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Article: Immunomodulating effects of CKBM on the cytokine production in peripheral blood mononuclear cells (PBMCs) from healthy volunteers

TitleImmunomodulating effects of CKBM on the cytokine production in peripheral blood mononuclear cells (PBMCs) from healthy volunteers
Authors
Chan, BPYuen, WFLee, WHWong, SNChung, TYWu, YJPang, SF
KeywordsCytokine
Immunomodulation
PBMCs
Issue Date2004
PublisherInforma Healthcare. The Journal's web site is located at http://www.tandf.co.uk/journals/titles/08923973.asp
Citation
Immunopharmacology And Immunotoxicology, 2004, v. 26 n. 2, p. 177-192 How to Cite?
DOI: http://dx.doi.org/10.1081/IPH-120037713
AbstractThe current study investigated the immunomodulating effect of CKBM on cytokine induction in peripheral blood mononuclear cells (PBMCs) isolated from 20 healthy volunteers. Cytometric Bead Analysis (CBA) was used to study IL-2, IL-4, IL-6, IL-10, TNF-alpha and IFN-gamma. TNF-alpha and IL-6 were significantly increased in a CKBM dose- and time-dependent-manner. Flow cytometry analysis showed an increased intracellular staining of IL-6 but not of TNF-alpha in CKBM treated PBMCs. In addition, MTT cell cytotoxicity assay showed that CKBM concentrations below 5% did not significantly affect the metabolic activities of PBMCs. The current study indicated that CKBM may modulate the immune response by inducing the secretions of TNF-alpha and IL-6, which are cytokine mediators of innate immunity and inflammation preparing or "priming" the body to combat diseases.
Persistent Identifierhttp://hdl.handle.net/10722/75925
ISSN
0892-3973
2023 Impact Factor: 2.9
2023 SCImago Journal Rankings: 0.680
ISI Accession Number ID
WOS:000221946600002
References
References in Scopus

 

DC FieldValueLanguage
dc.contributor.authorChan, BPen_HK
dc.contributor.authorYuen, WFen_HK
dc.contributor.authorLee, WHen_HK
dc.contributor.authorWong, SNen_HK
dc.contributor.authorChung, TYen_HK
dc.contributor.authorWu, YJen_HK
dc.contributor.authorPang, SFen_HK
dc.date.accessioned2010-09-06T07:15:54Z-
dc.date.available2010-09-06T07:15:54Z-
dc.date.issued2004en_HK
dc.identifier.citationImmunopharmacology And Immunotoxicology, 2004, v. 26 n. 2, p. 177-192en_HK
dc.identifier.issn0892-3973en_HK
dc.identifier.urihttp://hdl.handle.net/10722/75925-
dc.description.abstractThe current study investigated the immunomodulating effect of CKBM on cytokine induction in peripheral blood mononuclear cells (PBMCs) isolated from 20 healthy volunteers. Cytometric Bead Analysis (CBA) was used to study IL-2, IL-4, IL-6, IL-10, TNF-alpha and IFN-gamma. TNF-alpha and IL-6 were significantly increased in a CKBM dose- and time-dependent-manner. Flow cytometry analysis showed an increased intracellular staining of IL-6 but not of TNF-alpha in CKBM treated PBMCs. In addition, MTT cell cytotoxicity assay showed that CKBM concentrations below 5% did not significantly affect the metabolic activities of PBMCs. The current study indicated that CKBM may modulate the immune response by inducing the secretions of TNF-alpha and IL-6, which are cytokine mediators of innate immunity and inflammation preparing or "priming" the body to combat diseases.en_HK
dc.languageengen_HK
dc.publisherInforma Healthcare. The Journal's web site is located at http://www.tandf.co.uk/journals/titles/08923973.aspen_HK
dc.relation.ispartofImmunopharmacology and Immunotoxicologyen_HK
dc.rightsImmunopharmacology and Immunotoxicology. Copyright © Informa Healthcare.en_HK
dc.subjectCytokine-
dc.subjectImmunomodulation-
dc.subjectPBMCs-
dc.subject.meshAdulten_HK
dc.subject.meshCell Survival - drug effectsen_HK
dc.subject.meshCytokines - biosynthesisen_HK
dc.subject.meshDose-Response Relationship, Drugen_HK
dc.subject.meshFemaleen_HK
dc.subject.meshHumansen_HK
dc.subject.meshImmunologic Factors - administration & dosage - pharmacology - toxicityen_HK
dc.subject.meshInterferon-gamma - biosynthesisen_HK
dc.subject.meshInterleukin-6 - biosynthesisen_HK
dc.subject.meshLeukocytes, Mononuclear - drug effects - immunologyen_HK
dc.subject.meshMaleen_HK
dc.subject.meshMiddle Ageden_HK
dc.subject.meshPlant Extracts - administration & dosage - pharmacology - toxicityen_HK
dc.subject.meshReceptors, Tumor Necrosis Factor, Type II - biosynthesisen_HK
dc.subject.meshTumor Necrosis Factor-alpha - biosynthesisen_HK
dc.titleImmunomodulating effects of CKBM on the cytokine production in peripheral blood mononuclear cells (PBMCs) from healthy volunteersen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0892-3973&volume=26&issue=2&spage=177&epage=192.&date=2004&atitle=Immunomodulating+effects+of+CKBM+on+the+cytokine+production+in+peripheral+blood+mononuclear+cells+(PBMCs)+from+healthy+volunteersen_HK
dc.identifier.emailChan, BP:bpchan@hkucc.hku.hken_HK
dc.identifier.authorityChan, BP=rp00087en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1081/IPH-120037713en_HK
dc.identifier.pmid15209354-
dc.identifier.scopuseid_2-s2.0-2942575796en_HK
dc.identifier.hkuros89217en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-2942575796&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume26en_HK
dc.identifier.issue2en_HK
dc.identifier.spage177en_HK
dc.identifier.epage192en_HK
dc.identifier.isiWOS:000221946600002-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridChan, BP=7201530390en_HK
dc.identifier.scopusauthoridYuen, WF=24342315300en_HK
dc.identifier.scopusauthoridLee, WH=7407088440en_HK
dc.identifier.scopusauthoridWong, SN=7404590305en_HK
dc.identifier.scopusauthoridChung, TY=7401571262en_HK
dc.identifier.scopusauthoridWu, YJ=7406893661en_HK
dc.identifier.scopusauthoridPang, SF=7402528719en_HK
dc.identifier.issnl0892-3973-

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