File Download
  • No File Attached
 
Links for fulltext
(May Require Subscription)
 
Supplementary

Article: Toxicity of pharmaceutical wastewater on male reproductive system of Mus musculus
  • Basic View
  • Metadata View
  • XML View
TitleToxicity of pharmaceutical wastewater on male reproductive system of Mus musculus
 
AuthorsZhao, D1
Zhu, C1
Sun, S1
Yu, H3
Zhang, L3
Pan, W1
Zhang, X1
Yu, H1
Gu, J2
Cheng, S1
 
KeywordsFlow cytometry
Histopathology
Pharmaceutical wastewater
Sperm abnormality
Spermatogenic cells
 
Issue Date2007
 
PublisherSage Publications Ltd. The Journal's web site is located at http://tih.sagepub.com
 
CitationToxicology And Industrial Health, 2007, v. 23 n. 1, p. 47-54 [How to Cite?]
DOI: http://dx.doi.org/10.1177/0748233707077446
 
AbstractThis study reports on the toxic effects of 35-days intragastric perfusion of pharmaceutical wastewater on the male reproductive system of Mus musculus. Flow cytometric analyses and staining with fluorescein diacetate (FDA) and propidium iodide (PI) were used to assess the toxicity on spermatogenic cells. Significant depletions in the relative percentages of elongated spermatid (HC), diploid spermatogonia (2C), and S-phase cells were observed. These alterations in different germ cell populations were reflected in the various germ cell ratios. The ratios of 1C : 4C and HC : 2C showed a significant decline after pharmaceutical wastewater treatment, while the 4C : 2C and 1C : 2C ratios increased significantly. FDA and PI staining displayed reduced viability of spermatogenic cells in wastewater treated group. Statistically significant percentages of sperm abnormalities showed the genotoxic potential of this pharmaceutical wastewater. Testicular histopathological studies of treated animals revealed expansion of interstitial space and reduction in the number and size of Leydig cells. Thus, the present study has established the toxicity of pharmaceutical wastewater on the reproductive biology of male mice. © 2007 SAGE Publications.
 
ISSN0748-2337
2013 Impact Factor: 1.710
 
DOIhttp://dx.doi.org/10.1177/0748233707077446
 
ISI Accession Number IDWOS:000247355400006
 
ReferencesReferences in Scopus
 
DC FieldValue
dc.contributor.authorZhao, D
 
dc.contributor.authorZhu, C
 
dc.contributor.authorSun, S
 
dc.contributor.authorYu, H
 
dc.contributor.authorZhang, L
 
dc.contributor.authorPan, W
 
dc.contributor.authorZhang, X
 
dc.contributor.authorYu, H
 
dc.contributor.authorGu, J
 
dc.contributor.authorCheng, S
 
dc.date.accessioned2010-09-06T06:51:39Z
 
dc.date.available2010-09-06T06:51:39Z
 
dc.date.issued2007
 
dc.description.abstractThis study reports on the toxic effects of 35-days intragastric perfusion of pharmaceutical wastewater on the male reproductive system of Mus musculus. Flow cytometric analyses and staining with fluorescein diacetate (FDA) and propidium iodide (PI) were used to assess the toxicity on spermatogenic cells. Significant depletions in the relative percentages of elongated spermatid (HC), diploid spermatogonia (2C), and S-phase cells were observed. These alterations in different germ cell populations were reflected in the various germ cell ratios. The ratios of 1C : 4C and HC : 2C showed a significant decline after pharmaceutical wastewater treatment, while the 4C : 2C and 1C : 2C ratios increased significantly. FDA and PI staining displayed reduced viability of spermatogenic cells in wastewater treated group. Statistically significant percentages of sperm abnormalities showed the genotoxic potential of this pharmaceutical wastewater. Testicular histopathological studies of treated animals revealed expansion of interstitial space and reduction in the number and size of Leydig cells. Thus, the present study has established the toxicity of pharmaceutical wastewater on the reproductive biology of male mice. © 2007 SAGE Publications.
 
dc.description.naturelink_to_subscribed_fulltext
 
dc.identifier.citationToxicology And Industrial Health, 2007, v. 23 n. 1, p. 47-54 [How to Cite?]
DOI: http://dx.doi.org/10.1177/0748233707077446
 
dc.identifier.doihttp://dx.doi.org/10.1177/0748233707077446
 
dc.identifier.epage54
 
dc.identifier.hkuros160862
 
dc.identifier.isiWOS:000247355400006
 
dc.identifier.issn0748-2337
2013 Impact Factor: 1.710
 
dc.identifier.issue1
 
dc.identifier.openurl
 
dc.identifier.pmid17722739
 
dc.identifier.scopuseid_2-s2.0-34250775013
 
dc.identifier.spage47
 
dc.identifier.urihttp://hdl.handle.net/10722/73481
 
dc.identifier.volume23
 
dc.languageeng
 
dc.publisherSage Publications Ltd. The Journal's web site is located at http://tih.sagepub.com
 
dc.publisher.placeUnited Kingdom
 
dc.relation.ispartofToxicology and Industrial Health
 
dc.relation.referencesReferences in Scopus
 
dc.rightsToxicology and Industrial Health. Copyright © Sage Publications Ltd.
 
dc.subjectFlow cytometry
 
dc.subjectHistopathology
 
dc.subjectPharmaceutical wastewater
 
dc.subjectSperm abnormality
 
dc.subjectSpermatogenic cells
 
dc.titleToxicity of pharmaceutical wastewater on male reproductive system of Mus musculus
 
dc.typeArticle
 
<?xml encoding="utf-8" version="1.0"?>
<item><contributor.author>Zhao, D</contributor.author>
<contributor.author>Zhu, C</contributor.author>
<contributor.author>Sun, S</contributor.author>
<contributor.author>Yu, H</contributor.author>
<contributor.author>Zhang, L</contributor.author>
<contributor.author>Pan, W</contributor.author>
<contributor.author>Zhang, X</contributor.author>
<contributor.author>Yu, H</contributor.author>
<contributor.author>Gu, J</contributor.author>
<contributor.author>Cheng, S</contributor.author>
<date.accessioned>2010-09-06T06:51:39Z</date.accessioned>
<date.available>2010-09-06T06:51:39Z</date.available>
<date.issued>2007</date.issued>
<identifier.citation>Toxicology And Industrial Health, 2007, v. 23 n. 1, p. 47-54</identifier.citation>
<identifier.issn>0748-2337</identifier.issn>
<identifier.uri>http://hdl.handle.net/10722/73481</identifier.uri>
<description.abstract>This study reports on the toxic effects of 35-days intragastric perfusion of pharmaceutical wastewater on the male reproductive system of Mus musculus. Flow cytometric analyses and staining with fluorescein diacetate (FDA) and propidium iodide (PI) were used to assess the toxicity on spermatogenic cells. Significant depletions in the relative percentages of elongated spermatid (HC), diploid spermatogonia (2C), and S-phase cells were observed. These alterations in different germ cell populations were reflected in the various germ cell ratios. The ratios of 1C : 4C and HC : 2C showed a significant decline after pharmaceutical wastewater treatment, while the 4C : 2C and 1C : 2C ratios increased significantly. FDA and PI staining displayed reduced viability of spermatogenic cells in wastewater treated group. Statistically significant percentages of sperm abnormalities showed the genotoxic potential of this pharmaceutical wastewater. Testicular histopathological studies of treated animals revealed expansion of interstitial space and reduction in the number and size of Leydig cells. Thus, the present study has established the toxicity of pharmaceutical wastewater on the reproductive biology of male mice. &#169; 2007 SAGE Publications.</description.abstract>
<language>eng</language>
<publisher>Sage Publications Ltd. The Journal&apos;s web site is located at http://tih.sagepub.com</publisher>
<relation.ispartof>Toxicology and Industrial Health</relation.ispartof>
<rights>Toxicology and Industrial Health. Copyright &#169; Sage Publications Ltd.</rights>
<subject>Flow cytometry</subject>
<subject>Histopathology</subject>
<subject>Pharmaceutical wastewater</subject>
<subject>Sperm abnormality</subject>
<subject>Spermatogenic cells</subject>
<title>Toxicity of pharmaceutical wastewater on male reproductive system of Mus musculus</title>
<type>Article</type>
<identifier.openurl>http://library.hku.hk:4550/resserv?sid=HKU:IR&amp;issn=0748-2337&amp;volume=23&amp;spage=47&amp;epage=54&amp;date=2007&amp;atitle=Toxicity+of+pharmaceutical+wastewater+on+male+reproductive+system+of+Mus+musculus</identifier.openurl>
<description.nature>link_to_subscribed_fulltext</description.nature>
<identifier.doi>10.1177/0748233707077446</identifier.doi>
<identifier.pmid>17722739</identifier.pmid>
<identifier.scopus>eid_2-s2.0-34250775013</identifier.scopus>
<identifier.hkuros>160862</identifier.hkuros>
<relation.references>http://www.scopus.com/mlt/select.url?eid=2-s2.0-34250775013&amp;selection=ref&amp;src=s&amp;origin=recordpage</relation.references>
<identifier.volume>23</identifier.volume>
<identifier.issue>1</identifier.issue>
<identifier.spage>47</identifier.spage>
<identifier.epage>54</identifier.epage>
<identifier.isi>WOS:000247355400006</identifier.isi>
<publisher.place>United Kingdom</publisher.place>
</item>
Author Affiliations
  1. Nanjing University
  2. The University of Hong Kong
  3. China University of Mining and Technology Xuzhou