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Article: Rodent EAE model for the study of axon integrity and remyelination

TitleRodent EAE model for the study of axon integrity and remyelination
Authors
KeywordsDemyelinating diseases
CNS
Multiple sclerosis
Spinal cord
Inflammation
Issue Date2007
PublisherNature Publishing Group. The Journal's web site is located at http://www.natureprotocols.com/about.php
Citation
Protocol Exchange, 2007 How to Cite?
AbstractMyelin oligodendrocyte glycoprotein (MOG)-induced murine experimental autoimmune encephalomyelitis (EAE) is a widely accepted model for studying the clinical and pathological features of multiple sclerosis (MS). The model has previously been used to demonstrate that fostering remyelination can be effective in moderating disease progression. Approaches to enhance myelination include the transplantation of OPCs, Schwann cells, olfactory ensheathing cells, or neural stem cells into the primary demyelinated lesions1, or the promotion of oligodendrocyte precursor cell (OPC) differentiation2-5, such as by LINGO-1 antagonism6,7. Functional recovery from demyelination can be assessed via approaches for the histological preparation of tissues for light microscopy, magnetic resonance DTI imaging, and electron microscopy, as presented in this protocol.
Persistent Identifierhttp://hdl.handle.net/10722/73530
ISSN

 

DC FieldValueLanguage
dc.contributor.authorMi, Sen_HK
dc.contributor.authorHu, Ben_HK
dc.contributor.authorHahm, Ken_HK
dc.contributor.authorLuo, Yen_HK
dc.contributor.authorHui, ESKen_HK
dc.contributor.authorYuan, Qen_HK
dc.contributor.authorWong, WMen_HK
dc.contributor.authorWang, Len_HK
dc.contributor.authorSu, Hen_HK
dc.contributor.authorChu, THen_HK
dc.contributor.authorGuo, Jen_HK
dc.contributor.authorZhang, Wen_HK
dc.contributor.authorSo, KFen_HK
dc.contributor.authorPepinsky, Ben_HK
dc.contributor.authorShao, Zen_HK
dc.contributor.authorGraff, Christilynen_HK
dc.contributor.authorGarber, Ellen-
dc.contributor.authorJung, V-
dc.contributor.authorWu, EX-
dc.contributor.authorWu, W-
dc.date.accessioned2010-09-06T06:52:14Z-
dc.date.available2010-09-06T06:52:14Z-
dc.date.issued2007en_HK
dc.identifier.citationProtocol Exchange, 2007en_HK
dc.identifier.issn1750-2799en_HK
dc.identifier.urihttp://hdl.handle.net/10722/73530-
dc.description.abstractMyelin oligodendrocyte glycoprotein (MOG)-induced murine experimental autoimmune encephalomyelitis (EAE) is a widely accepted model for studying the clinical and pathological features of multiple sclerosis (MS). The model has previously been used to demonstrate that fostering remyelination can be effective in moderating disease progression. Approaches to enhance myelination include the transplantation of OPCs, Schwann cells, olfactory ensheathing cells, or neural stem cells into the primary demyelinated lesions1, or the promotion of oligodendrocyte precursor cell (OPC) differentiation2-5, such as by LINGO-1 antagonism6,7. Functional recovery from demyelination can be assessed via approaches for the histological preparation of tissues for light microscopy, magnetic resonance DTI imaging, and electron microscopy, as presented in this protocol.-
dc.languageengen_HK
dc.publisherNature Publishing Group. The Journal's web site is located at http://www.natureprotocols.com/about.phpen_HK
dc.relation.ispartofProtocol Exchangeen_HK
dc.subjectDemyelinating diseases-
dc.subjectCNS-
dc.subjectMultiple sclerosis-
dc.subjectSpinal cord-
dc.subjectInflammation-
dc.titleRodent EAE model for the study of axon integrity and remyelinationen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1750-2799&volume=&spage=389 (DOI:10.1038)&epage=&date=2007&atitle=Rodent+EAE+model+for+study+of+axon+integrity+and+remyelinationen_HK
dc.identifier.emailWu, EX: ewu@eee.hku.hken_HK
dc.identifier.authorityWu, EX=rp00193en_HK
dc.identifier.doi10.1038/nprot.2007.389-
dc.identifier.hkuros141488en_HK
dc.publisher.placeUnited Kingdom-

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