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Article: Role of circulating endothelial progenitor cells in patients with rheumatoid arthritis with coronary calcification

TitleRole of circulating endothelial progenitor cells in patients with rheumatoid arthritis with coronary calcification
Authors
KeywordsArterial calcification
Endothelial progenitor Cells
Rheumatoid arthritis
Issue Date2010
PublisherJournal of Rheumatology Publishing Co Ltd. The Journal's web site is located at http://www.jrheum.com
Citation
Journal Of Rheumatology, 2010, v. 37 n. 3, p. 529-535 How to Cite?
AbstractObjective. Patients with rheumatoid arthritis (RA) are prone to premature atherosclerosis. We hypothesize that depletion of circulating endothelial progenitor cells (EPC) related to RA can contribute to the development of atherosclerosis. Methods. We studied coronary calcifications by multidetector computed tomography and their relationship with different subtypes of circulating EPC in 70 patients with RA and 35 age- and sex-matched controls (mean age 54.1 ± 10.2 yrs, 87% were women). The presence of coronary atherosclerosis was defined as an Agatston score ≥ 10. Four subpopulations of EPC were determined by flow cytometry on the basis of surface expression of CD34, CD133, and KDR antigen: CD34+, CD34/KDR+, CD133+, and CD133/KDR+ EPC, respectively. Results. Among those with RA, 15 patients (21%) had coronary atherosclerosis. The mean Agatston score was higher (61.8 ± 201.7 vs 0.14 ± 0.69; p = 0.01) and coronary atherosclerosis was more prevalent (21.4% vs 0%; p < 0.01) in patients with RA compared to controls. RA patients with coronary atherosclerosis were older (66.2 ± 6.9 vs 51.5 ± 16.2 yrs; p < 0.01), had higher prevalence of hypertension (46.7% vs 14.5%; p = 0.01), and had lower CD133/KDR+ (0.45% ± 0.28% vs 0.89% ± 0.81%; p < 0.01) and CD133+ EPC levels (0.74% ± 0.39% vs 1.22% ± 0.83%; p < 0.01), but similar CD34/KDR+ and CD34+ EPC levels (all p > 0.05) compared to those without. Multiple logistic regression revealed that older age (OR 1.25, 95% CI 1.10-1.41, p < 0.01) and lower CD133/KDR+ EPC (OR 0.07, 95% CI 0.00-0.97, p < 0.01) were independent predictors for coronary atherosclerosis in patients with RA. Conclusion. Our results demonstrated that RA patients with coronary atherosclerosis have significantly lower levels of CD133/KDR+ and CD133+ EPC than those without. In addition to older age, lower levels of circulating CD133/KDR+ EPC also predicted occurrence of coronary atherosclerosis in RA patients. The Journal of Rheumatology Copyright © 2010. All rights reserved.
DescriptionComment in J Rheumatol. 2010 Mar;37(3):479-481.
Persistent Identifierhttp://hdl.handle.net/10722/72343
ISSN
2015 Impact Factor: 3.236
2015 SCImago Journal Rankings: 1.225
ISI Accession Number ID
Funding AgencyGrant Number
San Chieh Yeh Heart Foundation
Funding Information:

Supported by the San Chieh Yeh Heart Foundation.

References

 

DC FieldValueLanguage
dc.contributor.authorYiu, KHen_HK
dc.contributor.authorWang, Sen_HK
dc.contributor.authorMok, MYen_HK
dc.contributor.authorOoi, GCen_HK
dc.contributor.authorKhong, PLen_HK
dc.contributor.authorLau, CPen_HK
dc.contributor.authorLai, WHen_HK
dc.contributor.authorWong, LYen_HK
dc.contributor.authorLam, KFen_HK
dc.contributor.authorLau, CSen_HK
dc.contributor.authorTse, HFen_HK
dc.date.accessioned2010-09-06T06:40:44Z-
dc.date.available2010-09-06T06:40:44Z-
dc.date.issued2010en_HK
dc.identifier.citationJournal Of Rheumatology, 2010, v. 37 n. 3, p. 529-535en_HK
dc.identifier.issn0315-162Xen_HK
dc.identifier.urihttp://hdl.handle.net/10722/72343-
dc.descriptionComment in J Rheumatol. 2010 Mar;37(3):479-481.-
dc.description.abstractObjective. Patients with rheumatoid arthritis (RA) are prone to premature atherosclerosis. We hypothesize that depletion of circulating endothelial progenitor cells (EPC) related to RA can contribute to the development of atherosclerosis. Methods. We studied coronary calcifications by multidetector computed tomography and their relationship with different subtypes of circulating EPC in 70 patients with RA and 35 age- and sex-matched controls (mean age 54.1 ± 10.2 yrs, 87% were women). The presence of coronary atherosclerosis was defined as an Agatston score ≥ 10. Four subpopulations of EPC were determined by flow cytometry on the basis of surface expression of CD34, CD133, and KDR antigen: CD34+, CD34/KDR+, CD133+, and CD133/KDR+ EPC, respectively. Results. Among those with RA, 15 patients (21%) had coronary atherosclerosis. The mean Agatston score was higher (61.8 ± 201.7 vs 0.14 ± 0.69; p = 0.01) and coronary atherosclerosis was more prevalent (21.4% vs 0%; p < 0.01) in patients with RA compared to controls. RA patients with coronary atherosclerosis were older (66.2 ± 6.9 vs 51.5 ± 16.2 yrs; p < 0.01), had higher prevalence of hypertension (46.7% vs 14.5%; p = 0.01), and had lower CD133/KDR+ (0.45% ± 0.28% vs 0.89% ± 0.81%; p < 0.01) and CD133+ EPC levels (0.74% ± 0.39% vs 1.22% ± 0.83%; p < 0.01), but similar CD34/KDR+ and CD34+ EPC levels (all p > 0.05) compared to those without. Multiple logistic regression revealed that older age (OR 1.25, 95% CI 1.10-1.41, p < 0.01) and lower CD133/KDR+ EPC (OR 0.07, 95% CI 0.00-0.97, p < 0.01) were independent predictors for coronary atherosclerosis in patients with RA. Conclusion. Our results demonstrated that RA patients with coronary atherosclerosis have significantly lower levels of CD133/KDR+ and CD133+ EPC than those without. In addition to older age, lower levels of circulating CD133/KDR+ EPC also predicted occurrence of coronary atherosclerosis in RA patients. The Journal of Rheumatology Copyright © 2010. All rights reserved.en_HK
dc.languageengen_HK
dc.publisherJournal of Rheumatology Publishing Co Ltd. The Journal's web site is located at http://www.jrheum.comen_HK
dc.relation.ispartofJournal of Rheumatologyen_HK
dc.subjectArterial calcificationen_HK
dc.subjectEndothelial progenitor Cellsen_HK
dc.subjectRheumatoid arthritisen_HK
dc.subject.meshAging - immunology - metabolism-
dc.subject.meshArthritis, Rheumatoid - complications - immunology - physiopathology-
dc.subject.meshCoronary Artery Disease - epidemiology - immunology - physiopathology-
dc.subject.meshEndothelium, Vascular - immunology - pathology-
dc.subject.meshMesenchymal Stem Cells - immunology - pathology-
dc.titleRole of circulating endothelial progenitor cells in patients with rheumatoid arthritis with coronary calcificationen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0315-162X&volume=37&issue=3&spage=529&epage=535&date=2010&atitle=Role+of+circulating+endothelial+progenitor+cells+in+patients+with+rheumatoid+arthritis+with+coronary+calcificationen_HK
dc.identifier.emailYiu, KH: khkyiu@hku.hken_HK
dc.identifier.emailMok, MY: temy@hkucc.hku.hken_HK
dc.identifier.emailKhong, PL: plkhong@hkucc.hku.hken_HK
dc.identifier.emailLam, KF: hrntlkf@hkucc.hku.hken_HK
dc.identifier.emailLau, CS: cslau@hku.hken_HK
dc.identifier.emailTse, HF: hftse@hkucc.hku.hken_HK
dc.identifier.authorityYiu, KH=rp01490en_HK
dc.identifier.authorityMok, MY=rp00490en_HK
dc.identifier.authorityKhong, PL=rp00467en_HK
dc.identifier.authorityLam, KF=rp00718en_HK
dc.identifier.authorityLau, CS=rp01348en_HK
dc.identifier.authorityTse, HF=rp00428en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.3899/jrheum.090782en_HK
dc.identifier.pmid20080904-
dc.identifier.scopuseid_2-s2.0-77949685550en_HK
dc.identifier.hkuros169775en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-77949685550&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume37en_HK
dc.identifier.issue3en_HK
dc.identifier.spage529en_HK
dc.identifier.epage535en_HK
dc.identifier.isiWOS:000275135700010-
dc.publisher.placeCanadaen_HK
dc.identifier.scopusauthoridYiu, KH=35172267800en_HK
dc.identifier.scopusauthoridWang, S=24598284300en_HK
dc.identifier.scopusauthoridMok, MY=7006024184en_HK
dc.identifier.scopusauthoridOoi, GC=7006176119en_HK
dc.identifier.scopusauthoridKhong, PL=7006693233en_HK
dc.identifier.scopusauthoridLau, CP=35275317200en_HK
dc.identifier.scopusauthoridLai, WH=18434390500en_HK
dc.identifier.scopusauthoridWong, LY=36097267000en_HK
dc.identifier.scopusauthoridLam, KF=8948421200en_HK
dc.identifier.scopusauthoridLau, CS=14035682100en_HK
dc.identifier.scopusauthoridTse, HF=7006070805en_HK

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