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Article: Selective laser sintering of porous tissue engineering scaffolds from poly(L-lactide)/carbonated hydroxyapatite nanocomposite microspheres

TitleSelective laser sintering of porous tissue engineering scaffolds from poly(L-lactide)/carbonated hydroxyapatite nanocomposite microspheres
Authors
Issue Date2008
PublisherSpringer New York LLC. The Journal's web site is located at http://springerlink.metapress.com/openurl.asp?genre=journal&issn=0957-4530
Citation
Journal Of Materials Science: Materials In Medicine, 2008, v. 19 n. 7, p. 2535-2540 How to Cite?
AbstractThis study focuses on the use of bio-nanocomposite microspheres, consisting of carbonated hydroxyapatite (CHAp) nanospheres within a poly(L-lactide) (PLLA) matrix, to produce tissue engineering (TE) scaffolds using a modified selective laser sintering (SLS) machine. PLLA microspheres and PLLA/CHAp nanocomposite microspheres were prepared by emulsion techniques. The resultant microspheres had a size range of 5-30 μm, suitable for the SLS process. Microstructural analyses revealed that the CHAp nanospheres were embedded throughout the PLLA microsphere, forming a nanocomposite structure. A custom-made miniature sintering platform was installed in a commercial Sinterstation® 2000 SLS machine. This platform allowed the use of small quantities of biomaterials for TE scaffold production. The effects of laser power; scan spacing and part bed temperature were investigated and optimized. Finally, porous scaffolds were successfully fabricated from the PLLA microspheres and PLLA/CHAp nanocomposite microspheres. In particular, the PLLA/CHAp nanocomposite microspheres appeared to be promising for porous bone TE scaffold production using the SLS technique. © Springer Science+Business Media, LLC 2007.
Persistent Identifierhttp://hdl.handle.net/10722/76089
ISSN
2015 Impact Factor: 2.272
2013 SCImago Journal Rankings: 0.897
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorZhou, WYen_HK
dc.contributor.authorLee, SHen_HK
dc.contributor.authorWang, Men_HK
dc.contributor.authorCheung, WLen_HK
dc.contributor.authorIp, WYen_HK
dc.date.accessioned2010-09-06T07:17:32Z-
dc.date.available2010-09-06T07:17:32Z-
dc.date.issued2008en_HK
dc.identifier.citationJournal Of Materials Science: Materials In Medicine, 2008, v. 19 n. 7, p. 2535-2540en_HK
dc.identifier.issn0957-4530en_HK
dc.identifier.urihttp://hdl.handle.net/10722/76089-
dc.description.abstractThis study focuses on the use of bio-nanocomposite microspheres, consisting of carbonated hydroxyapatite (CHAp) nanospheres within a poly(L-lactide) (PLLA) matrix, to produce tissue engineering (TE) scaffolds using a modified selective laser sintering (SLS) machine. PLLA microspheres and PLLA/CHAp nanocomposite microspheres were prepared by emulsion techniques. The resultant microspheres had a size range of 5-30 μm, suitable for the SLS process. Microstructural analyses revealed that the CHAp nanospheres were embedded throughout the PLLA microsphere, forming a nanocomposite structure. A custom-made miniature sintering platform was installed in a commercial Sinterstation® 2000 SLS machine. This platform allowed the use of small quantities of biomaterials for TE scaffold production. The effects of laser power; scan spacing and part bed temperature were investigated and optimized. Finally, porous scaffolds were successfully fabricated from the PLLA microspheres and PLLA/CHAp nanocomposite microspheres. In particular, the PLLA/CHAp nanocomposite microspheres appeared to be promising for porous bone TE scaffold production using the SLS technique. © Springer Science+Business Media, LLC 2007.en_HK
dc.languageengen_HK
dc.publisherSpringer New York LLC. The Journal's web site is located at http://springerlink.metapress.com/openurl.asp?genre=journal&issn=0957-4530en_HK
dc.relation.ispartofJournal of Materials Science: Materials in Medicineen_HK
dc.rightsThe original publication is available at www.springerlink.com-
dc.subject.meshBone Substitutes - chemistry-
dc.subject.meshHydroxyapatites - chemistry - radiation effects-
dc.subject.meshNanostructures - chemistry - radiation effects - ultrastructure-
dc.subject.meshPolyesters - chemistry-
dc.subject.meshTissue Engineering - methods-
dc.titleSelective laser sintering of porous tissue engineering scaffolds from poly(L-lactide)/carbonated hydroxyapatite nanocomposite microspheresen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0957-4530&volume=19&issue=7&spage=2535&epage=2540&date=2008&atitle=Selective+laser+sintering+of+porous+tissue+engineering+scaffolds+from+poly(L-lactide)/carbonated+hydroxyapatite+nanocomposite+microspheresen_HK
dc.identifier.emailWang, M:memwang@hku.hken_HK
dc.identifier.emailCheung, WL:wlcheung@hkucc.hku.hken_HK
dc.identifier.emailIp, WY:wyip@hku.hken_HK
dc.identifier.authorityWang, M=rp00185en_HK
dc.identifier.authorityCheung, WL=rp00103en_HK
dc.identifier.authorityIp, WY=rp00401en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1007/s10856-007-3089-3en_HK
dc.identifier.pmid17619975-
dc.identifier.scopuseid_2-s2.0-72949101766en_HK
dc.identifier.hkuros143318en_HK
dc.identifier.hkuros179460-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-72949101766&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume19en_HK
dc.identifier.issue7en_HK
dc.identifier.spage2535en_HK
dc.identifier.epage2540en_HK
dc.identifier.isiWOS:000255879100002-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridZhou, WY=26636766600en_HK
dc.identifier.scopusauthoridLee, SH=36802151400en_HK
dc.identifier.scopusauthoridWang, M=15749714100en_HK
dc.identifier.scopusauthoridCheung, WL=7202743084en_HK
dc.identifier.scopusauthoridIp, WY=35549641700en_HK

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