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Article: PTA wastewater molecular toxicity detected with gene chip

TitlePTA wastewater molecular toxicity detected with gene chip
Authors
KeywordsGene chip
Male mice
Molecular toxicity
Predication of security
PTA wastewater
Issue Date2006
PublisherI O S Press. The Journal's web site is located at http://www.iospress.nl/html/10010742.php
Citation
Journal Of Environmental Sciences, 2006, v. 18 n. 3, p. 514-518 How to Cite?
AbstractThe purified terephthalic acid (PTA) petrochemical wastewater molecular toxicity detected by use of Mouse Genome 430A 2.0 GeneChip was conducted in this research. The toxic dose to male mice was 0.03 g/(kg·d) of PTA in the wastewater. The mice liver total RNA was isolated as the temple for synthesis of cDNA and then the cDNA as the temple for synthesis of cRNA. Hybridizing the cRNA with the target genes on the gene chip, there were 232 genes expression levels up-regulated and 74 genes down-regulated discovered obviously. The foremost 40 genes for both the highest and the lowest expression levels involved endogenetic steroid and hormone metabolism, immune system, the leukocyte activity and inflammation, detoxification in liver, reproduction and growth hormone, regulation immune factors of anti-tumor and anti-infection and cancer to the mice sampled. The data suggest the PTA wastewater contained over 5 aromatics and their toxicities integrated were much higher than the pure chemical PTA. And the pure chemical PTA toxicities data cannot be used to evaluate the toxicity of the PTA wastewater instead. © 2006 Science Press. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/73471
ISSN
2015 Impact Factor: 2.208
2015 SCImago Journal Rankings: 0.832
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorZhu, CJen_HK
dc.contributor.authorCheng, SPen_HK
dc.contributor.authorZhang, XXen_HK
dc.contributor.authorLang, YZen_HK
dc.contributor.authorSun, SLen_HK
dc.contributor.authorGu, JDen_HK
dc.contributor.authorZhao, DYen_HK
dc.contributor.authorPan, WYen_HK
dc.contributor.authorYu, HXen_HK
dc.date.accessioned2010-09-06T06:51:34Z-
dc.date.available2010-09-06T06:51:34Z-
dc.date.issued2006en_HK
dc.identifier.citationJournal Of Environmental Sciences, 2006, v. 18 n. 3, p. 514-518en_HK
dc.identifier.issn1001-0742en_HK
dc.identifier.urihttp://hdl.handle.net/10722/73471-
dc.description.abstractThe purified terephthalic acid (PTA) petrochemical wastewater molecular toxicity detected by use of Mouse Genome 430A 2.0 GeneChip was conducted in this research. The toxic dose to male mice was 0.03 g/(kg·d) of PTA in the wastewater. The mice liver total RNA was isolated as the temple for synthesis of cDNA and then the cDNA as the temple for synthesis of cRNA. Hybridizing the cRNA with the target genes on the gene chip, there were 232 genes expression levels up-regulated and 74 genes down-regulated discovered obviously. The foremost 40 genes for both the highest and the lowest expression levels involved endogenetic steroid and hormone metabolism, immune system, the leukocyte activity and inflammation, detoxification in liver, reproduction and growth hormone, regulation immune factors of anti-tumor and anti-infection and cancer to the mice sampled. The data suggest the PTA wastewater contained over 5 aromatics and their toxicities integrated were much higher than the pure chemical PTA. And the pure chemical PTA toxicities data cannot be used to evaluate the toxicity of the PTA wastewater instead. © 2006 Science Press. All rights reserved.en_HK
dc.languageengen_HK
dc.publisherI O S Press. The Journal's web site is located at http://www.iospress.nl/html/10010742.phpen_HK
dc.relation.ispartofJournal of Environmental Sciencesen_HK
dc.rightsJournal of Environmental Sciences. Copyright © I O S Press.en_HK
dc.subjectGene chipen_HK
dc.subjectMale miceen_HK
dc.subjectMolecular toxicityen_HK
dc.subjectPredication of securityen_HK
dc.subjectPTA wastewateren_HK
dc.titlePTA wastewater molecular toxicity detected with gene chipen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1001-0742&volume=18&spage=514&epage=518&date=2006&atitle=PTA+wastewater+molecular+toxicity+detected+with+gene+chipen_HK
dc.identifier.emailGu, JD: jdgu@hkucc.hku.hken_HK
dc.identifier.authorityGu, JD=rp00701en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.pmid17294649-
dc.identifier.scopuseid_2-s2.0-33746344326en_HK
dc.identifier.hkuros134275en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-33746344326&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume18en_HK
dc.identifier.issue3en_HK
dc.identifier.spage514en_HK
dc.identifier.epage518en_HK
dc.identifier.isiWOS:000237568200017-
dc.publisher.placeNetherlandsen_HK
dc.identifier.scopusauthoridZhu, CJ=23972049400en_HK
dc.identifier.scopusauthoridCheng, SP=18039405400en_HK
dc.identifier.scopusauthoridZhang, XX=35316674200en_HK
dc.identifier.scopusauthoridLang, YZ=49763301300en_HK
dc.identifier.scopusauthoridSun, SL=8555122200en_HK
dc.identifier.scopusauthoridGu, JD=7403129601en_HK
dc.identifier.scopusauthoridZhao, DY=25522963400en_HK
dc.identifier.scopusauthoridPan, WY=14049194900en_HK
dc.identifier.scopusauthoridYu, HX=7405852208en_HK

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