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Article: Toxicity of pharmaceutical wastewater on male reproductive system of Mus musculus

TitleToxicity of pharmaceutical wastewater on male reproductive system of Mus musculus
Authors
KeywordsFlow cytometry
Histopathology
Pharmaceutical wastewater
Sperm abnormality
Spermatogenic cells
Issue Date2007
PublisherSage Publications Ltd. The Journal's web site is located at http://tih.sagepub.com
Citation
Toxicology And Industrial Health, 2007, v. 23 n. 1, p. 47-54 How to Cite?
AbstractThis study reports on the toxic effects of 35-days intragastric perfusion of pharmaceutical wastewater on the male reproductive system of Mus musculus. Flow cytometric analyses and staining with fluorescein diacetate (FDA) and propidium iodide (PI) were used to assess the toxicity on spermatogenic cells. Significant depletions in the relative percentages of elongated spermatid (HC), diploid spermatogonia (2C), and S-phase cells were observed. These alterations in different germ cell populations were reflected in the various germ cell ratios. The ratios of 1C : 4C and HC : 2C showed a significant decline after pharmaceutical wastewater treatment, while the 4C : 2C and 1C : 2C ratios increased significantly. FDA and PI staining displayed reduced viability of spermatogenic cells in wastewater treated group. Statistically significant percentages of sperm abnormalities showed the genotoxic potential of this pharmaceutical wastewater. Testicular histopathological studies of treated animals revealed expansion of interstitial space and reduction in the number and size of Leydig cells. Thus, the present study has established the toxicity of pharmaceutical wastewater on the reproductive biology of male mice. © 2007 SAGE Publications.
Persistent Identifierhttp://hdl.handle.net/10722/73481
ISSN
2014 Impact Factor: 1.859
2014 SCImago Journal Rankings: 0.419
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorZhao, Den_HK
dc.contributor.authorZhu, Cen_HK
dc.contributor.authorSun, Sen_HK
dc.contributor.authorYu, Hen_HK
dc.contributor.authorZhang, Len_HK
dc.contributor.authorPan, Wen_HK
dc.contributor.authorZhang, Xen_HK
dc.contributor.authorYu, Hen_HK
dc.contributor.authorGu, Jen_HK
dc.contributor.authorCheng, Sen_HK
dc.date.accessioned2010-09-06T06:51:39Z-
dc.date.available2010-09-06T06:51:39Z-
dc.date.issued2007en_HK
dc.identifier.citationToxicology And Industrial Health, 2007, v. 23 n. 1, p. 47-54en_HK
dc.identifier.issn0748-2337en_HK
dc.identifier.urihttp://hdl.handle.net/10722/73481-
dc.description.abstractThis study reports on the toxic effects of 35-days intragastric perfusion of pharmaceutical wastewater on the male reproductive system of Mus musculus. Flow cytometric analyses and staining with fluorescein diacetate (FDA) and propidium iodide (PI) were used to assess the toxicity on spermatogenic cells. Significant depletions in the relative percentages of elongated spermatid (HC), diploid spermatogonia (2C), and S-phase cells were observed. These alterations in different germ cell populations were reflected in the various germ cell ratios. The ratios of 1C : 4C and HC : 2C showed a significant decline after pharmaceutical wastewater treatment, while the 4C : 2C and 1C : 2C ratios increased significantly. FDA and PI staining displayed reduced viability of spermatogenic cells in wastewater treated group. Statistically significant percentages of sperm abnormalities showed the genotoxic potential of this pharmaceutical wastewater. Testicular histopathological studies of treated animals revealed expansion of interstitial space and reduction in the number and size of Leydig cells. Thus, the present study has established the toxicity of pharmaceutical wastewater on the reproductive biology of male mice. © 2007 SAGE Publications.en_HK
dc.languageengen_HK
dc.publisherSage Publications Ltd. The Journal's web site is located at http://tih.sagepub.comen_HK
dc.relation.ispartofToxicology and Industrial Healthen_HK
dc.rightsToxicology and Industrial Health. Copyright © Sage Publications Ltd.en_HK
dc.subjectFlow cytometryen_HK
dc.subjectHistopathologyen_HK
dc.subjectPharmaceutical wastewateren_HK
dc.subjectSperm abnormalityen_HK
dc.subjectSpermatogenic cellsen_HK
dc.titleToxicity of pharmaceutical wastewater on male reproductive system of Mus musculusen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0748-2337&volume=23&spage=47&epage=54&date=2007&atitle=Toxicity+of+pharmaceutical+wastewater+on+male+reproductive+system+of+Mus+musculusen_HK
dc.identifier.emailGu, J: jdgu@hkucc.hku.hken_HK
dc.identifier.authorityGu, J=rp00701en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1177/0748233707077446en_HK
dc.identifier.pmid17722739en_HK
dc.identifier.scopuseid_2-s2.0-34250775013en_HK
dc.identifier.hkuros160862en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-34250775013&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume23en_HK
dc.identifier.issue1en_HK
dc.identifier.spage47en_HK
dc.identifier.epage54en_HK
dc.identifier.isiWOS:000247355400006-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridZhao, D=25522963400en_HK
dc.identifier.scopusauthoridZhu, C=23972049400en_HK
dc.identifier.scopusauthoridSun, S=8555122200en_HK
dc.identifier.scopusauthoridYu, H=23500929500en_HK
dc.identifier.scopusauthoridZhang, L=15039912500en_HK
dc.identifier.scopusauthoridPan, W=14049194900en_HK
dc.identifier.scopusauthoridZhang, X=8555121100en_HK
dc.identifier.scopusauthoridYu, H=7405852208en_HK
dc.identifier.scopusauthoridGu, J=7403129601en_HK
dc.identifier.scopusauthoridCheng, S=18039405400en_HK

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