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Article: Nano-mechanics of bone and bioactive bone cement interfaces in a load-bearing model
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TitleNano-mechanics of bone and bioactive bone cement interfaces in a load-bearing model
 
AuthorsNi, GX1
Choy, YS1
Lu, WW1
Ngan, AHW1
Chiu, KY1
Li, ZY1
Tang, B1
Luk, KDK1
 
KeywordsBioactive bone cement
Interface
Mechanical property
Nanoindentation
Total hip arthroplasty
 
Issue Date2006
 
PublisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/biomaterials
 
CitationBiomaterials, 2006, v. 27 n. 9, p. 1963-1970 [How to Cite?]
DOI: http://dx.doi.org/10.1016/j.biomaterials.2005.09.044
 
AbstractMany bioactive bone cements were developed for total hip replacement and found to bond with bone directly. However, the mechanical properties at the bone/bone cement interface under load bearing are not fully understood. In this study, a bioactive bone cement, which consists of strontium-containing hydroxyapatite (Sr-HA) powder and bisphenol-α-glycidyl dimethacrylate (Bis-GMA)-based resin, was evaluated in rabbit hip replacement for 6 months, and the mechanical properties of interfaces of cancellous bone/Sr-HA cement and cortical bone/Sr-HA cement were investigated by nanoindentation. The results showed that Young's modulus (17.6±4.2 GPa) and hardness (987.6±329.2 MPa) at interface between cancellous bone and Sr-HA cement were significantly higher than those at the cancellous bone (12.7±1.7 GPa; 632.7±108.4 MPa)and Sr-HA cement (5.2±0.5 GPa; 265.5±39.2 MPa); whereas Young's modulus (6.3±2.8 GPa) and hardness (417.4±164.5 MPa) at interface between cortical bone and Sr-HA cement were significantly lower than those at cortical bone(12.9±2.2 GPa; 887.9±162.0 MPa), but significantly higher than Sr-HA cement(3.6±0.3 GPa; 239.1±30.4 MPa). The results of the mechanical properties of the interfaces were supported by the histological observation and chemical composition. Osseointegration of Sr-HA cement with cancellous bone was observed. An apatite layer with high content of calcium and phosphorus was found between cancellous bone and Sr-HA cement. However, no such apatite layer was observed at the interface between cortical bone and Sr-HA cement. And the contents of calcium and phosphorus of the interface were lower than those of cortical bone. The mechanical properties indicated that these two interfaces were diffused interfaces, and cancellous bone or cortical bone was grown into Sr-HA cement 6 months after the implantation. © 2005 Elsevier Ltd. All rights reserved.
 
ISSN0142-9612
2013 Impact Factor: 8.312
 
DOIhttp://dx.doi.org/10.1016/j.biomaterials.2005.09.044
 
ISI Accession Number IDWOS:000234962500035
 
ReferencesReferences in Scopus
 
DC FieldValue
dc.contributor.authorNi, GX
 
dc.contributor.authorChoy, YS
 
dc.contributor.authorLu, WW
 
dc.contributor.authorNgan, AHW
 
dc.contributor.authorChiu, KY
 
dc.contributor.authorLi, ZY
 
dc.contributor.authorTang, B
 
dc.contributor.authorLuk, KDK
 
dc.date.accessioned2010-09-06T07:18:14Z
 
dc.date.available2010-09-06T07:18:14Z
 
dc.date.issued2006
 
dc.description.abstractMany bioactive bone cements were developed for total hip replacement and found to bond with bone directly. However, the mechanical properties at the bone/bone cement interface under load bearing are not fully understood. In this study, a bioactive bone cement, which consists of strontium-containing hydroxyapatite (Sr-HA) powder and bisphenol-α-glycidyl dimethacrylate (Bis-GMA)-based resin, was evaluated in rabbit hip replacement for 6 months, and the mechanical properties of interfaces of cancellous bone/Sr-HA cement and cortical bone/Sr-HA cement were investigated by nanoindentation. The results showed that Young's modulus (17.6±4.2 GPa) and hardness (987.6±329.2 MPa) at interface between cancellous bone and Sr-HA cement were significantly higher than those at the cancellous bone (12.7±1.7 GPa; 632.7±108.4 MPa)and Sr-HA cement (5.2±0.5 GPa; 265.5±39.2 MPa); whereas Young's modulus (6.3±2.8 GPa) and hardness (417.4±164.5 MPa) at interface between cortical bone and Sr-HA cement were significantly lower than those at cortical bone(12.9±2.2 GPa; 887.9±162.0 MPa), but significantly higher than Sr-HA cement(3.6±0.3 GPa; 239.1±30.4 MPa). The results of the mechanical properties of the interfaces were supported by the histological observation and chemical composition. Osseointegration of Sr-HA cement with cancellous bone was observed. An apatite layer with high content of calcium and phosphorus was found between cancellous bone and Sr-HA cement. However, no such apatite layer was observed at the interface between cortical bone and Sr-HA cement. And the contents of calcium and phosphorus of the interface were lower than those of cortical bone. The mechanical properties indicated that these two interfaces were diffused interfaces, and cancellous bone or cortical bone was grown into Sr-HA cement 6 months after the implantation. © 2005 Elsevier Ltd. All rights reserved.
 
dc.description.natureLink_to_subscribed_fulltext
 
dc.identifier.citationBiomaterials, 2006, v. 27 n. 9, p. 1963-1970 [How to Cite?]
DOI: http://dx.doi.org/10.1016/j.biomaterials.2005.09.044
 
dc.identifier.doihttp://dx.doi.org/10.1016/j.biomaterials.2005.09.044
 
dc.identifier.epage1970
 
dc.identifier.hkuros148556
 
dc.identifier.isiWOS:000234962500035
 
dc.identifier.issn0142-9612
2013 Impact Factor: 8.312
 
dc.identifier.issue9
 
dc.identifier.openurl
 
dc.identifier.pmid16226309
 
dc.identifier.scopuseid_2-s2.0-28744455189
 
dc.identifier.spage1963
 
dc.identifier.urihttp://hdl.handle.net/10722/76162
 
dc.identifier.volume27
 
dc.languageeng
 
dc.publisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/biomaterials
 
dc.publisher.placeNetherlands
 
dc.relation.ispartofBiomaterials
 
dc.relation.referencesReferences in Scopus
 
dc.rightsBiomaterials . Copyright © Elsevier BV.
 
dc.subject.meshAnimals
 
dc.subject.meshBone Cements - chemistry - therapeutic use - toxicity
 
dc.subject.meshBone and Bones - cytology - drug effects - physiology
 
dc.subject.meshDurapatite - chemistry - therapeutic use
 
dc.subject.meshHip - physiology
 
dc.subject.meshHip Injuries - drug therapy
 
dc.subject.meshOsseointegration
 
dc.subject.meshPolymethyl Methacrylate - toxicity
 
dc.subject.meshRabbits
 
dc.subject.meshWeight-Bearing
 
dc.subjectBioactive bone cement
 
dc.subjectInterface
 
dc.subjectMechanical property
 
dc.subjectNanoindentation
 
dc.subjectTotal hip arthroplasty
 
dc.titleNano-mechanics of bone and bioactive bone cement interfaces in a load-bearing model
 
dc.typeArticle
 
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Author Affiliations
  1. The University of Hong Kong