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Article: Exceptionally low metabolic activity in aggressive peripheral T-cell lymphoma

TitleExceptionally low metabolic activity in aggressive peripheral T-cell lymphoma
Authors
Issue Date2009
PublisherLippincott Williams & Wilkins. The Journal's web site is located at http://www.nuclearmedicinecomm.com
Citation
Nuclear Medicine Communications, 2009, v. 30 n. 11, p. 838-840 How to Cite?
AbstractPURPOSE: To investigate metabolic behavior of aggressive peripheral T-cell (PTC) lymphoma compared with other aggressive T-cell (OTC) nonHodgkin's lymphomas (NHLs) and the various grades (1, 2, 3) of follicular B-cell (FC) NHL as a reference cell type for indolent to aggressive behavior. MATERIALS AND METHODS: Pretreatment 2-deoxy-2-[(1)F] fluoro-d-glucose positron emission tomography-computed tomography scans of 33 patients with pathologic diagnosis of aggressive T-cell NHL and FC (FC1 = 6, FC2 = 8, FC3 = 9, PTC = 6, OTC = 4) were analyzed. The maximal standardized uptake value (SUV) was measured over biopsy region (BxSUV) and the highest tumor activity of the body (BmSUV). RESULTS: There were significant differences in both BxSUV (P = 0.036) and BmSUV (P = 0.026) among these five groups with significantly lower metabolic activity in PTC compared with other aggressive NHL (FC3, OTC). BmSUV in PTC was significantly lower than that in OTC (8.2 +/- 2.5 vs. 22.3 +/- 7.0, P = 0.029) and was similar to that of FC1 (9.4 +/- 1.9) and FC2 (9.7 +/- 1.4) but lower than that of FC3 (14.6 +/- 2.7). Similar findings were noted in BxSUV between PTC and OTC (6.7 +/- 2.5 vs. 20.4 +/- 7.2, P = 0.035). CONCLUSION: Although 2-deoxy-2-[(1)F]fluoro-d-glucose positron emission tomography has been found to reflect metabolic activity for the aggressiveness of B-cell NHL, PTC has an exceptionally low metabolic activity, similar to that of low-grade B-cell FC1 and FC2.
Persistent Identifierhttp://hdl.handle.net/10722/72356
ISSN
2015 Impact Factor: 1.453
2015 SCImago Journal Rankings: 0.690
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorTang, Ben_HK
dc.contributor.authorDouglas-Nikitin, Ven_HK
dc.contributor.authorBalon, Hen_HK
dc.contributor.authorWong, COen_HK
dc.contributor.authorKhong, PLen_HK
dc.contributor.authorWong, CYOen_HK
dc.date.accessioned2010-09-06T06:40:52Z-
dc.date.available2010-09-06T06:40:52Z-
dc.date.issued2009en_HK
dc.identifier.citationNuclear Medicine Communications, 2009, v. 30 n. 11, p. 838-840en_HK
dc.identifier.issn0143-3636en_HK
dc.identifier.urihttp://hdl.handle.net/10722/72356-
dc.description.abstractPURPOSE: To investigate metabolic behavior of aggressive peripheral T-cell (PTC) lymphoma compared with other aggressive T-cell (OTC) nonHodgkin's lymphomas (NHLs) and the various grades (1, 2, 3) of follicular B-cell (FC) NHL as a reference cell type for indolent to aggressive behavior. MATERIALS AND METHODS: Pretreatment 2-deoxy-2-[(1)F] fluoro-d-glucose positron emission tomography-computed tomography scans of 33 patients with pathologic diagnosis of aggressive T-cell NHL and FC (FC1 = 6, FC2 = 8, FC3 = 9, PTC = 6, OTC = 4) were analyzed. The maximal standardized uptake value (SUV) was measured over biopsy region (BxSUV) and the highest tumor activity of the body (BmSUV). RESULTS: There were significant differences in both BxSUV (P = 0.036) and BmSUV (P = 0.026) among these five groups with significantly lower metabolic activity in PTC compared with other aggressive NHL (FC3, OTC). BmSUV in PTC was significantly lower than that in OTC (8.2 +/- 2.5 vs. 22.3 +/- 7.0, P = 0.029) and was similar to that of FC1 (9.4 +/- 1.9) and FC2 (9.7 +/- 1.4) but lower than that of FC3 (14.6 +/- 2.7). Similar findings were noted in BxSUV between PTC and OTC (6.7 +/- 2.5 vs. 20.4 +/- 7.2, P = 0.035). CONCLUSION: Although 2-deoxy-2-[(1)F]fluoro-d-glucose positron emission tomography has been found to reflect metabolic activity for the aggressiveness of B-cell NHL, PTC has an exceptionally low metabolic activity, similar to that of low-grade B-cell FC1 and FC2.-
dc.languageengen_HK
dc.publisherLippincott Williams & Wilkins. The Journal's web site is located at http://www.nuclearmedicinecomm.comen_HK
dc.relation.ispartofNuclear Medicine Communicationsen_HK
dc.subject.meshFluorodeoxyglucose F18 - diagnostic use - metabolism-
dc.subject.meshHumans-
dc.subject.meshLymphoma, T-Cell, Peripheral - metabolism - pathology - radiography - radionuclide imaging-
dc.subject.meshPositron-Emission Tomography-
dc.subject.meshTomography, X-Ray Computed-
dc.titleExceptionally low metabolic activity in aggressive peripheral T-cell lymphomaen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0143-3636&volume=30&issue=11&spage=838&epage=840&date=2009&atitle=Exceptionally+low+metabolic+activity+in+aggressive+peripheral+T-cell+lymphomaen_HK
dc.identifier.emailKhong, PL: plkhong@hkucc.hku.hken_HK
dc.identifier.authorityKhong, PL=rp00467en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1097/MNM.0b013e32832e87fc-
dc.identifier.pmid19734816-
dc.identifier.scopuseid_2-s2.0-73249125616-
dc.identifier.hkuros169780en_HK
dc.identifier.volume30-
dc.identifier.issue11-
dc.identifier.spage838-
dc.identifier.epage840-
dc.identifier.isiWOS:000270700800003-

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