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Article: PLLA scaffolds with biomimetic apatite coating and biomimetic apatite/collagen composite coating to enhance osteoblast-like cells attachment and activity

TitlePLLA scaffolds with biomimetic apatite coating and biomimetic apatite/collagen composite coating to enhance osteoblast-like cells attachment and activity
Authors
KeywordsApatite
Bone tissue engineering
Cell culture
Collagen
Osteoblast
Polylactic acid
Issue Date2006
PublisherElsevier SA. The Journal's web site is located at http://www.elsevier.com/locate/surfcoat
Citation
Surface And Coatings Technology, 2006, v. 201 n. 3-4, p. 575-580 How to Cite?
AbstractNovel scaffolds composed of poly(l-lactic acid) (PLLA) skeleton covered with bonelike apatite or apatite/collagen composite were produced via a combined phase-separation technique and an accelerated biomimetic coating process. Saos-2 osteoblast-like cells were used to evaluate the cellular behaviors on these biomimetic coatings. Cell morphologies on the surfaces of PLLA scaffolds, PLLA scaffolds with apatite coating, and PLLA scaffolds with apatite/collagen composite coating were studied by scanning electron microscopy (SEM). Cell viability was assessed by the MTT assay. Differentiated osteoblastic function was monitored by measuring alkaline phosphatase activity. These results suggested that the apatite coating and apatite/collagen composite coating generated through the accelerated biomimetic processes could improve the interactions between osteoblasts and the polymeric scaffolds. The apatite/collagen composite coating was more effective than apatite coating in improving such interactions. The PLLA scaffold with apatite/collagen composite coating is promising as a candidate 3D substrate for bone tissue engineering. © 2005 Elsevier B.V. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/75957
ISSN
2015 Impact Factor: 2.139
2015 SCImago Journal Rankings: 0.872
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorChen, Yen_HK
dc.contributor.authorMak, AFTen_HK
dc.contributor.authorWang, Men_HK
dc.contributor.authorLi, Jen_HK
dc.contributor.authorWong, MSen_HK
dc.date.accessioned2010-09-06T07:16:12Z-
dc.date.available2010-09-06T07:16:12Z-
dc.date.issued2006en_HK
dc.identifier.citationSurface And Coatings Technology, 2006, v. 201 n. 3-4, p. 575-580en_HK
dc.identifier.issn0257-8972en_HK
dc.identifier.urihttp://hdl.handle.net/10722/75957-
dc.description.abstractNovel scaffolds composed of poly(l-lactic acid) (PLLA) skeleton covered with bonelike apatite or apatite/collagen composite were produced via a combined phase-separation technique and an accelerated biomimetic coating process. Saos-2 osteoblast-like cells were used to evaluate the cellular behaviors on these biomimetic coatings. Cell morphologies on the surfaces of PLLA scaffolds, PLLA scaffolds with apatite coating, and PLLA scaffolds with apatite/collagen composite coating were studied by scanning electron microscopy (SEM). Cell viability was assessed by the MTT assay. Differentiated osteoblastic function was monitored by measuring alkaline phosphatase activity. These results suggested that the apatite coating and apatite/collagen composite coating generated through the accelerated biomimetic processes could improve the interactions between osteoblasts and the polymeric scaffolds. The apatite/collagen composite coating was more effective than apatite coating in improving such interactions. The PLLA scaffold with apatite/collagen composite coating is promising as a candidate 3D substrate for bone tissue engineering. © 2005 Elsevier B.V. All rights reserved.en_HK
dc.languageengen_HK
dc.publisherElsevier SA. The Journal's web site is located at http://www.elsevier.com/locate/surfcoaten_HK
dc.relation.ispartofSurface and Coatings Technologyen_HK
dc.subjectApatiteen_HK
dc.subjectBone tissue engineeringen_HK
dc.subjectCell cultureen_HK
dc.subjectCollagenen_HK
dc.subjectOsteoblasten_HK
dc.subjectPolylactic aciden_HK
dc.titlePLLA scaffolds with biomimetic apatite coating and biomimetic apatite/collagen composite coating to enhance osteoblast-like cells attachment and activityen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0257-8972&volume=201&spage=575&epage=580&date=2006&atitle=PLLA+scaffolds+with+biomimetic+apatite+coating+and+biomimetic+apatite/collagen+composite+coating+to+enhance+osteoblast-like+cells+attachment+and+activityen_HK
dc.identifier.emailWang, M:memwang@hku.hken_HK
dc.identifier.authorityWang, M=rp00185en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.surfcoat.2005.12.005en_HK
dc.identifier.scopuseid_2-s2.0-33748425111en_HK
dc.identifier.hkuros132973en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-33748425111&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume201en_HK
dc.identifier.issue3-4en_HK
dc.identifier.spage575en_HK
dc.identifier.epage580en_HK
dc.identifier.isiWOS:000244477300010-
dc.publisher.placeSwitzerlanden_HK
dc.identifier.scopusauthoridChen, Y=8643007600en_HK
dc.identifier.scopusauthoridMak, AFT=35516744100en_HK
dc.identifier.scopusauthoridWang, M=15749714100en_HK
dc.identifier.scopusauthoridLi, J=7410064873en_HK
dc.identifier.scopusauthoridWong, MS=23394345200en_HK

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