Article: Nano-mechanics of bone and bioactive bone cement interfaces in a load-bearing model

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Publisher Website: 10.1016/j.biomaterials.2005.09.044
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PMID: 16226309
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Title	Nano-mechanics of bone and bioactive bone cement interfaces in a load-bearing model
Authors	Ni, GX1 Choy, YS1 Lu, WW1 Ngan, AHW1 Chiu, KY1 Li, ZY1 Tang, B1 Luk, KDK1
Keywords	Bioactive bone cement Interface Mechanical property Nanoindentation Total hip arthroplasty
Issue Date	2006
Publisher	Elsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/biomaterials
Citation	Biomaterials, 2006, v. 27 n. 9, p. 1963-1970 [How to Cite?] DOI: http://dx.doi.org/10.1016/j.biomaterials.2005.09.044
Abstract	Many bioactive bone cements were developed for total hip replacement and found to bond with bone directly. However, the mechanical properties at the bone/bone cement interface under load bearing are not fully understood. In this study, a bioactive bone cement, which consists of strontium-containing hydroxyapatite (Sr-HA) powder and bisphenol-α-glycidyl dimethacrylate (Bis-GMA)-based resin, was evaluated in rabbit hip replacement for 6 months, and the mechanical properties of interfaces of cancellous bone/Sr-HA cement and cortical bone/Sr-HA cement were investigated by nanoindentation. The results showed that Young's modulus (17.6±4.2 GPa) and hardness (987.6±329.2 MPa) at interface between cancellous bone and Sr-HA cement were significantly higher than those at the cancellous bone (12.7±1.7 GPa; 632.7±108.4 MPa)and Sr-HA cement (5.2±0.5 GPa; 265.5±39.2 MPa); whereas Young's modulus (6.3±2.8 GPa) and hardness (417.4±164.5 MPa) at interface between cortical bone and Sr-HA cement were significantly lower than those at cortical bone(12.9±2.2 GPa; 887.9±162.0 MPa), but significantly higher than Sr-HA cement(3.6±0.3 GPa; 239.1±30.4 MPa). The results of the mechanical properties of the interfaces were supported by the histological observation and chemical composition. Osseointegration of Sr-HA cement with cancellous bone was observed. An apatite layer with high content of calcium and phosphorus was found between cancellous bone and Sr-HA cement. However, no such apatite layer was observed at the interface between cortical bone and Sr-HA cement. And the contents of calcium and phosphorus of the interface were lower than those of cortical bone. The mechanical properties indicated that these two interfaces were diffused interfaces, and cancellous bone or cortical bone was grown into Sr-HA cement 6 months after the implantation. © 2005 Elsevier Ltd. All rights reserved.
ISSN	0142-9612 2011 Impact Factor: 7.404 2011 SCImago Journal Rankings: 0.633
DOI	http://dx.doi.org/10.1016/j.biomaterials.2005.09.044
ISI Accession Number ID	WOS:000234962500035
References	References in Scopus

DC Field	Value
dc.contributor.author	Ni, GX
dc.contributor.author	Choy, YS
dc.contributor.author	Lu, WW
dc.contributor.author	Ngan, AHW
dc.contributor.author	Chiu, KY
dc.contributor.author	Li, ZY
dc.contributor.author	Tang, B
dc.contributor.author	Luk, KDK
dc.date.accessioned	2010-09-06T07:18:14Z
dc.date.available	2010-09-06T07:18:14Z
dc.date.issued	2006
dc.description.abstract	Many bioactive bone cements were developed for total hip replacement and found to bond with bone directly. However, the mechanical properties at the bone/bone cement interface under load bearing are not fully understood. In this study, a bioactive bone cement, which consists of strontium-containing hydroxyapatite (Sr-HA) powder and bisphenol-α-glycidyl dimethacrylate (Bis-GMA)-based resin, was evaluated in rabbit hip replacement for 6 months, and the mechanical properties of interfaces of cancellous bone/Sr-HA cement and cortical bone/Sr-HA cement were investigated by nanoindentation. The results showed that Young's modulus (17.6±4.2 GPa) and hardness (987.6±329.2 MPa) at interface between cancellous bone and Sr-HA cement were significantly higher than those at the cancellous bone (12.7±1.7 GPa; 632.7±108.4 MPa)and Sr-HA cement (5.2±0.5 GPa; 265.5±39.2 MPa); whereas Young's modulus (6.3±2.8 GPa) and hardness (417.4±164.5 MPa) at interface between cortical bone and Sr-HA cement were significantly lower than those at cortical bone(12.9±2.2 GPa; 887.9±162.0 MPa), but significantly higher than Sr-HA cement(3.6±0.3 GPa; 239.1±30.4 MPa). The results of the mechanical properties of the interfaces were supported by the histological observation and chemical composition. Osseointegration of Sr-HA cement with cancellous bone was observed. An apatite layer with high content of calcium and phosphorus was found between cancellous bone and Sr-HA cement. However, no such apatite layer was observed at the interface between cortical bone and Sr-HA cement. And the contents of calcium and phosphorus of the interface were lower than those of cortical bone. The mechanical properties indicated that these two interfaces were diffused interfaces, and cancellous bone or cortical bone was grown into Sr-HA cement 6 months after the implantation. © 2005 Elsevier Ltd. All rights reserved.
dc.description.nature	Link_to_subscribed_fulltext
dc.identifier.citation	Biomaterials, 2006, v. 27 n. 9, p. 1963-1970 [How to Cite?] DOI: http://dx.doi.org/10.1016/j.biomaterials.2005.09.044
dc.identifier.doi	http://dx.doi.org/10.1016/j.biomaterials.2005.09.044
dc.identifier.epage	1970
dc.identifier.hkuros	148556
dc.identifier.isi	WOS:000234962500035
dc.identifier.issn	0142-9612 2011 Impact Factor: 7.404 2011 SCImago Journal Rankings: 0.633
dc.identifier.issue	9
dc.identifier.openurl
dc.identifier.pmid	16226309
dc.identifier.scopus	eid_2-s2.0-28744455189
dc.identifier.spage	1963
dc.identifier.uri	http://hdl.handle.net/10722/76162
dc.identifier.volume	27
dc.language	eng
dc.publisher	Elsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/biomaterials
dc.publisher.place	Netherlands
dc.relation.ispartof	Biomaterials
dc.relation.references	References in Scopus
dc.rights	Biomaterials . Copyright © Elsevier BV.
dc.subject.mesh	Animals
dc.subject.mesh	Bone Cements - chemistry - therapeutic use - toxicity
dc.subject.mesh	Bone and Bones - cytology - drug effects - physiology
dc.subject.mesh	Durapatite - chemistry - therapeutic use
dc.subject.mesh	Hip - physiology
dc.subject.mesh	Hip Injuries - drug therapy
dc.subject.mesh	Osseointegration
dc.subject.mesh	Polymethyl Methacrylate - toxicity
dc.subject.mesh	Rabbits
dc.subject.mesh	Weight-Bearing
dc.subject	Bioactive bone cement
dc.subject	Interface
dc.subject	Mechanical property
dc.subject	Nanoindentation
dc.subject	Total hip arthroplasty
dc.title	Nano-mechanics of bone and bioactive bone cement interfaces in a load-bearing model
dc.type	Article

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Article: Nano-mechanics of bone and bioactive bone cement interfaces in a load-bearing model

The HKU Scholars Hub has contact details for these author(s).