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Article: Hypoxic-ischemic brain injury in the neonatal rat model: Relationship between lesion size at early MR imaging and irreversible infarction

TitleHypoxic-ischemic brain injury in the neonatal rat model: Relationship between lesion size at early MR imaging and irreversible infarction
Authors
Issue Date2006
PublisherAmerican Society of Neuroradiology. The Journal's web site is located at http://www.ajnr.org
Citation
American Journal Of Neuroradiology, 2006, v. 27 n. 1, p. 51-54 How to Cite?
AbstractBACKGROUND AND PURPOSE: By using a neonatal rat hypoxia-ischemia (HI) model, we studied the relationship between lesion volume - measured by diffusion-weighted imaging (DWI) and T2-weighted imaging (T2WI) at an early time point - and irreversible infarct volume. We also evaluated the optimal apparent diffusion coefficient (ADC) threshold that provides the best correlation with irreversible infarct size. MATERIALS AND METHODS: Twenty-three neonatal rats underwent right common carotid artery ligation and hypoxia. MR imaging was performed 1-2 hours post-HI by using DWI and T2WI and at day 4 post-HI by using T2WI. Lesion volumes relative to whole brain (%LV) were measured on ADC maps by using different relative ADC thresholds 60%-80% of mean contralateral ADC and T2WI. Pearson correlation and multiple linear regression analysis were used to study the relationships between ln(%LV) at MR imaging and %LV at histopathology. RESULTS: At 1-2 hours post-HI, all lesion volume measurements on DWI were significantly correlated with the infarct volume on histopathology, with the best correlation attained at the 80% ADC threshold (r = 0.738; P < .001). The estimated regression formula was %LV on histopathology = 20.60 + 3.33 In(%LV on 80% ADC threshold) (adjusted R 2 = 0.523; P < .001). Lesion volume at 1-2 hours post-HI tended to underestimate the final infarct volume. CONCLUSION: Early post-HI MR imaging by using DWI correlates moderately well with the size of irreversible infarct, especially when measured by using a relative ADC threshold of 80% mean contralateral ADC.
Persistent Identifierhttp://hdl.handle.net/10722/72375
ISSN
2015 Impact Factor: 3.124
2015 SCImago Journal Rankings: 1.602
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorWang, Yen_HK
dc.contributor.authorCheung, PTen_HK
dc.contributor.authorShen, GXen_HK
dc.contributor.authorWu, EXen_HK
dc.contributor.authorCao, Gen_HK
dc.contributor.authorBart, Ien_HK
dc.contributor.authorWong, WHSen_HK
dc.contributor.authorKhong, PLen_HK
dc.date.accessioned2010-09-06T06:41:05Z-
dc.date.available2010-09-06T06:41:05Z-
dc.date.issued2006en_HK
dc.identifier.citationAmerican Journal Of Neuroradiology, 2006, v. 27 n. 1, p. 51-54en_HK
dc.identifier.issn0195-6108en_HK
dc.identifier.urihttp://hdl.handle.net/10722/72375-
dc.description.abstractBACKGROUND AND PURPOSE: By using a neonatal rat hypoxia-ischemia (HI) model, we studied the relationship between lesion volume - measured by diffusion-weighted imaging (DWI) and T2-weighted imaging (T2WI) at an early time point - and irreversible infarct volume. We also evaluated the optimal apparent diffusion coefficient (ADC) threshold that provides the best correlation with irreversible infarct size. MATERIALS AND METHODS: Twenty-three neonatal rats underwent right common carotid artery ligation and hypoxia. MR imaging was performed 1-2 hours post-HI by using DWI and T2WI and at day 4 post-HI by using T2WI. Lesion volumes relative to whole brain (%LV) were measured on ADC maps by using different relative ADC thresholds 60%-80% of mean contralateral ADC and T2WI. Pearson correlation and multiple linear regression analysis were used to study the relationships between ln(%LV) at MR imaging and %LV at histopathology. RESULTS: At 1-2 hours post-HI, all lesion volume measurements on DWI were significantly correlated with the infarct volume on histopathology, with the best correlation attained at the 80% ADC threshold (r = 0.738; P < .001). The estimated regression formula was %LV on histopathology = 20.60 + 3.33 In(%LV on 80% ADC threshold) (adjusted R 2 = 0.523; P < .001). Lesion volume at 1-2 hours post-HI tended to underestimate the final infarct volume. CONCLUSION: Early post-HI MR imaging by using DWI correlates moderately well with the size of irreversible infarct, especially when measured by using a relative ADC threshold of 80% mean contralateral ADC.en_HK
dc.languageengen_HK
dc.publisherAmerican Society of Neuroradiology. The Journal's web site is located at http://www.ajnr.orgen_HK
dc.relation.ispartofAmerican Journal of Neuroradiologyen_HK
dc.titleHypoxic-ischemic brain injury in the neonatal rat model: Relationship between lesion size at early MR imaging and irreversible infarctionen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0195-6108&volume=27&spage=51&epage=54&date=2006&atitle=Hypoxic-ischemic+brain+injury+in+the+neonatal+rat+model:+relationship+between+lesion+size+at+early+MR+imaging+and+irreversible+infarctionen_HK
dc.identifier.emailCheung, PT: ptcheung@hku.hken_HK
dc.identifier.emailShen, GX: gxshen@eee.hku.hken_HK
dc.identifier.emailWu, EX: ewu1@hkucc.hku.hken_HK
dc.identifier.emailKhong, PL: plkhong@hkucc.hku.hken_HK
dc.identifier.authorityCheung, PT=rp00351en_HK
dc.identifier.authorityShen, GX=rp00166en_HK
dc.identifier.authorityWu, EX=rp00193en_HK
dc.identifier.authorityKhong, PL=rp00467en_HK
dc.description.naturelink_to_OA_fulltext-
dc.identifier.pmid16418355-
dc.identifier.scopuseid_2-s2.0-33644868837en_HK
dc.identifier.hkuros114478en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-33644868837&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume27en_HK
dc.identifier.issue1en_HK
dc.identifier.spage51en_HK
dc.identifier.epage54en_HK
dc.identifier.isiWOS:000234779600021-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridWang, Y=7601514650en_HK
dc.identifier.scopusauthoridCheung, PT=7202595465en_HK
dc.identifier.scopusauthoridShen, GX=7401967224en_HK
dc.identifier.scopusauthoridWu, EX=7202128034en_HK
dc.identifier.scopusauthoridCao, G=12776387400en_HK
dc.identifier.scopusauthoridBart, I=12774466300en_HK
dc.identifier.scopusauthoridWong, WHS=13310222200en_HK
dc.identifier.scopusauthoridKhong, PL=7006693233en_HK

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