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Article: Severe Acute Respiratory Syndrome: Radiographic Evaluation and Clinical Outcome Measures

TitleSevere Acute Respiratory Syndrome: Radiographic Evaluation and Clinical Outcome Measures
Authors
KeywordsLung, infection
Oxygen
Severe acute respiratory syndrome (SARS)
Issue Date2003
PublisherRadiological Society of North America, Inc. The Journal's web site is located at http://radiology.rsnajnls.org
Citation
Radiology, 2003, v. 229 n. 2, p. 500-506 How to Cite?
AbstractPURPOSE: To evaluate the relationship among chest radiographs, oxygen supplementation requirement, and treatment response in severe acute respiratory syndrome (SARS). MATERIALS AND METHODS: Forty patients (20 women, 20 men; mean age, 42.90 years ± 14.01 [SD]; median age, 41.5 years; age range, 25-82 years) with SARS were evaluated. Daily chest radiographs were graded according to percentage of lung involvement during 20.15 days ± 5.56 (median, 20 days; range, 14-38 days). Times between symptoms and treatment and time to reach maximal radiographic score from admission and treatment day were determined. Daily oxygen saturation (Sao2) and oxygen supplementation including mechanically assisted ventilation were recorded. Treatment response was defined as good, fair, and poor. Patterns of radiographic opacity at admission and at maximal radiographic score were noted. Differences in radiographic and clinical parameters with respect to oxygen supplementation and treatment response were respectively evaluated with Mann-Whitney and Kruskal-Wallis tests. RESULTS: Larger maximal radiographic scores, lower Sao2 at maximal radiographic change, longer time from treatment to maximal radiographic score (P < .01), and diffuse consolidation at maximal radiographic score were associated with oxygen supplementation. Parameters that influenced treatment response were time from symptom onset to treatment day (P = .003), time from admission to treatment day (P < .001), time to maximal radiographic score from treatment day (P = .001), maximal radiographic score (P = .009), Sao2 at maximal radiographic score (P = .13), and treatment radiographic score (P = .03). Fair responders had shorter time between admission and treatment than did either good (P < .001) or poor responders (P = .002) and shorter time between symptoms and treatment (P < .001) and lower treatment radiographic score (P = .012) than did good responders. Good (82%), poor (36%), and fair (33%) responders developed maximal chest radiographic scores within 4 days of treatment (P = .008). Radiographic patterns at both admission and maximal radiographic score did not influence treatment response. CONCLUSION: There are significant relationships among radiographic parameters, oxygen supplementation, and treatment response, and these relationships appear to be clinically useful in the treatment of SARS. © RSNA, 2003.
Persistent Identifierhttp://hdl.handle.net/10722/72399
ISSN
2014 Impact Factor: 6.867
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorOoi, CGCen_HK
dc.contributor.authorKhong, PLen_HK
dc.contributor.authorHo, JCMen_HK
dc.contributor.authorLam, Ben_HK
dc.contributor.authorWong, WMen_HK
dc.contributor.authorYiu, WCen_HK
dc.contributor.authorWong, PCen_HK
dc.contributor.authorWong, CFen_HK
dc.contributor.authorLai, KNen_HK
dc.contributor.authorTsang, KWTen_HK
dc.date.accessioned2010-09-06T06:41:20Z-
dc.date.available2010-09-06T06:41:20Z-
dc.date.issued2003en_HK
dc.identifier.citationRadiology, 2003, v. 229 n. 2, p. 500-506en_HK
dc.identifier.issn0033-8419en_HK
dc.identifier.urihttp://hdl.handle.net/10722/72399-
dc.description.abstractPURPOSE: To evaluate the relationship among chest radiographs, oxygen supplementation requirement, and treatment response in severe acute respiratory syndrome (SARS). MATERIALS AND METHODS: Forty patients (20 women, 20 men; mean age, 42.90 years ± 14.01 [SD]; median age, 41.5 years; age range, 25-82 years) with SARS were evaluated. Daily chest radiographs were graded according to percentage of lung involvement during 20.15 days ± 5.56 (median, 20 days; range, 14-38 days). Times between symptoms and treatment and time to reach maximal radiographic score from admission and treatment day were determined. Daily oxygen saturation (Sao2) and oxygen supplementation including mechanically assisted ventilation were recorded. Treatment response was defined as good, fair, and poor. Patterns of radiographic opacity at admission and at maximal radiographic score were noted. Differences in radiographic and clinical parameters with respect to oxygen supplementation and treatment response were respectively evaluated with Mann-Whitney and Kruskal-Wallis tests. RESULTS: Larger maximal radiographic scores, lower Sao2 at maximal radiographic change, longer time from treatment to maximal radiographic score (P < .01), and diffuse consolidation at maximal radiographic score were associated with oxygen supplementation. Parameters that influenced treatment response were time from symptom onset to treatment day (P = .003), time from admission to treatment day (P < .001), time to maximal radiographic score from treatment day (P = .001), maximal radiographic score (P = .009), Sao2 at maximal radiographic score (P = .13), and treatment radiographic score (P = .03). Fair responders had shorter time between admission and treatment than did either good (P < .001) or poor responders (P = .002) and shorter time between symptoms and treatment (P < .001) and lower treatment radiographic score (P = .012) than did good responders. Good (82%), poor (36%), and fair (33%) responders developed maximal chest radiographic scores within 4 days of treatment (P = .008). Radiographic patterns at both admission and maximal radiographic score did not influence treatment response. CONCLUSION: There are significant relationships among radiographic parameters, oxygen supplementation, and treatment response, and these relationships appear to be clinically useful in the treatment of SARS. © RSNA, 2003.en_HK
dc.languageengen_HK
dc.publisherRadiological Society of North America, Inc. The Journal's web site is located at http://radiology.rsnajnls.orgen_HK
dc.relation.ispartofRadiologyen_HK
dc.subjectLung, infectionen_HK
dc.subjectOxygenen_HK
dc.subjectSevere acute respiratory syndrome (SARS)en_HK
dc.subject.meshAdulten_HK
dc.subject.meshAgeden_HK
dc.subject.meshAged, 80 and overen_HK
dc.subject.meshFemaleen_HK
dc.subject.meshHumansen_HK
dc.subject.meshLung - radiographyen_HK
dc.subject.meshMaleen_HK
dc.subject.meshMiddle Ageden_HK
dc.subject.meshOxygen - blooden_HK
dc.subject.meshOxygen Inhalation Therapyen_HK
dc.subject.meshRespiration, Artificialen_HK
dc.subject.meshSevere Acute Respiratory Syndrome - physiopathology - radiography - therapyen_HK
dc.subject.meshTreatment Outcomeen_HK
dc.titleSevere Acute Respiratory Syndrome: Radiographic Evaluation and Clinical Outcome Measuresen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0033-8419&volume=229&spage=500&epage=506&date=2003&atitle=Severe+acute+respiratory+syndrome:+radiographic+evaluation+and+clinical+outcome+measuresen_HK
dc.identifier.emailKhong, PL: plkhong@hkucc.hku.hken_HK
dc.identifier.emailHo, JCM: jhocm@hku.hken_HK
dc.identifier.emailLai, KN: knlai@hku.hken_HK
dc.identifier.authorityKhong, PL=rp00467en_HK
dc.identifier.authorityHo, JCM=rp00258en_HK
dc.identifier.authorityLai, KN=rp00324en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1148/radiol.2292030737en_HK
dc.identifier.pmid14595150en_HK
dc.identifier.scopuseid_2-s2.0-0142241112en_HK
dc.identifier.hkuros87428en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0142241112&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume229en_HK
dc.identifier.issue2en_HK
dc.identifier.spage500en_HK
dc.identifier.epage506en_HK
dc.identifier.isiWOS:000186169700030-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridOoi, CGC=7007084909en_HK
dc.identifier.scopusauthoridKhong, PL=7006693233en_HK
dc.identifier.scopusauthoridHo, JCM=7402649981en_HK
dc.identifier.scopusauthoridLam, B=9246012800en_HK
dc.identifier.scopusauthoridWong, WM=7403972413en_HK
dc.identifier.scopusauthoridYiu, WC=6602810849en_HK
dc.identifier.scopusauthoridWong, PC=7403979916en_HK
dc.identifier.scopusauthoridWong, CF=36862877300en_HK
dc.identifier.scopusauthoridLai, KN=7402135706en_HK
dc.identifier.scopusauthoridTsang, KWT=7201555024en_HK

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