File Download

There are no files associated with this item.

  Links for fulltext
     (May Require Subscription)
Supplementary

Article: MR diffusion tensor imaging study of postinfarct myocardium structural remodeling in a porcine model

TitleMR diffusion tensor imaging study of postinfarct myocardium structural remodeling in a porcine model
Authors
KeywordsBorderzone
Diffusion tensor imaging
Fiber architecture
Myocardium infarction
Issue Date2007
PublisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www.interscience.wiley.com/jpages/0740-3194/
Citation
Magnetic Resonance In Medicine, 2007, v. 58 n. 4, p. 687-695 How to Cite?
AbstractThis study aimed to investigate postinfarct left ventricular (LV) fiber structural alterations by ex vivo diffusion tensor imaging (DTI) in a porcine heart model. In vivo cardiac MR imaging was first performed to measure ventricular function in six adult pigs with septal infarction near apex induced by the LAD ligation 13 weeks earlier. Hearts were then excised from the infarct pigs (n = 6) and six intact controls (n = 6) and fixed in formalin. High-resolution DTI was employed to examine changes in fractional anisotropy (FA), apparent diffusion coefficient (ADC), and transmural helix angle distribution in the infarct, adjacent and remote regions as compared to the sham regions in the controls. FA values were found to decrease in the infarct and differ between the adjacent and remote regions. ADC increase in the infarct region was substantial, while changes in the adjacent and remote regions were insignificant. Structurally, the double-helix myocardial structure shifted toward more left-handed around the infarcted myocardium. Accordingly, the histological analysis revealed clear fiber structural degradation in the adjacent region. These findings confirmed the subtle alterations in the myocardial fiber quality and structure not only in the infarcted but also in the surrounding noninfarcted myocardium or borderzone. © 2007 Wiley-Liss, Inc.
Persistent Identifierhttp://hdl.handle.net/10722/73989
ISSN
2015 Impact Factor: 3.782
2015 SCImago Journal Rankings: 2.197
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorWu, EXen_HK
dc.contributor.authorWu, Yen_HK
dc.contributor.authorNicholls, JMen_HK
dc.contributor.authorWang, Jen_HK
dc.contributor.authorLiao, Sen_HK
dc.contributor.authorZhu, Sen_HK
dc.contributor.authorLau, CPen_HK
dc.contributor.authorTse, HFen_HK
dc.date.accessioned2010-09-06T06:56:43Z-
dc.date.available2010-09-06T06:56:43Z-
dc.date.issued2007en_HK
dc.identifier.citationMagnetic Resonance In Medicine, 2007, v. 58 n. 4, p. 687-695en_HK
dc.identifier.issn0740-3194en_HK
dc.identifier.urihttp://hdl.handle.net/10722/73989-
dc.description.abstractThis study aimed to investigate postinfarct left ventricular (LV) fiber structural alterations by ex vivo diffusion tensor imaging (DTI) in a porcine heart model. In vivo cardiac MR imaging was first performed to measure ventricular function in six adult pigs with septal infarction near apex induced by the LAD ligation 13 weeks earlier. Hearts were then excised from the infarct pigs (n = 6) and six intact controls (n = 6) and fixed in formalin. High-resolution DTI was employed to examine changes in fractional anisotropy (FA), apparent diffusion coefficient (ADC), and transmural helix angle distribution in the infarct, adjacent and remote regions as compared to the sham regions in the controls. FA values were found to decrease in the infarct and differ between the adjacent and remote regions. ADC increase in the infarct region was substantial, while changes in the adjacent and remote regions were insignificant. Structurally, the double-helix myocardial structure shifted toward more left-handed around the infarcted myocardium. Accordingly, the histological analysis revealed clear fiber structural degradation in the adjacent region. These findings confirmed the subtle alterations in the myocardial fiber quality and structure not only in the infarcted but also in the surrounding noninfarcted myocardium or borderzone. © 2007 Wiley-Liss, Inc.en_HK
dc.languageengen_HK
dc.publisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www.interscience.wiley.com/jpages/0740-3194/en_HK
dc.relation.ispartofMagnetic Resonance in Medicineen_HK
dc.rightsMagnetic Resonance in Medicine. Copyright © John Wiley & Sons, Inc.en_HK
dc.subjectBorderzoneen_HK
dc.subjectDiffusion tensor imagingen_HK
dc.subjectFiber architectureen_HK
dc.subjectMyocardium infarctionen_HK
dc.subject.meshAnimalsen_HK
dc.subject.meshAnisotropyen_HK
dc.subject.meshDiffusion Magnetic Resonance Imagingen_HK
dc.subject.meshDisease Models, Animalen_HK
dc.subject.meshMyocardial Infarction - pathologyen_HK
dc.subject.meshSwineen_HK
dc.subject.meshSwine, Miniatureen_HK
dc.subject.meshVentricular Remodeling - physiologyen_HK
dc.titleMR diffusion tensor imaging study of postinfarct myocardium structural remodeling in a porcine modelen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0740-3194&volume=&spage=687&epage=95&date=2007&atitle=MR+diffusion+tensor+imaging+study+of+postinfarct+myocardium+structural+remodeling+in+a+porcine+modelen_HK
dc.identifier.emailWu, EX:ewu1@hkucc.hku.hken_HK
dc.identifier.emailNicholls, JM:nicholls@pathology.hku.hken_HK
dc.identifier.emailTse, HF:hftse@hkucc.hku.hken_HK
dc.identifier.authorityWu, EX=rp00193en_HK
dc.identifier.authorityNicholls, JM=rp00364en_HK
dc.identifier.authorityTse, HF=rp00428en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1002/mrm.21350en_HK
dc.identifier.pmid17899595-
dc.identifier.scopuseid_2-s2.0-35048876603en_HK
dc.identifier.hkuros142940en_HK
dc.identifier.hkuros141486-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-35048876603&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume58en_HK
dc.identifier.issue4en_HK
dc.identifier.spage687en_HK
dc.identifier.epage695en_HK
dc.identifier.isiWOS:000249849200006-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridWu, EX=7202128034en_HK
dc.identifier.scopusauthoridWu, Y=8940205500en_HK
dc.identifier.scopusauthoridNicholls, JM=7201463077en_HK
dc.identifier.scopusauthoridWang, J=8061150000en_HK
dc.identifier.scopusauthoridLiao, S=22433820700en_HK
dc.identifier.scopusauthoridZhu, S=55237337600en_HK
dc.identifier.scopusauthoridLau, CP=7401968501en_HK
dc.identifier.scopusauthoridTse, HF=7006070805en_HK
dc.identifier.citeulike3874650-

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats