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Article: White matter fractional anisotrophy differences and correlates of diagnostic symptoms in autism
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TitleWhite matter fractional anisotrophy differences and correlates of diagnostic symptoms in autism
 
AuthorsCheung, C2
Chua, SE2 1
Cheung, V2
Khong, PL2 1
Tai, KS3
Wong, TKW2
Ho, TP2
McAlonan, GM2 1
 
KeywordsBrain
Children
Diffusion tensor
Magnetic resonance imaging
Morphometry
 
Issue Date2009
 
PublisherBlackwell Publishing Ltd. The Journal's web site is located at http://www.blackwellpublishing.com/journals/JCPP
 
CitationJournal Of Child Psychology And Psychiatry And Allied Disciplines, 2009, v. 50 n. 9, p. 1102-1112 [How to Cite?]
DOI: http://dx.doi.org/10.1111/j.1469-7610.2009.02086.x
 
AbstractBackground: Individuals with autism have impairments in 3 domains: communication, social interaction and repetitive behaviours. Our previous work suggested early structural and connectivity abnormalities in prefrontal-striato-temporal-cerebellar networks but it is not clear how these are linked to diagnostic indices. Method: Children with autism (IQ > 70) aged 6 to 14 years old and matched typically developing controls were studied using diffusion tensor imaging. Voxel-based methods were used to compare fractional anisotrophy (FA) measures in each group and to correlate FA measures in the autism group with the diagnostic phenotype described by the Autism Diagnostic Interview - Revised (ADI-R) algorithm for ICD-10. Results: After controlling for the effects of age and white matter volume, we found that FA in the autism group was significantly lower than controls in bilateral prefrontal and temporal regions, especially in the right ventral temporal lobe adjacent to the fusiform gyrus. FA was greater in autism in the right inferior frontal gyrus and left occipital lobe. We observed a tight correlation between lower FA and higher ADI-R diagnostic algorithm scores across white matter tracts extending from these focal regions of group difference. Communication and social reciprocity impairments correlated with lower FA throughout fronto-striato-temporal pathways. Repetitive behaviours correlated with white matter indices in more posterior brain pathways, including splenium of the corpus callosum and cerebellum. Conclusions: Our data support the position that diagnostic symptoms of autism are associated with a core disruption of white matter development. © 2009 Association for Child and Adolescent Mental Health.
 
ISSN0021-9630
2012 Impact Factor: 5.422
2012 SCImago Journal Rankings: 2.449
 
DOIhttp://dx.doi.org/10.1111/j.1469-7610.2009.02086.x
 
ISI Accession Number IDWOS:000269264800008
Funding AgencyGrant Number
University of Hong Kong
Funding Information:

This study was supported by a University of Hong Kong Grant to SEC.

 
ReferencesReferences in Scopus
 
DC FieldValue
dc.contributor.authorCheung, C
 
dc.contributor.authorChua, SE
 
dc.contributor.authorCheung, V
 
dc.contributor.authorKhong, PL
 
dc.contributor.authorTai, KS
 
dc.contributor.authorWong, TKW
 
dc.contributor.authorHo, TP
 
dc.contributor.authorMcAlonan, GM
 
dc.date.accessioned2010-09-06T06:41:19Z
 
dc.date.available2010-09-06T06:41:19Z
 
dc.date.issued2009
 
dc.description.abstractBackground: Individuals with autism have impairments in 3 domains: communication, social interaction and repetitive behaviours. Our previous work suggested early structural and connectivity abnormalities in prefrontal-striato-temporal-cerebellar networks but it is not clear how these are linked to diagnostic indices. Method: Children with autism (IQ > 70) aged 6 to 14 years old and matched typically developing controls were studied using diffusion tensor imaging. Voxel-based methods were used to compare fractional anisotrophy (FA) measures in each group and to correlate FA measures in the autism group with the diagnostic phenotype described by the Autism Diagnostic Interview - Revised (ADI-R) algorithm for ICD-10. Results: After controlling for the effects of age and white matter volume, we found that FA in the autism group was significantly lower than controls in bilateral prefrontal and temporal regions, especially in the right ventral temporal lobe adjacent to the fusiform gyrus. FA was greater in autism in the right inferior frontal gyrus and left occipital lobe. We observed a tight correlation between lower FA and higher ADI-R diagnostic algorithm scores across white matter tracts extending from these focal regions of group difference. Communication and social reciprocity impairments correlated with lower FA throughout fronto-striato-temporal pathways. Repetitive behaviours correlated with white matter indices in more posterior brain pathways, including splenium of the corpus callosum and cerebellum. Conclusions: Our data support the position that diagnostic symptoms of autism are associated with a core disruption of white matter development. © 2009 Association for Child and Adolescent Mental Health.
 
dc.description.naturelink_to_subscribed_fulltext
 
dc.identifier.citationJournal Of Child Psychology And Psychiatry And Allied Disciplines, 2009, v. 50 n. 9, p. 1102-1112 [How to Cite?]
DOI: http://dx.doi.org/10.1111/j.1469-7610.2009.02086.x
 
dc.identifier.citeulike5657758
 
dc.identifier.doihttp://dx.doi.org/10.1111/j.1469-7610.2009.02086.x
 
dc.identifier.eissn1469-7610
 
dc.identifier.epage1112
 
dc.identifier.hkuros162124
 
dc.identifier.isiWOS:000269264800008
Funding AgencyGrant Number
University of Hong Kong
Funding Information:

This study was supported by a University of Hong Kong Grant to SEC.

 
dc.identifier.issn0021-9630
2012 Impact Factor: 5.422
2012 SCImago Journal Rankings: 2.449
 
dc.identifier.issue9
 
dc.identifier.pmid19490309
 
dc.identifier.scopuseid_2-s2.0-69249122419
 
dc.identifier.spage1102
 
dc.identifier.urihttp://hdl.handle.net/10722/72398
 
dc.identifier.volume50
 
dc.languageeng
 
dc.publisherBlackwell Publishing Ltd. The Journal's web site is located at http://www.blackwellpublishing.com/journals/JCPP
 
dc.publisher.placeUnited Kingdom
 
dc.relation.ispartofJournal of Child Psychology and Psychiatry and Allied Disciplines
 
dc.relation.referencesReferences in Scopus
 
dc.rightsThe definitive version is available at www3.interscience.wiley.com
 
dc.subject.meshAutistic Disorder - pathology
 
dc.subject.meshBasal Ganglia - pathology
 
dc.subject.meshBrain - pathology
 
dc.subject.meshCorpus Callosum - pathology
 
dc.subject.meshDiffusion Magnetic Resonance Imaging
 
dc.subjectBrain
 
dc.subjectChildren
 
dc.subjectDiffusion tensor
 
dc.subjectMagnetic resonance imaging
 
dc.subjectMorphometry
 
dc.titleWhite matter fractional anisotrophy differences and correlates of diagnostic symptoms in autism
 
dc.typeArticle
 
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<contributor.author>Tai, KS</contributor.author>
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<contributor.author>Ho, TP</contributor.author>
<contributor.author>McAlonan, GM</contributor.author>
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Author Affiliations
  1. State Key Laboratory for Brain and Cognitive Sciences
  2. The University of Hong Kong
  3. Hospital Authority