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Article: Hybrid nanofibrous membranes of PLGA/chitosan fabricated via an electrospinning array

TitleHybrid nanofibrous membranes of PLGA/chitosan fabricated via an electrospinning array
Authors
KeywordsChitosan
Cytocompatibility
Electrospinning array
Nanofibrous membrane
PLGA
Issue Date2007
PublisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www.interscience.wiley.com/jpages/0021-9304/
Citation
Journal Of Biomedical Materials Research - Part A, 2007, v. 83 n. 3, p. 868-878 How to Cite?
AbstractHybrid nanofibrous membranes of poly(lactic-co-glycolic acid) (PLGA) and chitosan with different chitosan amounts (32.3, 62.7, and 86.5%) were fabricated via a specially designed electrospinning setup consisting of two sets of separate syringe pumps and power supplies. After soaking in chloroform overnight to dissolve PLGA, the amount of chitosan in the hybrid membranes was determined. The structure, mechanical properties, water uptake, and cytocompatibilities of the nanofibrous membranes were investigated by scanning electron microscopy, tensile testing, incubation in phosphate buffer solution, and human embryo skin fibroblasts culturing. Results showed that the chitosan amount in PLGA/chitosan membranes could be well controlled by adjusting the number of syringe for electrospinning of PLGA or chitosan, respectively. Because of the introduction of chitosan, which is a naturally hydrophilic polymer, the hybrid PLGA/chitosan membranes after chitosan crosslinking exhibited good mechanical and water absorption properties. The cytocompatibility of hybrid PLGA/chitosan membranes was better than that of the electrospun PLGA membrane. The electrospun hybrid nanofibrous membranes of PLGA and chitosan appear to be promising for skin tissue engineering. The concept of using an electrospinning array to form multicomponent nanofibrous membranes will lead to the creation of novel scaffolds for tissue engineering applications. © 2007 Wiley Periodicals, Inc.
Persistent Identifierhttp://hdl.handle.net/10722/76193
ISSN
2015 Impact Factor: 3.263
2015 SCImago Journal Rankings: 0.979
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorDuan, Ben_HK
dc.contributor.authorWu, Len_HK
dc.contributor.authorYuan, Xen_HK
dc.contributor.authorHu, Zen_HK
dc.contributor.authorLi, Xen_HK
dc.contributor.authorZhang, Yen_HK
dc.contributor.authorYao, Ken_HK
dc.contributor.authorWang, Men_HK
dc.date.accessioned2010-09-06T07:18:32Z-
dc.date.available2010-09-06T07:18:32Z-
dc.date.issued2007en_HK
dc.identifier.citationJournal Of Biomedical Materials Research - Part A, 2007, v. 83 n. 3, p. 868-878en_HK
dc.identifier.issn1549-3296en_HK
dc.identifier.urihttp://hdl.handle.net/10722/76193-
dc.description.abstractHybrid nanofibrous membranes of poly(lactic-co-glycolic acid) (PLGA) and chitosan with different chitosan amounts (32.3, 62.7, and 86.5%) were fabricated via a specially designed electrospinning setup consisting of two sets of separate syringe pumps and power supplies. After soaking in chloroform overnight to dissolve PLGA, the amount of chitosan in the hybrid membranes was determined. The structure, mechanical properties, water uptake, and cytocompatibilities of the nanofibrous membranes were investigated by scanning electron microscopy, tensile testing, incubation in phosphate buffer solution, and human embryo skin fibroblasts culturing. Results showed that the chitosan amount in PLGA/chitosan membranes could be well controlled by adjusting the number of syringe for electrospinning of PLGA or chitosan, respectively. Because of the introduction of chitosan, which is a naturally hydrophilic polymer, the hybrid PLGA/chitosan membranes after chitosan crosslinking exhibited good mechanical and water absorption properties. The cytocompatibility of hybrid PLGA/chitosan membranes was better than that of the electrospun PLGA membrane. The electrospun hybrid nanofibrous membranes of PLGA and chitosan appear to be promising for skin tissue engineering. The concept of using an electrospinning array to form multicomponent nanofibrous membranes will lead to the creation of novel scaffolds for tissue engineering applications. © 2007 Wiley Periodicals, Inc.en_HK
dc.languageengen_HK
dc.publisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www.interscience.wiley.com/jpages/0021-9304/en_HK
dc.relation.ispartofJournal of Biomedical Materials Research - Part Aen_HK
dc.rightsJournal of Biomedical Materials Research Part A. Copyright © John Wiley & Sons, Inc.en_HK
dc.subjectChitosanen_HK
dc.subjectCytocompatibilityen_HK
dc.subjectElectrospinning arrayen_HK
dc.subjectNanofibrous membraneen_HK
dc.subjectPLGAen_HK
dc.subject.meshChitosan - chemistry-
dc.subject.meshEmbryo, Mammalian - cytology-
dc.subject.meshFibroblasts - cytology-
dc.subject.meshLactic Acid - chemistry-
dc.subject.meshMembranes, Artificial-
dc.titleHybrid nanofibrous membranes of PLGA/chitosan fabricated via an electrospinning arrayen_HK
dc.typeArticleen_HK
dc.identifier.emailWang, M:memwang@hku.hken_HK
dc.identifier.authorityWang, M=rp00185en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1002/jbm.a.31408en_HK
dc.identifier.pmid17567858-
dc.identifier.scopuseid_2-s2.0-36048953857en_HK
dc.identifier.hkuros148089en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-36048953857&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume83en_HK
dc.identifier.issue3en_HK
dc.identifier.spage868en_HK
dc.identifier.epage878en_HK
dc.identifier.isiWOS:000250742700034-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridDuan, B=7005042335en_HK
dc.identifier.scopusauthoridWu, L=8960230000en_HK
dc.identifier.scopusauthoridYuan, X=7402202655en_HK
dc.identifier.scopusauthoridHu, Z=37065552900en_HK
dc.identifier.scopusauthoridLi, X=8531117500en_HK
dc.identifier.scopusauthoridZhang, Y=22954628200en_HK
dc.identifier.scopusauthoridYao, K=7403234424en_HK
dc.identifier.scopusauthoridWang, M=15749714100en_HK

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