File Download

There are no files associated with this item.

  Links for fulltext
     (May Require Subscription)
Supplementary

Article: The roles of bone morphogenetic protein (BMP) 12 in stimulating the proliferation and matrix production of human patellar tendon fibroblasts

TitleThe roles of bone morphogenetic protein (BMP) 12 in stimulating the proliferation and matrix production of human patellar tendon fibroblasts
Authors
Issue Date2003
PublisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/lifescie
Citation
Life Sciences, 2003, v. 72 n. 26, p. 2965-2974 How to Cite?
AbstractRecombinant human (rh) bone morphogenetic protein 12 (BMP12) is proved to induce the formation of tendon and ligament tissues in animal experiments. But the roles of BMP12 on tissue regeneration in human tendons remain unexplored. In the present study, healthy human patellar tendon samples were collected for histological examination and preparation of tendon fibroblast culture. Immunohistochemical staining showed that BMP12 was detected on healthy patellar tendon samples, only located on active tenoblasts and perivascular mesenchymal cells but not in interstitial tenocytes. The expression of PCNA and procollagen type I also exhibited a similar distribution. It indicates that BMP12 may be involved in matrix remodeling process in adult tissues. In vitro studies showed that rhBMP12 could increase proliferation of tendon fibroblasts and increase the gene expression of procollagen type I and type III, but decrease the gene expression of decorin in tendon fibroblasts culture. Our findings suggest that BMP12 may play a role in early phases of tissue regeneration in tendons. © 2003 Published by Elsevier Science Inc.
Persistent Identifierhttp://hdl.handle.net/10722/76049
ISSN
2015 Impact Factor: 2.685
2015 SCImago Journal Rankings: 1.056
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorFu, SCen_HK
dc.contributor.authorWong, YPen_HK
dc.contributor.authorChan, BPen_HK
dc.contributor.authorPau, HMen_HK
dc.contributor.authorCheuk, YCen_HK
dc.contributor.authorLee, KMen_HK
dc.contributor.authorChan, KMen_HK
dc.date.accessioned2010-09-06T07:17:07Z-
dc.date.available2010-09-06T07:17:07Z-
dc.date.issued2003en_HK
dc.identifier.citationLife Sciences, 2003, v. 72 n. 26, p. 2965-2974en_HK
dc.identifier.issn0024-3205en_HK
dc.identifier.urihttp://hdl.handle.net/10722/76049-
dc.description.abstractRecombinant human (rh) bone morphogenetic protein 12 (BMP12) is proved to induce the formation of tendon and ligament tissues in animal experiments. But the roles of BMP12 on tissue regeneration in human tendons remain unexplored. In the present study, healthy human patellar tendon samples were collected for histological examination and preparation of tendon fibroblast culture. Immunohistochemical staining showed that BMP12 was detected on healthy patellar tendon samples, only located on active tenoblasts and perivascular mesenchymal cells but not in interstitial tenocytes. The expression of PCNA and procollagen type I also exhibited a similar distribution. It indicates that BMP12 may be involved in matrix remodeling process in adult tissues. In vitro studies showed that rhBMP12 could increase proliferation of tendon fibroblasts and increase the gene expression of procollagen type I and type III, but decrease the gene expression of decorin in tendon fibroblasts culture. Our findings suggest that BMP12 may play a role in early phases of tissue regeneration in tendons. © 2003 Published by Elsevier Science Inc.en_HK
dc.languageengen_HK
dc.publisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/lifescieen_HK
dc.relation.ispartofLife Sciencesen_HK
dc.subject.meshAdolescenten_HK
dc.subject.meshAdulten_HK
dc.subject.meshBiglycanen_HK
dc.subject.meshBone Morphogenetic Proteins - genetics - metabolismen_HK
dc.subject.meshCell Division - physiologyen_HK
dc.subject.meshCells, Cultureden_HK
dc.subject.meshDecorinen_HK
dc.subject.meshExtracellular Matrix - metabolismen_HK
dc.subject.meshExtracellular Matrix Proteinsen_HK
dc.subject.meshFemaleen_HK
dc.subject.meshFibroblasts - cytology - physiologyen_HK
dc.subject.meshGrowth Differentiation Factorsen_HK
dc.subject.meshHumansen_HK
dc.subject.meshMaleen_HK
dc.subject.meshPatellar Ligament - cytology - metabolismen_HK
dc.subject.meshProcollagen - genetics - metabolismen_HK
dc.subject.meshProliferating Cell Nuclear Antigen - metabolismen_HK
dc.subject.meshProteoglycans - genetics - metabolismen_HK
dc.subject.meshRecombinant Proteins - genetics - metabolismen_HK
dc.subject.meshTransforming Growth Factor betaen_HK
dc.titleThe roles of bone morphogenetic protein (BMP) 12 in stimulating the proliferation and matrix production of human patellar tendon fibroblastsen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0885-1573&volume=72&issue=26&spage=2965&epage=2974.&date=2003&atitle=The+roles+of+bone+morphogenetic+protein+(BMP)+12+in+stimulating+the+proliferation+and+matrix+production+of+human+patellar+tendon+fibroblastsen_HK
dc.identifier.emailChan, BP:bpchan@hkucc.hku.hken_HK
dc.identifier.authorityChan, BP=rp00087en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/S0024-3205(03)00169-3en_HK
dc.identifier.pmid12706484-
dc.identifier.scopuseid_2-s2.0-0037449101en_HK
dc.identifier.hkuros89220en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0037449101&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume72en_HK
dc.identifier.issue26en_HK
dc.identifier.spage2965en_HK
dc.identifier.epage2974en_HK
dc.identifier.isiWOS:000182522400004-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridFu, SC=7402732268en_HK
dc.identifier.scopusauthoridWong, YP=36853080700en_HK
dc.identifier.scopusauthoridChan, BP=7201530390en_HK
dc.identifier.scopusauthoridPau, HM=7102371880en_HK
dc.identifier.scopusauthoridCheuk, YC=6506267931en_HK
dc.identifier.scopusauthoridLee, KM=35327196100en_HK
dc.identifier.scopusauthoridChan, KM=7406034671en_HK

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats