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Article: Nano-mechanics of bone and bioactive bone cement interfaces in a load-bearing model

TitleNano-mechanics of bone and bioactive bone cement interfaces in a load-bearing model
Authors
KeywordsBioactive bone cement
Interface
Mechanical property
Nanoindentation
Total hip arthroplasty
Issue Date2006
PublisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/biomaterials
Citation
Biomaterials, 2006, v. 27 n. 9, p. 1963-1970 How to Cite?
AbstractMany bioactive bone cements were developed for total hip replacement and found to bond with bone directly. However, the mechanical properties at the bone/bone cement interface under load bearing are not fully understood. In this study, a bioactive bone cement, which consists of strontium-containing hydroxyapatite (Sr-HA) powder and bisphenol-α-glycidyl dimethacrylate (Bis-GMA)-based resin, was evaluated in rabbit hip replacement for 6 months, and the mechanical properties of interfaces of cancellous bone/Sr-HA cement and cortical bone/Sr-HA cement were investigated by nanoindentation. The results showed that Young's modulus (17.6±4.2 GPa) and hardness (987.6±329.2 MPa) at interface between cancellous bone and Sr-HA cement were significantly higher than those at the cancellous bone (12.7±1.7 GPa; 632.7±108.4 MPa)and Sr-HA cement (5.2±0.5 GPa; 265.5±39.2 MPa); whereas Young's modulus (6.3±2.8 GPa) and hardness (417.4±164.5 MPa) at interface between cortical bone and Sr-HA cement were significantly lower than those at cortical bone(12.9±2.2 GPa; 887.9±162.0 MPa), but significantly higher than Sr-HA cement(3.6±0.3 GPa; 239.1±30.4 MPa). The results of the mechanical properties of the interfaces were supported by the histological observation and chemical composition. Osseointegration of Sr-HA cement with cancellous bone was observed. An apatite layer with high content of calcium and phosphorus was found between cancellous bone and Sr-HA cement. However, no such apatite layer was observed at the interface between cortical bone and Sr-HA cement. And the contents of calcium and phosphorus of the interface were lower than those of cortical bone. The mechanical properties indicated that these two interfaces were diffused interfaces, and cancellous bone or cortical bone was grown into Sr-HA cement 6 months after the implantation. © 2005 Elsevier Ltd. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/76162
ISSN
2014 Impact Factor: 8.557
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorNi, GXen_HK
dc.contributor.authorChoy, YSen_HK
dc.contributor.authorLu, WWen_HK
dc.contributor.authorNgan, AHWen_HK
dc.contributor.authorChiu, KYen_HK
dc.contributor.authorLi, ZYen_HK
dc.contributor.authorTang, Ben_HK
dc.contributor.authorLuk, KDKen_HK
dc.date.accessioned2010-09-06T07:18:14Z-
dc.date.available2010-09-06T07:18:14Z-
dc.date.issued2006en_HK
dc.identifier.citationBiomaterials, 2006, v. 27 n. 9, p. 1963-1970en_HK
dc.identifier.issn0142-9612en_HK
dc.identifier.urihttp://hdl.handle.net/10722/76162-
dc.description.abstractMany bioactive bone cements were developed for total hip replacement and found to bond with bone directly. However, the mechanical properties at the bone/bone cement interface under load bearing are not fully understood. In this study, a bioactive bone cement, which consists of strontium-containing hydroxyapatite (Sr-HA) powder and bisphenol-α-glycidyl dimethacrylate (Bis-GMA)-based resin, was evaluated in rabbit hip replacement for 6 months, and the mechanical properties of interfaces of cancellous bone/Sr-HA cement and cortical bone/Sr-HA cement were investigated by nanoindentation. The results showed that Young's modulus (17.6±4.2 GPa) and hardness (987.6±329.2 MPa) at interface between cancellous bone and Sr-HA cement were significantly higher than those at the cancellous bone (12.7±1.7 GPa; 632.7±108.4 MPa)and Sr-HA cement (5.2±0.5 GPa; 265.5±39.2 MPa); whereas Young's modulus (6.3±2.8 GPa) and hardness (417.4±164.5 MPa) at interface between cortical bone and Sr-HA cement were significantly lower than those at cortical bone(12.9±2.2 GPa; 887.9±162.0 MPa), but significantly higher than Sr-HA cement(3.6±0.3 GPa; 239.1±30.4 MPa). The results of the mechanical properties of the interfaces were supported by the histological observation and chemical composition. Osseointegration of Sr-HA cement with cancellous bone was observed. An apatite layer with high content of calcium and phosphorus was found between cancellous bone and Sr-HA cement. However, no such apatite layer was observed at the interface between cortical bone and Sr-HA cement. And the contents of calcium and phosphorus of the interface were lower than those of cortical bone. The mechanical properties indicated that these two interfaces were diffused interfaces, and cancellous bone or cortical bone was grown into Sr-HA cement 6 months after the implantation. © 2005 Elsevier Ltd. All rights reserved.en_HK
dc.languageengen_HK
dc.publisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/biomaterialsen_HK
dc.relation.ispartofBiomaterialsen_HK
dc.rightsBiomaterials . Copyright © Elsevier BV.en_HK
dc.subjectBioactive bone cementen_HK
dc.subjectInterfaceen_HK
dc.subjectMechanical propertyen_HK
dc.subjectNanoindentationen_HK
dc.subjectTotal hip arthroplastyen_HK
dc.subject.meshAnimalsen_HK
dc.subject.meshBone Cements - chemistry - therapeutic use - toxicityen_HK
dc.subject.meshBone and Bones - cytology - drug effects - physiologyen_HK
dc.subject.meshDurapatite - chemistry - therapeutic useen_HK
dc.subject.meshHip - physiologyen_HK
dc.subject.meshHip Injuries - drug therapyen_HK
dc.subject.meshOsseointegrationen_HK
dc.subject.meshPolymethyl Methacrylate - toxicityen_HK
dc.subject.meshRabbitsen_HK
dc.subject.meshWeight-Bearingen_HK
dc.titleNano-mechanics of bone and bioactive bone cement interfaces in a load-bearing modelen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0142-9612&volume=27&spage=1963&epage=1970&date=2006&atitle=Nano-mechanics+Of+Bone+And+Bioactive+Bone+Cement+Interfaces+In+A+Load-bearing+Modelen_HK
dc.identifier.emailLu, WW: wwlu@hku.hken_HK
dc.identifier.emailNgan, AHW: hwngan@hkucc.hku.hken_HK
dc.identifier.emailChiu, KY: pkychiu@hkucc.hku.hken_HK
dc.identifier.emailTang, B: tangbin@hkucc.hku.hken_HK
dc.identifier.emailLuk, KDK: hcm21000@hku.hken_HK
dc.identifier.authorityLu, WW=rp00411en_HK
dc.identifier.authorityNgan, AHW=rp00225en_HK
dc.identifier.authorityChiu, KY=rp00379en_HK
dc.identifier.authorityTang, B=rp00081en_HK
dc.identifier.authorityLuk, KDK=rp00333en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.biomaterials.2005.09.044en_HK
dc.identifier.pmid16226309en_HK
dc.identifier.scopuseid_2-s2.0-28744455189en_HK
dc.identifier.hkuros148556en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-28744455189&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume27en_HK
dc.identifier.issue9en_HK
dc.identifier.spage1963en_HK
dc.identifier.epage1970en_HK
dc.identifier.isiWOS:000234962500035-
dc.publisher.placeNetherlandsen_HK
dc.identifier.scopusauthoridNi, GX=8303037400en_HK
dc.identifier.scopusauthoridChoy, YS=36747493000en_HK
dc.identifier.scopusauthoridLu, WW=7404215221en_HK
dc.identifier.scopusauthoridNgan, AHW=7006827202en_HK
dc.identifier.scopusauthoridChiu, KY=7202988127en_HK
dc.identifier.scopusauthoridLi, ZY=35784563200en_HK
dc.identifier.scopusauthoridTang, B=24554184100en_HK
dc.identifier.scopusauthoridLuk, KDK=7201921573en_HK

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