http://www.scientific.neten_HK
dc.relation.ispartofKey Engineering Materialsen_HK
dc.rightsKey Engineering Materials. Copyright © Trans Tech Publications Ltd.en_HK
dc.subjectBone tissue engineeringen_HK
dc.subjectCarbonated hydroxyapatiteen_HK
dc.subjectComposite microsphereen_HK
dc.subjectNanoparticleen_HK
dc.subjectPoly(L-lactide)en_HK
dc.titleFabrication and characterization of composite microspheres containing carbonated hydroxyapatite nanoparticlesen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1013-9826&volume=334-335&spage=1221&epage=1224&date=2007&atitle=Fabrication+and+characterization+of+composite+microspheres+containing+carbonated+hydroxyapatite+nanoparticlesen_HK
dc.identifier.emailZhou, WY:wzhou@business.hku.hken_HK
dc.identifier.emailWang, M:memwang@hku.hken_HK
dc.identifier.emailCheung, WL:wlcheung@hkucc.hku.hken_HK
dc.identifier.authorityZhou, WY=rp01128en_HK
dc.identifier.authorityWang, M=rp00185en_HK
dc.identifier.authorityCheung, WL=rp00103en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.scopuseid_2-s2.0-33847020448en_HK
dc.identifier.hkuros132263en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-33847020448&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume334-335 IIen_HK
dc.identifier.spage1221en_HK
dc.identifier.epage1224en_HK
dc.publisher.placeSwitzerlanden_HK
dc.identifier.scopusauthoridZhou, WY=10739745800en_HK
dc.identifier.scopusauthoridWang, M=15749714100en_HK
dc.identifier.scopusauthoridCheung, WL=7202743084en_HK
dc.identifier.issnl1013-9826-

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