Article: White matter volume and anisotropy in preterm children: A pilot study of neurocognitive correlates

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TitleWhite matter volume and anisotropy in preterm children: A pilot study of neurocognitive correlates
AuthorsYung, A1
Poon, G1
Qiu, DQ1
Chu, J2
Lam, B1
Leung, C1
Goh, W1
Khong, PL1
Issue Date2007
PublisherLippincott Williams & Wilkins. The Journal's web site is located at http://www.pedresearch.org/
CitationPediatric Research, 2007, v. 61 n. 6, p. 732-736 [How to Cite?]
DOI: http://dx.doi.org/10.1203/pdr.0b013e31805365db
AbstractThe objectives of this study were to evaluate the differences in whole brain white matter (WM) volume and anisotropy between preterm and term children and to determine the relationships with cognitive outcome. Twenty-five low birth weight (BW), preterm, neurologically normal children between 8.8 and 11.5 y of age were recruited for volumetric and diffusion-tensor magnetic resonance imaging (DTI), together with 13 age-matched term control subjects. Subsequent intelligence quotient (IQ) testing was performed for 21 preterm children within 6 mo of imaging studies. We computed the mean volume and fractional anisotropy (FA) of the whole brain WM and compared the differences between the two groups. Mean WM volume and FA were significantly lower in the preterm group (p = 0.014 and p < 0.001, respectively). Multiple regression analysis found both WM volume and FA to be independent variables significantly affecting full scale IQ (FSIQ) (r = 0.407, p = 0.021 and r = 0.496, p = 0.005, respectively) after adjusting for BW, gestational age (GA), and gender. In the evaluation of the whole brain WM of preterm children, we found that both volume and FA remain reduced at late childhood with both parameters significantly affecting long-term cognitive outcome. © International Pediatrics Research Foundation, Inc. 2007. All Rights Reserved.
ISSN0031-3998
2011 Impact Factor: 2.7
2011 SCImago Journal Rankings: 0.238
DOIhttp://dx.doi.org/10.1203/pdr.0b013e31805365db
ISI Accession Number IDWOS:000246787300020
ReferencesReferences in Scopus
DC Field
Value
dc.contributor.authorYung, A
dc.contributor.authorPoon, G
dc.contributor.authorQiu, DQ
dc.contributor.authorChu, J
dc.contributor.authorLam, B
dc.contributor.authorLeung, C
dc.contributor.authorGoh, W
dc.contributor.authorKhong, PL
dc.date.accessioned2010-09-06T06:41:21Z
dc.date.available2010-09-06T06:41:21Z
dc.date.issued2007
dc.description.abstractThe objectives of this study were to evaluate the differences in whole brain white matter (WM) volume and anisotropy between preterm and term children and to determine the relationships with cognitive outcome. Twenty-five low birth weight (BW), preterm, neurologically normal children between 8.8 and 11.5 y of age were recruited for volumetric and diffusion-tensor magnetic resonance imaging (DTI), together with 13 age-matched term control subjects. Subsequent intelligence quotient (IQ) testing was performed for 21 preterm children within 6 mo of imaging studies. We computed the mean volume and fractional anisotropy (FA) of the whole brain WM and compared the differences between the two groups. Mean WM volume and FA were significantly lower in the preterm group (p = 0.014 and p < 0.001, respectively). Multiple regression analysis found both WM volume and FA to be independent variables significantly affecting full scale IQ (FSIQ) (r = 0.407, p = 0.021 and r = 0.496, p = 0.005, respectively) after adjusting for BW, gestational age (GA), and gender. In the evaluation of the whole brain WM of preterm children, we found that both volume and FA remain reduced at late childhood with both parameters significantly affecting long-term cognitive outcome. © International Pediatrics Research Foundation, Inc. 2007. All Rights Reserved.
dc.description.natureLink_to_subscribed_fulltext
dc.identifier.citationPediatric Research, 2007, v. 61 n. 6, p. 732-736 [How to Cite?]
DOI: http://dx.doi.org/10.1203/pdr.0b013e31805365db
dc.identifier.doihttp://dx.doi.org/10.1203/pdr.0b013e31805365db
dc.identifier.epage736
dc.identifier.hkuros128334
dc.identifier.isiWOS:000246787300020
dc.identifier.issn0031-3998
2011 Impact Factor: 2.7
2011 SCImago Journal Rankings: 0.238
dc.identifier.issue6
dc.identifier.openurl
dc.identifier.pmid17426647
dc.identifier.scopuseid_2-s2.0-34249058942
dc.identifier.spage732
dc.identifier.urihttp://hdl.handle.net/10722/72401
dc.identifier.volume61
dc.languageeng
dc.publisherLippincott Williams & Wilkins. The Journal's web site is located at http://www.pedresearch.org/
dc.publisher.placeUnited States
dc.relation.ispartofPediatric Research
dc.relation.referencesReferences in Scopus
dc.rightsPediatric Research. Copyright © Lippincott Williams & Wilkins.
dc.subject.meshBirth Weight
dc.subject.meshBrain - anatomy & histology
dc.subject.meshChild
dc.subject.meshCognition
dc.subject.meshDiffusion Magnetic Resonance Imaging
dc.subject.meshFemale
dc.subject.meshHumans
dc.subject.meshInfant, Newborn
dc.subject.meshInfant, Premature - physiology
dc.subject.meshInfant, Very Low Birth Weight - physiology
dc.subject.meshMale
dc.subject.meshPilot Projects
dc.titleWhite matter volume and anisotropy in preterm children: A pilot study of neurocognitive correlates
dc.typeArticle
Author Affiliations
  1. The University of Hong Kong
  2. Center Child Development