File Download

There are no files associated with this item.

  Links for fulltext
     (May Require Subscription)
Supplementary

Article: Supplementation-time dependence of growth factors in promoting tendon healing

TitleSupplementation-time dependence of growth factors in promoting tendon healing
Authors
Issue Date2006
PublisherLippincott Williams & Wilkins. The Journal's web site is located at http://www.corronline.com/
Citation
Clinical Orthopaedics And Related Research, 2006 n. 448, p. 240-247 How to Cite?
AbstractGrowth factors potentially promote tendon healing. Understanding the right time to administer growth factors and the dosage of growth factors are prerequisites for designing effective cytokine therapy. We investigated the supplementation-time dependence of the effects of platelet-derived growth factor isoform B at various dosages on tendon healing, and the temporal responsiveness of healing tendon toward platelet-derived growth factor. Platelet-derived growth factor isoform B at various dosages (0, 10, 100, or 1000 ng) was delivered into the gap wound of rat patellar tendons via microsyringe injection on Day 3 or Day 7 after injury. Tendon specimens were harvested on Day 14 for measurement of cell proliferation, pyridinoline content, and mechanical properties. We found increased proliferative response only when the growth factor was supplemented on Day 3 after injury, whereas supplementation on Day 7 resulted in greater peak load, cross-sectional area, and pyridinoline content. The ultimate stress did not change. Our findings suggest supplementation of platelet-derived growth factor isoform B at Day 7 benefits the mechanical properties and maturation of healing tendons. We also found platelet-derived growth factor receptor β expressing cells at the remodeling site as much as 6 months after injury, suggesting healing tendon also may be responsive to long-term delivery of platelet-derived growth factor. © 2006 Lippincott Williams & Wilkins.
Persistent Identifierhttp://hdl.handle.net/10722/76159
ISSN
2015 Impact Factor: 3.127
2015 SCImago Journal Rankings: 2.094
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorChan, BPen_HK
dc.contributor.authorFu, SCen_HK
dc.contributor.authorQin, Len_HK
dc.contributor.authorRolf, Cen_HK
dc.contributor.authorChan, KMen_HK
dc.date.accessioned2010-09-06T07:18:12Z-
dc.date.available2010-09-06T07:18:12Z-
dc.date.issued2006en_HK
dc.identifier.citationClinical Orthopaedics And Related Research, 2006 n. 448, p. 240-247en_HK
dc.identifier.issn0009-921Xen_HK
dc.identifier.urihttp://hdl.handle.net/10722/76159-
dc.description.abstractGrowth factors potentially promote tendon healing. Understanding the right time to administer growth factors and the dosage of growth factors are prerequisites for designing effective cytokine therapy. We investigated the supplementation-time dependence of the effects of platelet-derived growth factor isoform B at various dosages on tendon healing, and the temporal responsiveness of healing tendon toward platelet-derived growth factor. Platelet-derived growth factor isoform B at various dosages (0, 10, 100, or 1000 ng) was delivered into the gap wound of rat patellar tendons via microsyringe injection on Day 3 or Day 7 after injury. Tendon specimens were harvested on Day 14 for measurement of cell proliferation, pyridinoline content, and mechanical properties. We found increased proliferative response only when the growth factor was supplemented on Day 3 after injury, whereas supplementation on Day 7 resulted in greater peak load, cross-sectional area, and pyridinoline content. The ultimate stress did not change. Our findings suggest supplementation of platelet-derived growth factor isoform B at Day 7 benefits the mechanical properties and maturation of healing tendons. We also found platelet-derived growth factor receptor β expressing cells at the remodeling site as much as 6 months after injury, suggesting healing tendon also may be responsive to long-term delivery of platelet-derived growth factor. © 2006 Lippincott Williams & Wilkins.en_HK
dc.languageengen_HK
dc.publisherLippincott Williams & Wilkins. The Journal's web site is located at http://www.corronline.com/en_HK
dc.relation.ispartofClinical Orthopaedics and Related Researchen_HK
dc.rightsClinical Orthopaedics and Related Research. Copyright © Lippincott Williams & Wilkins.en_HK
dc.titleSupplementation-time dependence of growth factors in promoting tendon healingen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0009-921X&volume=448&spage=240&epage=247.&date=2006&atitle=Supplementation-time+dependence+of+growth+factors+in+promoting+tendon+healingen_HK
dc.identifier.emailChan, BP:bpchan@hkucc.hku.hken_HK
dc.identifier.authorityChan, BP=rp00087en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1097/01.blo.0000205875.97468.e4en_HK
dc.identifier.scopuseid_2-s2.0-33746902029en_HK
dc.identifier.hkuros137936en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-33746902029&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.issue448en_HK
dc.identifier.spage240en_HK
dc.identifier.epage247en_HK
dc.identifier.isiWOS:000243020700035-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridChan, BP=7201530390en_HK
dc.identifier.scopusauthoridFu, SC=7402732268en_HK
dc.identifier.scopusauthoridQin, L=24449633900en_HK
dc.identifier.scopusauthoridRolf, C=8558587900en_HK
dc.identifier.scopusauthoridChan, KM=7406034671en_HK

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats