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Article: Comparing diffusion-weighted and T2-weighted MR imaging for the quantification of infarct size in a neonatal rat hypoxic-ischemic model at 24 h post-injury

TitleComparing diffusion-weighted and T2-weighted MR imaging for the quantification of infarct size in a neonatal rat hypoxic-ischemic model at 24 h post-injury
Authors
KeywordsApparent diffusion coefficient
Diffusion-weighted
Hypoxic-ischemic
Neonatal rat
T2-weighted
Issue Date2007
PublisherPergamon. The Journal's web site is located at http://www.elsevier.com/locate/ijdevneu
Citation
International Journal Of Developmental Neuroscience, 2007, v. 25 n. 1, p. 1-5 How to Cite?
AbstractPurpose: In a neonatal rat model of hypoxic-ischemic (HI) brain injury, using T2-weighted imaging (T2WI) and diffusion-weighted imaging (DWI), we aim to determine the best MRI method of lesion quantification that reflects infarct size. Materials and methods: Twenty 7-day-old rats underwent MRI 24 h after HI brain injury was induced. Lesion size relative to whole brain was measured using T2WI and apparent diffusion coefficient (ADC) maps, applying thresholds of 60%, 70% and 80% contralateral control hemisphere mean ADC, and at day 10 post-HI on pathology with TTC staining. Multiple linear regression analysis was used to study the relationships between lesion size at MRI and pathology. Results: Lesion size measurement using all MRI methods significantly correlated with infarct size at pathology; using T2WI, r = 0.808 (p < 0.001), using 80% ADC, 70% ADC and 60% ADC thresholds, r = 0.888 (p < 0.001), 0.761, (p < 0.001) and 0.569 (p = 0.014), respectively. Eighty percent ADC threshold was found to be the only significant independent predictor of final infarct volume (adjusted R 2 = 0.775). Conclusion: At 24 h post-HI, lesion size on DWI, using 80% ADC threshold is the best predictor of final infarct volume. Although T2WI performed less well, it has the advantage of superior spatial resolution and is technically less demanding. These are important considerations for experiments which utilize MRI as a surrogate method for lesion quantification in the neonatal rat HI model. © 2006 ISDN.
Persistent Identifierhttp://hdl.handle.net/10722/72361
ISSN
2015 Impact Factor: 2.38
2015 SCImago Journal Rankings: 1.109
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorWang, Yen_HK
dc.contributor.authorCheung, PTen_HK
dc.contributor.authorShen, GXen_HK
dc.contributor.authorBhatia, Ien_HK
dc.contributor.authorWu, EXen_HK
dc.contributor.authorQiu, Den_HK
dc.contributor.authorKhong, PLen_HK
dc.date.accessioned2010-09-06T06:40:56Z-
dc.date.available2010-09-06T06:40:56Z-
dc.date.issued2007en_HK
dc.identifier.citationInternational Journal Of Developmental Neuroscience, 2007, v. 25 n. 1, p. 1-5en_HK
dc.identifier.issn0736-5748en_HK
dc.identifier.urihttp://hdl.handle.net/10722/72361-
dc.description.abstractPurpose: In a neonatal rat model of hypoxic-ischemic (HI) brain injury, using T2-weighted imaging (T2WI) and diffusion-weighted imaging (DWI), we aim to determine the best MRI method of lesion quantification that reflects infarct size. Materials and methods: Twenty 7-day-old rats underwent MRI 24 h after HI brain injury was induced. Lesion size relative to whole brain was measured using T2WI and apparent diffusion coefficient (ADC) maps, applying thresholds of 60%, 70% and 80% contralateral control hemisphere mean ADC, and at day 10 post-HI on pathology with TTC staining. Multiple linear regression analysis was used to study the relationships between lesion size at MRI and pathology. Results: Lesion size measurement using all MRI methods significantly correlated with infarct size at pathology; using T2WI, r = 0.808 (p < 0.001), using 80% ADC, 70% ADC and 60% ADC thresholds, r = 0.888 (p < 0.001), 0.761, (p < 0.001) and 0.569 (p = 0.014), respectively. Eighty percent ADC threshold was found to be the only significant independent predictor of final infarct volume (adjusted R 2 = 0.775). Conclusion: At 24 h post-HI, lesion size on DWI, using 80% ADC threshold is the best predictor of final infarct volume. Although T2WI performed less well, it has the advantage of superior spatial resolution and is technically less demanding. These are important considerations for experiments which utilize MRI as a surrogate method for lesion quantification in the neonatal rat HI model. © 2006 ISDN.en_HK
dc.languageengen_HK
dc.publisherPergamon. The Journal's web site is located at http://www.elsevier.com/locate/ijdevneuen_HK
dc.relation.ispartofInternational Journal of Developmental Neuroscienceen_HK
dc.subjectApparent diffusion coefficienten_HK
dc.subjectDiffusion-weighteden_HK
dc.subjectHypoxic-ischemicen_HK
dc.subjectNeonatal raten_HK
dc.subjectT2-weighteden_HK
dc.subject.meshAnimalsen_HK
dc.subject.meshAnimals, Newbornen_HK
dc.subject.meshBrain Infarction - etiology - pathologyen_HK
dc.subject.meshDisease Models, Animalen_HK
dc.subject.meshHypoxia-Ischemia, Brain - complicationsen_HK
dc.subject.meshImage Processing, Computer-Assisteden_HK
dc.subject.meshMagnetic Resonance Imaging - methodsen_HK
dc.subject.meshRatsen_HK
dc.subject.meshRats, Sprague-Dawleyen_HK
dc.titleComparing diffusion-weighted and T2-weighted MR imaging for the quantification of infarct size in a neonatal rat hypoxic-ischemic model at 24 h post-injuryen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0736-5748&volume=25&spage=1&epage=5&date=2007&atitle=Comparing+diffusion-weighted+and+T2-weighted+MR+imaging+for+the+quantification+of+infarct+size+in+a+neonatal+rat+hypoxic-ischemic+model+at+24+h+post-injuryen_HK
dc.identifier.emailCheung, PT: ptcheung@hku.hken_HK
dc.identifier.emailShen, GX: gxshen@eee.hku.hken_HK
dc.identifier.emailWu, EX: ewu1@hkucc.hku.hken_HK
dc.identifier.emailKhong, PL: plkhong@hkucc.hku.hken_HK
dc.identifier.authorityCheung, PT=rp00351en_HK
dc.identifier.authorityShen, GX=rp00166en_HK
dc.identifier.authorityWu, EX=rp00193en_HK
dc.identifier.authorityKhong, PL=rp00467en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.ijdevneu.2006.12.003en_HK
dc.identifier.pmid17229540-
dc.identifier.scopuseid_2-s2.0-33846474269en_HK
dc.identifier.hkuros127711en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-33846474269&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume25en_HK
dc.identifier.issue1en_HK
dc.identifier.spage1en_HK
dc.identifier.epage5en_HK
dc.identifier.isiWOS:000244368900001-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridWang, Y=7601514650en_HK
dc.identifier.scopusauthoridCheung, PT=7202595465en_HK
dc.identifier.scopusauthoridShen, GX=7401967224en_HK
dc.identifier.scopusauthoridBhatia, I=24597420400en_HK
dc.identifier.scopusauthoridWu, EX=7202128034en_HK
dc.identifier.scopusauthoridQiu, D=12778150600en_HK
dc.identifier.scopusauthoridKhong, PL=7006693233en_HK

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