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Article: Myocardial T2 quantitation in patients with iron overload at 3 Tesla

TitleMyocardial T2 quantitation in patients with iron overload at 3 Tesla
Authors
KeywordsCardiac MR
Heart
Iron overload
Liver
MRI
T2
T2*
Thalassemia
Tissue iron
Issue Date2009
PublisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www.interscience.wiley.com/jpages/1053-1807/
Citation
Journal Of Magnetic Resonance Imaging, 2009, v. 30 n. 2, p. 394-400 How to Cite?
AbstractPurpose: To investigate the feasibility of measuring myocardial T2 at 3 Tesla for assessment of tissue iron in thalassemia major and other iron overloaded patients. Materials and Methods: A single-breathhold electrocardiogram-triggered black-blood multi-echo spin-echo (MESE) sequence with a turbo factor of 2 was implemented at 3 Tesla (T). Myocardial and liver T2 values were measured with three repeated breathholds in 8 normal subjects and 24 patients. Their values, together with the T2* values measured using a breathhold multi-echo gradient-echo sequence, were compared with those at 1.5T in the same patients. Results: At 3T, myocardial T2 was found to be 39.6 ± 7.4 ms in normal subjects. In patients, it ranged from 12.9 to 50.1 ms. T2 and T2* were observed to correlate in heart (ρ = 0.93, ρ = 0.0001) and liver (P = 0.95, P < 0.0001). Myocardial T2 and T2* at 3T were also highly correlated with the 1.5T measurements. Preliminary results indicated that myocardial T2 quantitation was relatively insensitive to B1 variation, and reproducible with 3.2% intra-exam and 3.8% inter-exam variations. Conclusion: Myocardial T2 quantitation is feasible at 3T. Given the substantially decreased T2* and increased B0 inhomogeneity, the rapid myocardial T2 measurement protocol demonstrated here may present a robust alternative to study cardiac iron overload at 3T. © 2009 Wiley-Liss, Inc.
Persistent Identifierhttp://hdl.handle.net/10722/72407
ISSN
2015 Impact Factor: 3.25
2015 SCImago Journal Rankings: 1.683
ISI Accession Number ID
Funding AgencyGrant Number
Hong Kong Research Grant CouncilCRF7794/07M
Hong Kong Children Thalassaemia Foundation2007/02
National Institutes of HealthR01-DK069373
R01-DK066251
R37-DK049108
R01-DK049108
American Heart Association0730143N
Funding Information:

Contract grant sponsor: Hong Kong Research Grant Council; Contract grant number: CRF7794/07M; Contract grant sponsor: Hong Kong Children Thalassaemia Foundation: Contract grant number: 2007/02; Contract grant sponsor: National Institutes of Health; Contract grant number: R01-DK069373; Contract grant number: R01-DK066251; Contract grant number: R37-DK049108: Contract grant number: R01-DK049108: Contract grant sponsor: American Heart Association; Contract grant number: 0730143N.

References

 

DC FieldValueLanguage
dc.contributor.authorGuo, Hen_HK
dc.contributor.authorAu, WYen_HK
dc.contributor.authorCheung, JSen_HK
dc.contributor.authorKim, Den_HK
dc.contributor.authorJensen, JHen_HK
dc.contributor.authorKhong, PLen_HK
dc.contributor.authorChan, Qen_HK
dc.contributor.authorChan, KCen_HK
dc.contributor.authorTosti, Cen_HK
dc.contributor.authorTang, Hen_HK
dc.contributor.authorBrown, TRen_HK
dc.contributor.authorLam, WWMen_HK
dc.contributor.authorHa, SYen_HK
dc.contributor.authorBrittenham, GMen_HK
dc.contributor.authorWu, EXen_HK
dc.date.accessioned2010-09-06T06:41:25Z-
dc.date.available2010-09-06T06:41:25Z-
dc.date.issued2009en_HK
dc.identifier.citationJournal Of Magnetic Resonance Imaging, 2009, v. 30 n. 2, p. 394-400en_HK
dc.identifier.issn1053-1807en_HK
dc.identifier.urihttp://hdl.handle.net/10722/72407-
dc.description.abstractPurpose: To investigate the feasibility of measuring myocardial T2 at 3 Tesla for assessment of tissue iron in thalassemia major and other iron overloaded patients. Materials and Methods: A single-breathhold electrocardiogram-triggered black-blood multi-echo spin-echo (MESE) sequence with a turbo factor of 2 was implemented at 3 Tesla (T). Myocardial and liver T2 values were measured with three repeated breathholds in 8 normal subjects and 24 patients. Their values, together with the T2* values measured using a breathhold multi-echo gradient-echo sequence, were compared with those at 1.5T in the same patients. Results: At 3T, myocardial T2 was found to be 39.6 ± 7.4 ms in normal subjects. In patients, it ranged from 12.9 to 50.1 ms. T2 and T2* were observed to correlate in heart (ρ = 0.93, ρ = 0.0001) and liver (P = 0.95, P < 0.0001). Myocardial T2 and T2* at 3T were also highly correlated with the 1.5T measurements. Preliminary results indicated that myocardial T2 quantitation was relatively insensitive to B1 variation, and reproducible with 3.2% intra-exam and 3.8% inter-exam variations. Conclusion: Myocardial T2 quantitation is feasible at 3T. Given the substantially decreased T2* and increased B0 inhomogeneity, the rapid myocardial T2 measurement protocol demonstrated here may present a robust alternative to study cardiac iron overload at 3T. © 2009 Wiley-Liss, Inc.en_HK
dc.languageengen_HK
dc.publisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www.interscience.wiley.com/jpages/1053-1807/en_HK
dc.relation.ispartofJournal of Magnetic Resonance Imagingen_HK
dc.rightsJournal of Magnetic Resonance Imaging . Copyright © John Wiley & Sons, Inc.en_HK
dc.subjectCardiac MRen_HK
dc.subjectHearten_HK
dc.subjectIron overloaden_HK
dc.subjectLiveren_HK
dc.subjectMRIen_HK
dc.subjectT2en_HK
dc.subjectT2*en_HK
dc.subjectThalassemiaen_HK
dc.subjectTissue ironen_HK
dc.subject.meshAdolescenten_HK
dc.subject.meshAdulten_HK
dc.subject.meshAgeden_HK
dc.subject.meshElectrocardiographyen_HK
dc.subject.meshFeasibility Studiesen_HK
dc.subject.meshFemaleen_HK
dc.subject.meshHumansen_HK
dc.subject.meshImage Enhancement - methodsen_HK
dc.subject.meshIron Overload - pathologyen_HK
dc.subject.meshMagnetic Resonance Imaging - methodsen_HK
dc.subject.meshMaleen_HK
dc.subject.meshMiddle Ageden_HK
dc.subject.meshMyocardium - pathologyen_HK
dc.subject.meshReference Valuesen_HK
dc.subject.meshReproducibility of Resultsen_HK
dc.subject.meshThalassemia - pathologyen_HK
dc.titleMyocardial T2 quantitation in patients with iron overload at 3 Teslaen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1053-1807&volume=30&spage=394&epage=400&date=2009&atitle=Myocardial+T2+quantitation+in+patients+with+iron+overload+at+3+teslaen_HK
dc.identifier.emailKhong, PL:plkhong@hkucc.hku.hken_HK
dc.identifier.emailWu, EX:ewu1@hkucc.hku.hken_HK
dc.identifier.authorityKhong, PL=rp00467en_HK
dc.identifier.authorityWu, EX=rp00193en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1002/jmri.21851en_HK
dc.identifier.pmid19629983en_HK
dc.identifier.scopuseid_2-s2.0-68049142606en_HK
dc.identifier.hkuros161075en_HK
dc.identifier.hkuros177124-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-68049142606&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume30en_HK
dc.identifier.issue2en_HK
dc.identifier.spage394en_HK
dc.identifier.epage400en_HK
dc.identifier.isiWOS:000268609900020-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridGuo, H=12774450700en_HK
dc.identifier.scopusauthoridAu, WY=7202383089en_HK
dc.identifier.scopusauthoridCheung, JS=16174280400en_HK
dc.identifier.scopusauthoridKim, D=8524290700en_HK
dc.identifier.scopusauthoridJensen, JH=7404521984en_HK
dc.identifier.scopusauthoridKhong, PL=7006693233en_HK
dc.identifier.scopusauthoridChan, Q=6602497305en_HK
dc.identifier.scopusauthoridChan, KC=34968940300en_HK
dc.identifier.scopusauthoridTosti, C=10641524200en_HK
dc.identifier.scopusauthoridTang, H=36827331000en_HK
dc.identifier.scopusauthoridBrown, TR=7404319370en_HK
dc.identifier.scopusauthoridLam, WWM=13410486800en_HK
dc.identifier.scopusauthoridHa, SY=7202501115en_HK
dc.identifier.scopusauthoridBrittenham, GM=7005583587en_HK
dc.identifier.scopusauthoridWu, EX=7202128034en_HK

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