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Article: Selective laser sintering of tissue engineering scaffolds using poly(L-Lactide) microspheres

TitleSelective laser sintering of tissue engineering scaffolds using poly(L-Lactide) microspheres
Authors
KeywordsBone tissue engineering
Poly(L-lactide)
Scaffolds
Selective laser sintering
Issue Date2007
PublisherTrans Tech Publications Ltd. The Journal's web site is located at http://www.scientific.net
Citation
Key Engineering Materials, 2007, v. 334-335 II, p. 1225-1228 How to Cite?
AbstractThis paper reports a study on the modification of a commercial selective laser sintering (SLS) machine for the fabrication of tissue engineering scaffolds from small quantities of poly(L-lactide) (PLLA) microspheres. A miniature build platform was designed, fabricated and installed in the build cylinder of a Sinterstation® 2000 system. Porous scaffolds in the form of rectangular prism, 12.7×12.7×25.4 mm3, with interconnected square and round channels were designed using SolidWorks®. For initial trials, DuraForm™ polyamide powder was used to build scaffolds with a designed porosity of -70%. The actual porosity was found to be ∼83%, which indicated that the sintered regions were not fully dense. PLLA microspheres in the size range of 5-30 μm were made using an oil-in-water emulsion solvent evaporation procedure and they were suitable for the SLS process. A porous scaffold was sintered from the PLLA microspheres with a laser power of 15W and a part bed temperature of 60°C. SEM examination showed that the PLLA microspheres were partially melted to form the scaffold. This study has demonstrated that it is feasible to build tissue engineering scaffolds from small amounts of biomaterials using a commercial SLS machine with suitable modifications.
Persistent Identifierhttp://hdl.handle.net/10722/75562
ISSN
2005 Impact Factor: 0.224
2015 SCImago Journal Rankings: 0.173
References

 

DC FieldValueLanguage
dc.contributor.authorZhou, WYen_HK
dc.contributor.authorLee, SHen_HK
dc.contributor.authorWang, Men_HK
dc.contributor.authorCheung, WLen_HK
dc.date.accessioned2010-09-06T07:12:24Z-
dc.date.available2010-09-06T07:12:24Z-
dc.date.issued2007en_HK
dc.identifier.citationKey Engineering Materials, 2007, v. 334-335 II, p. 1225-1228en_HK
dc.identifier.issn1013-9826en_HK
dc.identifier.urihttp://hdl.handle.net/10722/75562-
dc.description.abstractThis paper reports a study on the modification of a commercial selective laser sintering (SLS) machine for the fabrication of tissue engineering scaffolds from small quantities of poly(L-lactide) (PLLA) microspheres. A miniature build platform was designed, fabricated and installed in the build cylinder of a Sinterstation® 2000 system. Porous scaffolds in the form of rectangular prism, 12.7×12.7×25.4 mm3, with interconnected square and round channels were designed using SolidWorks®. For initial trials, DuraForm™ polyamide powder was used to build scaffolds with a designed porosity of -70%. The actual porosity was found to be ∼83%, which indicated that the sintered regions were not fully dense. PLLA microspheres in the size range of 5-30 μm were made using an oil-in-water emulsion solvent evaporation procedure and they were suitable for the SLS process. A porous scaffold was sintered from the PLLA microspheres with a laser power of 15W and a part bed temperature of 60°C. SEM examination showed that the PLLA microspheres were partially melted to form the scaffold. This study has demonstrated that it is feasible to build tissue engineering scaffolds from small amounts of biomaterials using a commercial SLS machine with suitable modifications.en_HK
dc.languageengen_HK
dc.publisherTrans Tech Publications Ltd. The Journal's web site is located at http://www.scientific.neten_HK
dc.relation.ispartofKey Engineering Materialsen_HK
dc.rightsKey Engineering Materials. Copyright © Trans Tech Publications Ltd.en_HK
dc.subjectBone tissue engineeringen_HK
dc.subjectPoly(L-lactide)en_HK
dc.subjectScaffoldsen_HK
dc.subjectSelective laser sinteringen_HK
dc.titleSelective laser sintering of tissue engineering scaffolds using poly(L-Lactide) microspheresen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1013-9826&volume=334-335&spage=1225&epage=1228&date=2007&atitle=Selective+laser+sintering+of+tissue+engineering+scaffolds+using+Poly(L-lactide)+microspheresen_HK
dc.identifier.emailZhou, WY:wzhou@business.hku.hken_HK
dc.identifier.emailWang, M:memwang@hku.hken_HK
dc.identifier.emailCheung, WL:wlcheung@hkucc.hku.hken_HK
dc.identifier.authorityZhou, WY=rp01128en_HK
dc.identifier.authorityWang, M=rp00185en_HK
dc.identifier.authorityCheung, WL=rp00103en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.scopuseid_2-s2.0-33847032958en_HK
dc.identifier.hkuros132265en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-33847032958&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume334-335 IIen_HK
dc.identifier.spage1225en_HK
dc.identifier.epage1228en_HK
dc.publisher.placeSwitzerlanden_HK
dc.identifier.scopusauthoridZhou, WY=10739745800en_HK
dc.identifier.scopusauthoridLee, SH=7601423055en_HK
dc.identifier.scopusauthoridWang, M=15749714100en_HK
dc.identifier.scopusauthoridCheung, WL=7202743084en_HK

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