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Article: Mathematical modeling of guided neurite extension in an engineered conduit with multiple concentration gradients of Nerve Growth Factor (NGF)

TitleMathematical modeling of guided neurite extension in an engineered conduit with multiple concentration gradients of Nerve Growth Factor (NGF)
Authors
KeywordsConcentration gradient
Conduit design
Guided growth
Nerve regeneration
NGF
PC12 cells
Issue Date2007
PublisherSpringer New York LLC. The Journal's web site is located at http://springerlink.metapress.com/openurl.asp?genre=journal&issn=0090-6964
Citation
Annals Of Biomedical Engineering, 2007, v. 35 n. 9, p. 1561-1572 How to Cite?
AbstractNeurotrophic factors such as nerve growth factor (NGF) provide essential cues to navigate growing axon toward their targets. Concentration and concentration gradient of NGF are key parameters affecting the growth rate and direction of neurites and axons. However, the maximum distance for guided nerve growth under stimulation of a single concentration gradient is limited and is thus unfavorable in nerve regeneration. Since the sensitivity of PC12 cells to NGF signals is restorable even after brief removal of the factors, exposure to multiple concentration gradients of the factor can achieve longer distances and greater rates of guided growth. In this study, a mathematical model simulating nerve growth in a virtually constructed nerve conduit incorporating multiple NGF concentration gradients is established. Using a genetic algorithm, optimized initial profiles of NGF able to achieve 4.5 cm of guided growth with a significantly improved growth rate has been obtained. The model also predicts an inverse relationship between the diffusion coefficient of the factor and the neurite growth rate. This model provides a useful tool for evaluating various conduit designs before fabrication and evaluation. © 2007 Biomedical Engineering Society.
Persistent Identifierhttp://hdl.handle.net/10722/76096
ISSN
2015 Impact Factor: 2.887
2015 SCImago Journal Rankings: 1.182
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorTse, THZen_HK
dc.contributor.authorChan, BPen_HK
dc.contributor.authorChan, CMen_HK
dc.contributor.authorLam, Jen_HK
dc.date.accessioned2010-09-06T07:17:36Z-
dc.date.available2010-09-06T07:17:36Z-
dc.date.issued2007en_HK
dc.identifier.citationAnnals Of Biomedical Engineering, 2007, v. 35 n. 9, p. 1561-1572en_HK
dc.identifier.issn0090-6964en_HK
dc.identifier.urihttp://hdl.handle.net/10722/76096-
dc.description.abstractNeurotrophic factors such as nerve growth factor (NGF) provide essential cues to navigate growing axon toward their targets. Concentration and concentration gradient of NGF are key parameters affecting the growth rate and direction of neurites and axons. However, the maximum distance for guided nerve growth under stimulation of a single concentration gradient is limited and is thus unfavorable in nerve regeneration. Since the sensitivity of PC12 cells to NGF signals is restorable even after brief removal of the factors, exposure to multiple concentration gradients of the factor can achieve longer distances and greater rates of guided growth. In this study, a mathematical model simulating nerve growth in a virtually constructed nerve conduit incorporating multiple NGF concentration gradients is established. Using a genetic algorithm, optimized initial profiles of NGF able to achieve 4.5 cm of guided growth with a significantly improved growth rate has been obtained. The model also predicts an inverse relationship between the diffusion coefficient of the factor and the neurite growth rate. This model provides a useful tool for evaluating various conduit designs before fabrication and evaluation. © 2007 Biomedical Engineering Society.en_HK
dc.languageengen_HK
dc.publisherSpringer New York LLC. The Journal's web site is located at http://springerlink.metapress.com/openurl.asp?genre=journal&issn=0090-6964en_HK
dc.relation.ispartofAnnals of Biomedical Engineeringen_HK
dc.subjectConcentration gradienten_HK
dc.subjectConduit designen_HK
dc.subjectGuided growthen_HK
dc.subjectNerve regenerationen_HK
dc.subjectNGFen_HK
dc.subjectPC12 cellsen_HK
dc.titleMathematical modeling of guided neurite extension in an engineered conduit with multiple concentration gradients of Nerve Growth Factor (NGF)en_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0090-6964&volume=35&issue=9&spage=1561&epage=1572.&date=2007&atitle=Mathematical+modeling+of+guided+neurite+growth+in+an+engineered+conduit+with+multiple+concentration+gradients+of+nerve+growth+factor+(NGF)en_HK
dc.identifier.emailChan, BP:bpchan@hkucc.hku.hken_HK
dc.identifier.authorityChan, BP=rp00087en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1007/s10439-007-9328-4en_HK
dc.identifier.pmid17520368-
dc.identifier.scopuseid_2-s2.0-35248848917en_HK
dc.identifier.hkuros137703en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-35248848917&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume35en_HK
dc.identifier.issue9en_HK
dc.identifier.spage1561en_HK
dc.identifier.epage1572en_HK
dc.identifier.isiWOS:000248823800008-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridTse, THZ=35228346700en_HK
dc.identifier.scopusauthoridChan, BP=7201530390en_HK
dc.identifier.scopusauthoridChan, CM=7404814453en_HK
dc.identifier.scopusauthoridLam, J=25923453500en_HK

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