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Article: Biological abnormality of impaired reading is constrained by culture

TitleBiological abnormality of impaired reading is constrained by culture
Authors
Issue Date2004
PublisherNature Publishing Group. The Journal's web site is located at http://www.nature.com/nature
Citation
Nature, 2004, v. 430 n. 7004, p. 71-76 How to Cite?
AbstractDevelopmental dyslexia is characterized by a severe reading problem in people who have normal intelligence and schooling. Impaired reading of alphabetic scripts is associated with dysfunction of left temporoparietal brain regions. These regions perform phonemic analysis and conversion of written symbols to phonological units of speech (grapheme-to-phoneme conversion); two central cognitive processes that mediate reading acquisition. Furthermore, it has been assumed that, in contrast to cultural diversities, dyslexia in different languages has a universal biological origin. Here we show using functional magnetic resonance imaging with reading-impaired Chinese children and associated controls, that functional disruption of the left middle frontal gyrus is associated with impaired reading of the Chinese language (a logographic rather than alphabetic writing system). Reading impairment in Chinese is manifested by two deficits: one relating to the conversion of graphic form (orthography) to syllable, and the other concerning orthography-to-semantics mapping. Both of these processes are critically mediated by the left middle frontal gyrus, which functions as a centre for fluent Chinese reading that coordinates and integrates various information about written characters in verbal and spatial working memory. This finding provides an insight into the fundamental pathophysiology of dyslexia by suggesting that rather than having a universal origin, the biological abnormality of impaired reading is dependent on culture.
Persistent Identifierhttp://hdl.handle.net/10722/75065
ISSN
2015 Impact Factor: 38.138
2015 SCImago Journal Rankings: 21.936
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorSiok, WTen_HK
dc.contributor.authorPerfetti, CAen_HK
dc.contributor.authorJin, Zen_HK
dc.contributor.authorTan, LHen_HK
dc.date.accessioned2010-09-06T07:07:30Z-
dc.date.available2010-09-06T07:07:30Z-
dc.date.issued2004en_HK
dc.identifier.citationNature, 2004, v. 430 n. 7004, p. 71-76en_HK
dc.identifier.issn0028-0836en_HK
dc.identifier.urihttp://hdl.handle.net/10722/75065-
dc.description.abstractDevelopmental dyslexia is characterized by a severe reading problem in people who have normal intelligence and schooling. Impaired reading of alphabetic scripts is associated with dysfunction of left temporoparietal brain regions. These regions perform phonemic analysis and conversion of written symbols to phonological units of speech (grapheme-to-phoneme conversion); two central cognitive processes that mediate reading acquisition. Furthermore, it has been assumed that, in contrast to cultural diversities, dyslexia in different languages has a universal biological origin. Here we show using functional magnetic resonance imaging with reading-impaired Chinese children and associated controls, that functional disruption of the left middle frontal gyrus is associated with impaired reading of the Chinese language (a logographic rather than alphabetic writing system). Reading impairment in Chinese is manifested by two deficits: one relating to the conversion of graphic form (orthography) to syllable, and the other concerning orthography-to-semantics mapping. Both of these processes are critically mediated by the left middle frontal gyrus, which functions as a centre for fluent Chinese reading that coordinates and integrates various information about written characters in verbal and spatial working memory. This finding provides an insight into the fundamental pathophysiology of dyslexia by suggesting that rather than having a universal origin, the biological abnormality of impaired reading is dependent on culture.en_HK
dc.languageengen_HK
dc.publisherNature Publishing Group. The Journal's web site is located at http://www.nature.com/natureen_HK
dc.relation.ispartofNatureen_HK
dc.titleBiological abnormality of impaired reading is constrained by cultureen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0028-0836&volume=431&spage=71&epage=76&date=2004&atitle=Biological+abnormality+of+impaired+reading+is+constrained+by+cultureen_HK
dc.identifier.emailSiok, WT: siok@hkucc.hku.hken_HK
dc.identifier.emailTan, LH: tanlh@hku.hken_HK
dc.identifier.authoritySiok, WT=rp01208en_HK
dc.identifier.authorityTan, LH=rp01202en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1038/nature02865en_HK
dc.identifier.pmid15343334-
dc.identifier.scopuseid_2-s2.0-4544271479en_HK
dc.identifier.hkuros92201en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-4544271479&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume430en_HK
dc.identifier.issue7004en_HK
dc.identifier.spage71en_HK
dc.identifier.epage76en_HK
dc.identifier.isiWOS:000223641500043-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridSiok, WT=6602471035en_HK
dc.identifier.scopusauthoridPerfetti, CA=7005318729en_HK
dc.identifier.scopusauthoridJin, Z=46961272300en_HK
dc.identifier.scopusauthoridTan, LH=7402233462en_HK
dc.identifier.citeulike7472311-

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