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Article: Diffusion tensor imaging of normal white matter maturation from late childhood to young adulthood: Voxel-wise evaluation of mean diffusivity, fractional anisotropy, radial and axial diffusivities, and correlation with reading development

TitleDiffusion tensor imaging of normal white matter maturation from late childhood to young adulthood: Voxel-wise evaluation of mean diffusivity, fractional anisotropy, radial and axial diffusivities, and correlation with reading development
Authors
Issue Date2008
PublisherAcademic Press. The Journal's web site is located at http://www.elsevier.com/locate/ynimg
Citation
Neuroimage, 2008, v. 41 n. 2, p. 223-232 How to Cite?
AbstractUsing diffusion tensor MR imaging (DTI) and advanced voxel-wise analysis tools, we study diffusivity and anisotropy changes of white matter from late childhood to young adulthood, and correlate quantitative diffusion indices with Chinese and English reading performance scores. Seventy-five normal healthy school going ethnic Chinese students and young adults of three age groups were recruited (group 1, n = 24, mean ± SD = 7.4 ± 0.3 years; group 2, n = 27, mean ± SD = 10.3 ± 0.5 years; group 3, n = 24, mean ± SD = 22.8 ± 2.3 years). DTI was performed with 3 mm isotropic resolution to cover the entire brain. Voxel-wise analysis was performed using Tract-Based Spatial Statistics (TBSS) to localize regions of white matter showing significant changes of fractional anisotropy (FA), mean diffusivity (MD), and axial and radial diffusivities between groups. We found increased FA and decreased MD with increasing age in regions of cerebellar white matter, right temporal white matter, and a large portion of the superior frontal and parietal white matter driven by both the reduction of radial diffusivity and axial diffusivity with the former to a greater extent. Changes were continual from late childhood to young adulthood. Findings were confirmed by region-of-interest analysis in specific white matter tracts. After controlling for the effect of age, significant correlation was found between diffusion indices of the anterior limb of the left internal capsule and Chinese reading score (p = 0.05), and of the corona radiata and English reading score (p = 0.026 and p = 0.029 for left and right, respectively).These DTI indices likely reflect the multiple biological processes that occur during brain development which provide the neural substrate for ongoing functional connectivity including for reading development. © 2008 Elsevier Inc. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/72377
ISSN
2015 Impact Factor: 5.463
2015 SCImago Journal Rankings: 4.464
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorQiu, Den_HK
dc.contributor.authorTan, LHen_HK
dc.contributor.authorZhou, Ken_HK
dc.contributor.authorKhong, PLen_HK
dc.date.accessioned2010-09-06T06:41:06Z-
dc.date.available2010-09-06T06:41:06Z-
dc.date.issued2008en_HK
dc.identifier.citationNeuroimage, 2008, v. 41 n. 2, p. 223-232en_HK
dc.identifier.issn1053-8119en_HK
dc.identifier.urihttp://hdl.handle.net/10722/72377-
dc.description.abstractUsing diffusion tensor MR imaging (DTI) and advanced voxel-wise analysis tools, we study diffusivity and anisotropy changes of white matter from late childhood to young adulthood, and correlate quantitative diffusion indices with Chinese and English reading performance scores. Seventy-five normal healthy school going ethnic Chinese students and young adults of three age groups were recruited (group 1, n = 24, mean ± SD = 7.4 ± 0.3 years; group 2, n = 27, mean ± SD = 10.3 ± 0.5 years; group 3, n = 24, mean ± SD = 22.8 ± 2.3 years). DTI was performed with 3 mm isotropic resolution to cover the entire brain. Voxel-wise analysis was performed using Tract-Based Spatial Statistics (TBSS) to localize regions of white matter showing significant changes of fractional anisotropy (FA), mean diffusivity (MD), and axial and radial diffusivities between groups. We found increased FA and decreased MD with increasing age in regions of cerebellar white matter, right temporal white matter, and a large portion of the superior frontal and parietal white matter driven by both the reduction of radial diffusivity and axial diffusivity with the former to a greater extent. Changes were continual from late childhood to young adulthood. Findings were confirmed by region-of-interest analysis in specific white matter tracts. After controlling for the effect of age, significant correlation was found between diffusion indices of the anterior limb of the left internal capsule and Chinese reading score (p = 0.05), and of the corona radiata and English reading score (p = 0.026 and p = 0.029 for left and right, respectively).These DTI indices likely reflect the multiple biological processes that occur during brain development which provide the neural substrate for ongoing functional connectivity including for reading development. © 2008 Elsevier Inc. All rights reserved.en_HK
dc.languageengen_HK
dc.publisherAcademic Press. The Journal's web site is located at http://www.elsevier.com/locate/ynimgen_HK
dc.relation.ispartofNeuroImageen_HK
dc.subject.meshAdolescenten_HK
dc.subject.meshAdulten_HK
dc.subject.meshAnisotropyen_HK
dc.subject.meshBrain - growth & development - physiologyen_HK
dc.subject.meshChilden_HK
dc.subject.meshDiffusion Magnetic Resonance Imagingen_HK
dc.subject.meshFemaleen_HK
dc.subject.meshHumansen_HK
dc.subject.meshImage Processing, Computer-Assisteden_HK
dc.subject.meshMaleen_HK
dc.subject.meshReadingen_HK
dc.titleDiffusion tensor imaging of normal white matter maturation from late childhood to young adulthood: Voxel-wise evaluation of mean diffusivity, fractional anisotropy, radial and axial diffusivities, and correlation with reading developmenten_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1053-8119&volume=14&spage=223&epage=232&date=2008&atitle=Diffusion+Tensor+Imaging+of+normal+white+matter+maturation+from+late+childhood+to+young+adulthood:+voxel-wise+evaluation+of+mean+diffusivity,+fractional+anisotropy,+radial+and+axial+diffusivities,+and+correlation+with+reading+developmenten_HK
dc.identifier.emailTan, LH: tanlh@hku.hken_HK
dc.identifier.emailKhong, PL: plkhong@hkucc.hku.hken_HK
dc.identifier.authorityTan, LH=rp01202en_HK
dc.identifier.authorityKhong, PL=rp00467en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.neuroimage.2008.02.023en_HK
dc.identifier.pmid18395471-
dc.identifier.scopuseid_2-s2.0-44149104573en_HK
dc.identifier.hkuros143268en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-44149104573&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume41en_HK
dc.identifier.issue2en_HK
dc.identifier.spage223en_HK
dc.identifier.epage232en_HK
dc.identifier.eissn1095-9572-
dc.identifier.isiWOS:000256271100005-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridQiu, D=12778150600en_HK
dc.identifier.scopusauthoridTan, LH=7402233462en_HK
dc.identifier.scopusauthoridZhou, K=36246938500en_HK
dc.identifier.scopusauthoridKhong, PL=7006693233en_HK

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