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Article: The evaluation of Wallerian degeneration in chronic paediatric middle cerebral artery infarction using diffusion tensor MR imaging

TitleThe evaluation of Wallerian degeneration in chronic paediatric middle cerebral artery infarction using diffusion tensor MR imaging
Authors
KeywordsDiffusion tensor magnetic resonance imaging
Neuromotor outcome
Paediatric infarction
Stroke
Wallerian degeneration
Issue Date2004
PublisherS Karger AG. The Journal's web site is located at http://www.karger.com/CED
Citation
Cerebrovascular Diseases, 2004, v. 18 n. 3, p. 240-247 How to Cite?
AbstractBackground: The long-term neuromotor outcome in paediatric strokes ranges from normal to varying degrees of hemiplegia. We evaluated the indices of diffusion tensor magnetic resonance imaging (DTI), fractional anisotropy and mean diffusivity to determine if these indices can identify and quantify the presence of Wallerian degeneration in paediatric patients with chronic middle cerebral artery infarction, and to determine if these quantitative parameters correlate with the neuromotor outcome. Methods: Eleven children (mean age 8.1 years) with evidence of unilateral middle cerebral artery stroke on magnetic resonance imaging and 10 control subjects (mean age 8.7 years) were studied. Neuromotor outcome was based on functions of the affected hand: mild (n = 3), moderate (n = 6), and severe (n = 2) hemiparesis. Fractional anisotropy and mean diffusivity of the ipsilateral corticospinal tract were compared with matched contralateral regions using the Mann-Whitney U test. Spearman's test was performed to study the relationship between neuromotor outcome and the following: ipsilateral-to-contralateral ratio of fractional anisotropy, mean diffusivity and cerebral peduncle area, and the largest infarction size. Results: For control subjects, there were no significant differences in fractional anisotropy and mean diffusivity of the corticospinal tract between the right and left side. For patients, fractional anisotropy decreased by 18% and mean diffusivity increased by 8% in the ipsilateral compared to the contralateral corticospinal tract. Neuromotor outcome correlated with the ipsilateral-to-contralateral ratio of fractional anisotropy (r = -0.638, p = 0.035) but not with the mean diffusivity ratio, cerebral peduncle area ratio and largest infarction size. Conclusion: DTI can be used to detect and quantify Wallerian degeneration in chronic paediatric middle cerebral artery infarction. Our preliminary data show that loss of anisotropy in the corticospinal tract correlates with neuromotor outcome. Copyright © 2004 S. Karger AG, Basel.
Persistent Identifierhttp://hdl.handle.net/10722/72328
ISSN
2015 Impact Factor: 3.359
2015 SCImago Journal Rankings: 1.744
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorKhong, PLen_HK
dc.contributor.authorZhou, LJen_HK
dc.contributor.authorOoi, GCen_HK
dc.contributor.authorChung, BHYen_HK
dc.contributor.authorCheung, RTFen_HK
dc.contributor.authorWong, VCNen_HK
dc.date.accessioned2010-09-06T06:40:34Z-
dc.date.available2010-09-06T06:40:34Z-
dc.date.issued2004en_HK
dc.identifier.citationCerebrovascular Diseases, 2004, v. 18 n. 3, p. 240-247en_HK
dc.identifier.issn1015-9770en_HK
dc.identifier.urihttp://hdl.handle.net/10722/72328-
dc.description.abstractBackground: The long-term neuromotor outcome in paediatric strokes ranges from normal to varying degrees of hemiplegia. We evaluated the indices of diffusion tensor magnetic resonance imaging (DTI), fractional anisotropy and mean diffusivity to determine if these indices can identify and quantify the presence of Wallerian degeneration in paediatric patients with chronic middle cerebral artery infarction, and to determine if these quantitative parameters correlate with the neuromotor outcome. Methods: Eleven children (mean age 8.1 years) with evidence of unilateral middle cerebral artery stroke on magnetic resonance imaging and 10 control subjects (mean age 8.7 years) were studied. Neuromotor outcome was based on functions of the affected hand: mild (n = 3), moderate (n = 6), and severe (n = 2) hemiparesis. Fractional anisotropy and mean diffusivity of the ipsilateral corticospinal tract were compared with matched contralateral regions using the Mann-Whitney U test. Spearman's test was performed to study the relationship between neuromotor outcome and the following: ipsilateral-to-contralateral ratio of fractional anisotropy, mean diffusivity and cerebral peduncle area, and the largest infarction size. Results: For control subjects, there were no significant differences in fractional anisotropy and mean diffusivity of the corticospinal tract between the right and left side. For patients, fractional anisotropy decreased by 18% and mean diffusivity increased by 8% in the ipsilateral compared to the contralateral corticospinal tract. Neuromotor outcome correlated with the ipsilateral-to-contralateral ratio of fractional anisotropy (r = -0.638, p = 0.035) but not with the mean diffusivity ratio, cerebral peduncle area ratio and largest infarction size. Conclusion: DTI can be used to detect and quantify Wallerian degeneration in chronic paediatric middle cerebral artery infarction. Our preliminary data show that loss of anisotropy in the corticospinal tract correlates with neuromotor outcome. Copyright © 2004 S. Karger AG, Basel.en_HK
dc.languageengen_HK
dc.publisherS Karger AG. The Journal's web site is located at http://www.karger.com/CEDen_HK
dc.relation.ispartofCerebrovascular Diseasesen_HK
dc.rightsCerebrovascular Diseases. Copyright © S Karger AG.en_HK
dc.subjectDiffusion tensor magnetic resonance imagingen_HK
dc.subjectNeuromotor outcomeen_HK
dc.subjectPaediatric infarctionen_HK
dc.subjectStrokeen_HK
dc.subjectWallerian degenerationen_HK
dc.subject.meshAdolescenten_HK
dc.subject.meshAnisotropyen_HK
dc.subject.meshCase-Control Studiesen_HK
dc.subject.meshChilden_HK
dc.subject.meshChild, Preschoolen_HK
dc.subject.meshDiffusion Magnetic Resonance Imagingen_HK
dc.subject.meshFemaleen_HK
dc.subject.meshHand - physiopathologyen_HK
dc.subject.meshHumansen_HK
dc.subject.meshInfanten_HK
dc.subject.meshInfarction, Middle Cerebral Artery - complications - diagnosis - physiopathologyen_HK
dc.subject.meshInternal Capsule - pathologyen_HK
dc.subject.meshMaleen_HK
dc.subject.meshMesencephalon - pathologyen_HK
dc.subject.meshMovementen_HK
dc.subject.meshNervous System - physiopathologyen_HK
dc.subject.meshParesis - etiology - physiopathologyen_HK
dc.subject.meshPyramidal Tracts - pathologyen_HK
dc.subject.meshWallerian Degeneration - diagnosis - etiologyen_HK
dc.titleThe evaluation of Wallerian degeneration in chronic paediatric middle cerebral artery infarction using diffusion tensor MR imagingen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1015-9770&volume=18&spage=240&epage=247&date=2004&atitle=The+Evaluation+of+Wallerian+Degeneration+in+Chronic+Paediatric+Middle+Cerebral+Artery+Infarction+Using+Diffusion+Tensor+MR+Imagingen_HK
dc.identifier.emailKhong, PL:plkhong@hkucc.hku.hken_HK
dc.identifier.emailChung, BHY:bhychung@hku.hken_HK
dc.identifier.emailCheung, RTF:rtcheung@hku.hken_HK
dc.identifier.emailWong, VCN:vcnwong@hku.hken_HK
dc.identifier.authorityKhong, PL=rp00467en_HK
dc.identifier.authorityChung, BHY=rp00473en_HK
dc.identifier.authorityCheung, RTF=rp00434en_HK
dc.identifier.authorityWong, VCN=rp00334en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1159/000079961en_HK
dc.identifier.pmid15273442-
dc.identifier.scopuseid_2-s2.0-4644261145en_HK
dc.identifier.hkuros95196en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-4644261145&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume18en_HK
dc.identifier.issue3en_HK
dc.identifier.spage240en_HK
dc.identifier.epage247en_HK
dc.identifier.isiWOS:000223897600011-
dc.publisher.placeSwitzerlanden_HK
dc.identifier.scopusauthoridKhong, PL=7006693233en_HK
dc.identifier.scopusauthoridZhou, LJ=7404125958en_HK
dc.identifier.scopusauthoridOoi, GC=7006176119en_HK
dc.identifier.scopusauthoridChung, BHY=7203043997en_HK
dc.identifier.scopusauthoridCheung, RTF=7202397498en_HK
dc.identifier.scopusauthoridWong, VCN=7202525632en_HK

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