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Article: Late measures of microstructural alterations in severe neonatal hypoxic-ischemic encephalopathy by MR diffusion tensor imaging

TitleLate measures of microstructural alterations in severe neonatal hypoxic-ischemic encephalopathy by MR diffusion tensor imaging
Authors
KeywordsAnimal models
Diffusion tensor imaging
Hypoxic-ischemic encephalopathy
Microstructural integrity
MRI
Neonates
White matter reorganization
Issue Date2009
PublisherPergamon. The Journal's web site is located at http://www.elsevier.com/locate/ijdevneu
Citation
International Journal Of Developmental Neuroscience, 2009, v. 27 n. 6, p. 607-615 How to Cite?
AbstractNeonatal hypoxic-ischemic encephalopathy is a major cause of brain damage in infants, and is associated with periventricular white matter injury and chronic neurological dysfunctions. However, the mechanisms of the chronic white matter injury and reorganization are still unclear. In this study, in vivo diffusion tensor imaging (DTI) was employed to evaluate the late changes of white matter microstructural integrity in the rat brains at 10 weeks after severe neonatal hypoxic-ischemic insults at postnatal day 7. In the fractional anisotropy directionality map, qualitative evaluation showed that a dorsoventrally oriented fiber bundle extended from the corpus callosum into the cyst in the anterior brain, whilst the posterior peri-infarct areas had similar fiber orientations as the contralateral internal capsule, optic tract and fimbria of hippocampus. Compared to the contralateral hemisphere, significantly higher fractional anisotropy, axial diffusivity and diffusion trace value were observed quantitatively in the distal end of the extended fiber bundle connecting the anterior and posterior white matters rostrocaudally. A significantly lower fractional anisotropy but higher axial and radial diffusivities and trace were also found in the ipsilateral corpus callosum, proximal external capsule and anterior commissure, while slightly lower fractional anisotropy and axial diffusivity were noticed in the ipsilateral internal capsule and optic nerve. It was suggested that increased fractional anisotropy, axial diffusivity and trace characterize white matter reorganization in chronic neonatal hypoxic-ischemic insults, whereas reduction in fractional anisotropy appears to characterize two types of white matter lesions, with significantly higher axial and radial diffusivities and trace being primary and slightly lower axial diffusivity being secondary. Combined with fractional anisotropy directionality map, in vivo DTI provides important indices to differentiate the chronic effects of severe neonatal hypoxic-ischemic injury and recovery globally, quantitatively and non-invasively. © 2009 ISDN.
Persistent Identifierhttp://hdl.handle.net/10722/72333
ISSN
2015 Impact Factor: 2.38
2015 SCImago Journal Rankings: 1.109
ISI Accession Number ID
Funding AgencyGrant Number
Hong Kong ResearchHKU 7793/08M
Funding Information:

The authors would like to thank Dr. Ke-xia Cai, Mr. Matthew M. Cheung and Ms Shu-juan Fan at the Laboratory of Biomedical Imaging and Signal Processing at The University of Hong Kong for their technical assistance. This work was supported by Hong Kong Research Grant Council (HKU 7793/08M).

References

 

DC FieldValueLanguage
dc.contributor.authorChan, KCen_HK
dc.contributor.authorKhong, Plen_HK
dc.contributor.authorLau, Hfen_HK
dc.contributor.authorCheung, Pten_HK
dc.contributor.authorWu, EXen_HK
dc.date.accessioned2010-09-06T06:40:37Z-
dc.date.available2010-09-06T06:40:37Z-
dc.date.issued2009en_HK
dc.identifier.citationInternational Journal Of Developmental Neuroscience, 2009, v. 27 n. 6, p. 607-615en_HK
dc.identifier.issn0736-5748en_HK
dc.identifier.urihttp://hdl.handle.net/10722/72333-
dc.description.abstractNeonatal hypoxic-ischemic encephalopathy is a major cause of brain damage in infants, and is associated with periventricular white matter injury and chronic neurological dysfunctions. However, the mechanisms of the chronic white matter injury and reorganization are still unclear. In this study, in vivo diffusion tensor imaging (DTI) was employed to evaluate the late changes of white matter microstructural integrity in the rat brains at 10 weeks after severe neonatal hypoxic-ischemic insults at postnatal day 7. In the fractional anisotropy directionality map, qualitative evaluation showed that a dorsoventrally oriented fiber bundle extended from the corpus callosum into the cyst in the anterior brain, whilst the posterior peri-infarct areas had similar fiber orientations as the contralateral internal capsule, optic tract and fimbria of hippocampus. Compared to the contralateral hemisphere, significantly higher fractional anisotropy, axial diffusivity and diffusion trace value were observed quantitatively in the distal end of the extended fiber bundle connecting the anterior and posterior white matters rostrocaudally. A significantly lower fractional anisotropy but higher axial and radial diffusivities and trace were also found in the ipsilateral corpus callosum, proximal external capsule and anterior commissure, while slightly lower fractional anisotropy and axial diffusivity were noticed in the ipsilateral internal capsule and optic nerve. It was suggested that increased fractional anisotropy, axial diffusivity and trace characterize white matter reorganization in chronic neonatal hypoxic-ischemic insults, whereas reduction in fractional anisotropy appears to characterize two types of white matter lesions, with significantly higher axial and radial diffusivities and trace being primary and slightly lower axial diffusivity being secondary. Combined with fractional anisotropy directionality map, in vivo DTI provides important indices to differentiate the chronic effects of severe neonatal hypoxic-ischemic injury and recovery globally, quantitatively and non-invasively. © 2009 ISDN.en_HK
dc.languageengen_HK
dc.publisherPergamon. The Journal's web site is located at http://www.elsevier.com/locate/ijdevneuen_HK
dc.relation.ispartofInternational Journal of Developmental Neuroscienceen_HK
dc.subjectAnimal modelsen_HK
dc.subjectDiffusion tensor imagingen_HK
dc.subjectHypoxic-ischemic encephalopathyen_HK
dc.subjectMicrostructural integrityen_HK
dc.subjectMRIen_HK
dc.subjectNeonatesen_HK
dc.subjectWhite matter reorganizationen_HK
dc.subject.meshAnimalsen_HK
dc.subject.meshAnimals, Newbornen_HK
dc.subject.meshAnisotropyen_HK
dc.subject.meshAxons - pathologyen_HK
dc.subject.meshBrain - growth & development - pathology - physiopathologyen_HK
dc.subject.meshBrain Mappingen_HK
dc.subject.meshCorpus Callosum - pathology - physiopathologyen_HK
dc.subject.meshDiffusionen_HK
dc.subject.meshDiffusion Magnetic Resonance Imaging - methodsen_HK
dc.subject.meshDisease Models, Animalen_HK
dc.subject.meshFemaleen_HK
dc.subject.meshHypoxia-Ischemia, Brain - pathology - physiopathologyen_HK
dc.subject.meshImage Processing, Computer-Assisted - methodsen_HK
dc.subject.meshInternal Capsule - pathologyen_HK
dc.subject.meshMaleen_HK
dc.subject.meshNerve Fibers, Myelinated - pathologyen_HK
dc.subject.meshOptic Nerve - pathologyen_HK
dc.subject.meshPredictive Value of Testsen_HK
dc.subject.meshRatsen_HK
dc.subject.meshRats, Sprague-Dawleyen_HK
dc.subject.meshSensitivity and Specificityen_HK
dc.subject.meshTime Factorsen_HK
dc.titleLate measures of microstructural alterations in severe neonatal hypoxic-ischemic encephalopathy by MR diffusion tensor imagingen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0736-5748&volume=27&spage=607&epage=615&date=2009&atitle=Late+measures+of+microstructural+alterations+in+severe+neonatal+hypoxic-ischemic+encephalopathy+by+MR+diffusion+tensor+imagingen_HK
dc.identifier.emailKhong, Pl:plkhong@hkucc.hku.hken_HK
dc.identifier.emailCheung, Pt:ptcheung@hkucc.hku.hken_HK
dc.identifier.emailWu, EX:ewu1@hkucc.hku.hken_HK
dc.identifier.authorityKhong, Pl=rp00467en_HK
dc.identifier.authorityCheung, Pt=rp00351en_HK
dc.identifier.authorityWu, EX=rp00193en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.ijdevneu.2009.05.012en_HK
dc.identifier.pmid19505567-
dc.identifier.scopuseid_2-s2.0-68549117012en_HK
dc.identifier.hkuros177120-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-68549117012&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume27en_HK
dc.identifier.issue6en_HK
dc.identifier.spage607en_HK
dc.identifier.epage615en_HK
dc.identifier.isiWOS:000269816300013-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridChan, KC=34968940300en_HK
dc.identifier.scopusauthoridKhong, Pl=7006693233en_HK
dc.identifier.scopusauthoridLau, Hf=23004851000en_HK
dc.identifier.scopusauthoridCheung, Pt=7202595465en_HK
dc.identifier.scopusauthoridWu, EX=7202128034en_HK
dc.identifier.citeulike5371889-

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