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Article: Photochemical repair of Achilles tendon rupture in a rat model

TitlePhotochemical repair of Achilles tendon rupture in a rat model
Authors
Issue Date2005
PublisherElsevier Inc.. The Journal's web site is located at http://www.elsevier.com/locate/jsre
Citation
Journal Of Surgical Research, 2005, v. 124 n. 2, p. 274-279 How to Cite?
AbstractBackground. Photochemical tissue bonding (PTB) is an emerging technique for bonding or sealing tissue surfaces that requires light and a photoactive dye for its effect. The potential of PTB for tendon repair was assessed in a rat model. Materials and methods. The optical properties of bovine tendon were determined ex vivo to gauge the depth of light penetration as a function of wavelength and dosimetry parameters were established for PTB repair of ruptured tendon. PTB was then tested in vivo to repair transected tendons in Sprague-Dawley rats. Repair strengths were measured using a strain gauge up to 14 days post treatment. Results. The effective penetration depth in tendon was estimated to be 0.68 mm at 514 nm. Following PTB treatment of mechanically ruptured tendon, significant bonding was dependent on the presence of both light and dye and attained a plateau strength at a fluence of 125 J/cm 2. In a subsequent in vivo study to investigate PTB for repair of transected rat Achilles tendon, the ultimate stress required to break the repaired tendon was measured immediately after irradiation and at 7 and 14 days post-repair. Results showed that the difference in the ultimate stress between control and PTB treatment groups was statistically significant immediately after treatment and at 7 days (p = 0.04) but not 14 days (p = 0.75) post-repair. Conclusions. PTB provides a benefit to tendon repair at early stages in repair and is worthy of further investigation as a potential surgical adjunct for tendon repair in orthopedic surgeries. © 2005 Elsevier Inc. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/75639
ISSN
2015 Impact Factor: 2.198
2015 SCImago Journal Rankings: 0.928
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorChan, BPen_HK
dc.contributor.authorAmann, Cen_HK
dc.contributor.authorYaroslavsky, ANen_HK
dc.contributor.authorTitle, Cen_HK
dc.contributor.authorSmink, Den_HK
dc.contributor.authorZarins, Ben_HK
dc.contributor.authorKochevar, IEen_HK
dc.contributor.authorRedmond, RWen_HK
dc.date.accessioned2010-09-06T07:13:08Z-
dc.date.available2010-09-06T07:13:08Z-
dc.date.issued2005en_HK
dc.identifier.citationJournal Of Surgical Research, 2005, v. 124 n. 2, p. 274-279en_HK
dc.identifier.issn0022-4804en_HK
dc.identifier.urihttp://hdl.handle.net/10722/75639-
dc.description.abstractBackground. Photochemical tissue bonding (PTB) is an emerging technique for bonding or sealing tissue surfaces that requires light and a photoactive dye for its effect. The potential of PTB for tendon repair was assessed in a rat model. Materials and methods. The optical properties of bovine tendon were determined ex vivo to gauge the depth of light penetration as a function of wavelength and dosimetry parameters were established for PTB repair of ruptured tendon. PTB was then tested in vivo to repair transected tendons in Sprague-Dawley rats. Repair strengths were measured using a strain gauge up to 14 days post treatment. Results. The effective penetration depth in tendon was estimated to be 0.68 mm at 514 nm. Following PTB treatment of mechanically ruptured tendon, significant bonding was dependent on the presence of both light and dye and attained a plateau strength at a fluence of 125 J/cm 2. In a subsequent in vivo study to investigate PTB for repair of transected rat Achilles tendon, the ultimate stress required to break the repaired tendon was measured immediately after irradiation and at 7 and 14 days post-repair. Results showed that the difference in the ultimate stress between control and PTB treatment groups was statistically significant immediately after treatment and at 7 days (p = 0.04) but not 14 days (p = 0.75) post-repair. Conclusions. PTB provides a benefit to tendon repair at early stages in repair and is worthy of further investigation as a potential surgical adjunct for tendon repair in orthopedic surgeries. © 2005 Elsevier Inc. All rights reserved.en_HK
dc.languageengen_HK
dc.publisherElsevier Inc.. The Journal's web site is located at http://www.elsevier.com/locate/jsreen_HK
dc.relation.ispartofJournal of Surgical Researchen_HK
dc.subject.meshAchilles Tendon - injuriesen_HK
dc.subject.meshAnimalsen_HK
dc.subject.meshDisease Models, Animalen_HK
dc.subject.meshFluorescent Dyes - pharmacologyen_HK
dc.subject.meshLasersen_HK
dc.subject.meshMaleen_HK
dc.subject.meshPhotochemotherapy - methodsen_HK
dc.subject.meshRatsen_HK
dc.subject.meshRats, Sprague-Dawleyen_HK
dc.subject.meshRose Bengal - pharmacologyen_HK
dc.subject.meshRuptureen_HK
dc.subject.meshTendon Injuries - drug therapyen_HK
dc.subject.meshTensile Strengthen_HK
dc.titlePhotochemical repair of Achilles tendon rupture in a rat modelen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0022-4804&volume=124&spage=274&epage=279.&date=2005&atitle=Photochemical+repair+of+Achilles+tendon+rupture+in+a+rat+modelen_HK
dc.identifier.emailChan, BP:bpchan@hkucc.hku.hken_HK
dc.identifier.authorityChan, BP=rp00087en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.jss.2004.09.019en_HK
dc.identifier.pmid15820258-
dc.identifier.scopuseid_2-s2.0-16244376184en_HK
dc.identifier.hkuros137704en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-16244376184&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume124en_HK
dc.identifier.issue2en_HK
dc.identifier.spage274en_HK
dc.identifier.epage279en_HK
dc.identifier.isiWOS:000228275800017-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridChan, BP=7201530390en_HK
dc.identifier.scopusauthoridAmann, C=8278564600en_HK
dc.identifier.scopusauthoridYaroslavsky, AN=6603744337en_HK
dc.identifier.scopusauthoridTitle, C=6506539928en_HK
dc.identifier.scopusauthoridSmink, D=6602627759en_HK
dc.identifier.scopusauthoridZarins, B=7003766048en_HK
dc.identifier.scopusauthoridKochevar, IE=35560618300en_HK
dc.identifier.scopusauthoridRedmond, RW=7005328208en_HK

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